Vinyl-aza-[3]cumulene intermediates induced polymerization for accessing E-dienyl poly(sulfonylamidines) towards pH-responsive drug delivery [PDF]
Nature CommunicationsThe development of reactive intermediates is very significant to construct functional compounds and polymers for multicomponent reactions and multicomponent polymerizations. Heterocumulenes as unique intermediates could be used for the rapid construction
Xuejian Li +3 more
doaj +2 more sources
Vinyl Azides as Radical Acceptors in the Vitamin B12-Catalyzed Synthesis of Unsymmetrical Ketones
Organic Letters, 2021 Vinyl azides are very reactive species and as such are useful building blocks, in particular, in the synthesis of N-heterocycles. They can also serve as precursors of ketones. These form in reactions of vinyl azides with nucleophiles or radicals. We have
Dorota Gryko, Sabina Pisarek
exaly +2 more sources
Mild C─F Activation of Azido(per)Fluoroalkanes. [PDF]
ChemistryMild and selective activation of C(sp3)–F bonds in azido(per)fluoroalkanes using thiolates was developed, leading to novel functionalized azides. The reaction is initiated by nucleophilic attack of the sulfur atom to the terminal nitrogen of the azido group, followed by fluoride ion elimination.
Shaitanova O +7 more
europepmc +2 more sources
Catalyst-Free Synthesis of 2,4-Disubstituted‑1H‑imidazoles through [3 + 2] Cyclization of Vinyl Azides with Amidines [PDF]
ACS Omega, 2017 N. Naresh Kumar Reddy +3 more
doaj +2 more sources
Synthesis of α-Fluoroketones From Vinyl Azides and Mechanism Interrogation
Organic Letters, 2016 An efficient and mild fluorination of vinyl azides for the synthesis of α-fluoroketones is described. The mechanistic studies indicated that a single-electron transfer (SET) and a subsequent fluorine atom transfer process could be involved in the ...
Shu-Wei Wu (1447564), Feng Liu (72874)
exaly +2 more sources
ChemInform Abstract: Amide Synthesis by Nucleophilic Attack of Vinyl Azides.
Angewandte Chemie, 2014 A method for the synthesis of amide-containing molecules was developed using vinyl azides as an enamine-type nucleophile towards carbon electrophiles, such as imines, aldehydes, and carbocations that were generated from alcohols in the presence of BF3 ...
Shunsuke Chiba +9 more
core +4 more sources
Synthesis of Polysubstituted N-H Pyrroles from Vinyl Azides and 1,3-Dicarbonyl Compounds
, 2016 Two synthetic methods for tetra- and trisubstituted N-H pyrroles are presented: (i) the thermal pyrrole formation by the reaction of vinyl azides with 1,3-dicarbonyl compounds via the 1,2-addition of 1,3-dicarbonyl compounds to 2H-azirine intermediates ...
Guillaume Lapointe (2168788) +3 more
core +6 more sources
Click'n ROPISA: One-Pot Synthesis of Ultrabright Fluorescent Nanoparticles Made of Polypeptides. [PDF]
Angew Chem Int Ed EnglSelf‐assembly and fluorophore conjugation proceed rapidly in a one‐pot “Click'n ROPISA” process, yielding intensely fluorescent polypeptide nanoparticles with tunable visible emission. High dye loading enables efficient energy transfer and single‐particle visualization, while the straightforward synthesis provides versatile access to bright ...
Hammou AEJ +7 more
europepmc +3 more sources
Chinese Journal of Catalysis, 2019 A simple and efficient process involving the Rh(II)-catalyzed [1+1+3] annulation of diazooxindoles and vinyl azides has been developed for the synthesis of spiropyrrolidine oxindoles with potential biological activity and significant synthetic ...
Boshun Wan
exaly +2 more sources
Intramolecular Schmidt Reaction of Vinyl Azides with Cyclic Ketones
Organic Letters, 2018 Cyclic ketones tethered with a vinyl azide group undergo a Schmidt-hydrolysis sequence to give secondary lactams bearing a ketone side chain. Secondary lactams are obtained in a regioselective manner that is not possible in a conventional Schimdt ...
Peng Chen (6514) +6 more
core +3 more sources