Vincristine-induced brain toxicity is reduced with prevention of peripheral axon degeneration in Sarm1 knockout mice [PDF]
Acta Neuropathologica CommunicationsVincristine is an essential chemotherapy agent administered for various pediatric cancers including acute lymphoblastic leukemia (ALL). While multi-agent chemotherapy for pediatric ALL is highly curative, with survival approaching 95%, it carries the ...
Jonas Yeung +10 more
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Vincristine Treatment Protects Against Podocyte Damage in Focal Segmental Glomerulosclerosis [PDF]
Kidney International ReportsIntroduction: Focal segmental glomerulosclerosis (FSGS) is associated with podocyte damage resulting in cytoskeletal alterations leading to foot process effacement. Vincristine is a chemoprotective drug which alters cytoskeletal microtubules and has been
William J. Mason +11 more
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Molecules, 2021 Vincristine is a clinically used antimicrotubule drug for treating patients with lymphoma. Due to its property of increasing platelet counts, vincristine is also used to treat patients with immune thrombocytopenia.
Li-Ming Lien +12 more
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Acta Pharmaceutica Sinica B, 2023 Vincristine, a widely used chemotherapeutic agent for treating different cancer, often induces severe peripheral neuropathic pain. A common symptom of vincristine-induced peripheral neuropathic pain is mechanical allodynia and hyperalgesia.
Mingli Duan +6 more
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An adolescent rat model of vincristine-induced peripheral neuropathy
Neurobiology of Pain, 2021 Childhood acute lymphoblastic leukemia (ALL) is a significant clinical problem that can be effectively treated with vincristine, a vinca alkaloid-based chemotherapeutic agent.
Ai-Ling Li +5 more
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Treatment outcomes of AIDS-associated Kaposi's sarcoma under a routine antiretroviral therapy program in Lilongwe, Malawi: bleomycin/vincristine compared to vincristine monotherapy. [PDF]
PLoS ONE, 2014 Despite Kaposi's sarcoma (KS) being the most prevalent AIDS-associated cancer in resource limited settings, optimal treatment options remain unknown.
Albert A Mwafongo +7 more
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Asian Pacific Journal of Tropical Biomedicine, 2022 Objective: To explore the mechanism of drug resistance in acute lymphoblastic leukemia and the anti-tumor effect of combination therapy of dehydroabietic acid and vincristine against acute lymphoblastic leukemia cells.
Li-Li Shen +3 more
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Development of the DNA-based voltammetric biosensor for detection of vincristine as anticancer drug
Frontiers in Chemistry, 2023 In the article presented herein, a deoxyribonucleic acid (DNA) biosensor is introduced for Vincristine determination in pharmaceutical preparations based on the modification of screen printed electrode (SPE) with double-stranded DNA (ds-DNA), polypyrrole
Mahmoud Abbasi +8 more
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Interleukin-4 protects from chemotherapy-induced peripheral neuropathy in mice modal via the stimulation of IL-4/STAT6 signaling [PDF]
Acta Cirúrgica Brasileira, 2018 Purpose: To investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. Methods: The mouse model of vincristine-induced peripheral neuropathy and interleukin (IL)-4 knockout mice were utilized to investigate ...
Qingbin Shi +5 more
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AUT-M enterosorbent stabilizes glutathione system in vincristine-treated rats with dimethylhydrazine-induced colon cancer [PDF]
The Ukrainian Biochemical Journal, 2023 Colorectal cancer is one of the leading causes of mortality in the world. The search for new methods of therapy for this disease that could correct the state of oxidative stress during the development of neoplasms is up to date.
O. I. Kachur +4 more
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