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The Mode of Action of Vinca Alkaloids
Oncology, 2009P388 leukemia-bearing mice were given a single i.p. injection of [14C]-vincristine and the levels of radioactivity in the tumors and host tissues were determined as a function of time. The highest levels of radioactivity were found in the gallbladder followed by the tumor, spleen and liver, respectively.
O, Csuka +3 more
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Chemistry of Natural Compounds, 1977
1. From the epigeal part ofVinca major have been isolated the known bases akuammicine, vincamajine, vincamajoridine, and ervine, and the new alkaloid majorinine with the composition C22H24N2O4, mp 195–196°C.
L. I. Il'yashenko +3 more
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1. From the epigeal part ofVinca major have been isolated the known bases akuammicine, vincamajine, vincamajoridine, and ervine, and the new alkaloid majorinine with the composition C22H24N2O4, mp 195–196°C.
L. I. Il'yashenko +3 more
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2000
Abstract Vincristine (VCR) and vinblastine (VBL), derivatives of the periwinkle plant (Vinca rosea), are important chemotherapeutic agents with similar neurotoxic actions. VCR, the subject here, is far more widely used than VBL and has Iqbal Z, Ochs S (1980) Uptake of Vinca alkaloids into mammalian nerve and its subcellular components.
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Abstract Vincristine (VCR) and vinblastine (VBL), derivatives of the periwinkle plant (Vinca rosea), are important chemotherapeutic agents with similar neurotoxic actions. VCR, the subject here, is far more widely used than VBL and has Iqbal Z, Ochs S (1980) Uptake of Vinca alkaloids into mammalian nerve and its subcellular components.
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Vindesine: A New Vinca Alkaloid
1980Vindesine (VDS) is an analogue of the vinca alkaloids. Its spectrum of antitumoral activity is similar to that of vincristine (VCR), but with milder experimental neurotoxicity, and it inhibits the polymerization of tubulin. Its terminal half-life is 24 h and its plasma clearance is intermediate between those of vinblastine (VLB) and VCR.
M, Bayssas +9 more
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Vinca Alkaloids and Platelet Function
Annals of Internal Medicine, 1984Excerpt To the editor: The recent article by Ahn and associates (1) reported the use of slow infusions of vinca alkaloids in vivo to load autologous platelets for the treatment of idiopathic thromb...
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Indole Alkaloids from Vinca sardoa, a New Species of Vinca
HETEROCYCLES, 1990Four natural N-methylindolines have been isolated from the roots of Vinca sardoa (Stearn) Pignati. They are ent-N(1)-methyl-14,15-didehydroaspidospermidine (7),N(1)-methyl-14,15-didehydroaspidofractinine (10), N(1)-methylaspidofractinine (11) and N(1)-methyl-14,15-didehydrotuboxenine (13)
S. CRIPPA +5 more
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Synthesis and SAR of vinca alkaloid analogues
Bioorganic & Medicinal Chemistry Letters, 2009Versatile intermediates 12'-iodovinblastine, 12'-iodovincristine and 11'-iodovinorelbine were utilized as substrates for transition metal based chemistry which led to the preparation of novel analogues of the vinca alkaloids. The synthesis of key iodo intermediates, their transformation into final products, and the SAR based upon HeLa and MCF-7 cell ...
Matthew E, Voss +15 more
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Plant Alkaloids: The Vinca Alkaloids
1989Although a large number of compounds from a wide variety of plants have been tested for antitumor activity, none has played a more vital role in cancer chemotherapy than the vinca alkaloids. These compounds are present in minute quantities in the plant Catharanthus roseus G. Don (Vinca rosea Linn.), commonly called the periwinkle.
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