Results 21 to 30 of about 11,831 (142)

Adult Female Sleep During Hypoxic Bed Rest

Frontiers in Neuroscience, 2022
PurposeHypobaric hypoxic habitats are currently being touted as a potential solution to minimise decompression procedures in preparation for extra vehicular activities during future space missions.
Jeroen Van Cutsem, Jeroen Van Cutsem, Nathalie Pattyn, Nathalie Pattyn, Olivier Mairesse, Olivier Mairesse, Bérénice Delwiche, Bérénice Delwiche, Helio Fernandez Tellez, Martine Van Puyvelde, Martine Van Puyvelde, Martine Van Puyvelde, Emilie Lacroix, Adam C. McDonnell, Ola Eiken, Igor B. Mekjavic, Igor B. Mekjavic   +16 more
doaj   +1 more source

Blood Lines: Intraspecific and Interspecific Variations in Anticoagulant Actions of Agkistrodon Viperid Venoms

Toxins
This study investigated the intraspecific and interspecific variability in the venom effects of Agkistrodon viperid snake species and subspecies (eleven venoms total) on plasma clotting times, fibrinogen levels, and fibrin clot strength.
Francisco C. P. Coimbra, Elda E. Sanchez, Bruno Lomonte, José María Gutiérrez, Juan J. Calvete, Bryan G. Fry   +5 more
doaj   +1 more source

Thrombotic microangiopathy following saw-scaled viper () envenoming in Sri Lanka

SAGE Open Medical Case Reports, 2021
The saw-scaled viper ( Echis carinatus ) is considered as a highly venomous snake in Sri Lanka. The clinical manifestations are localized pain and swelling, coagulopathy and renal impairment.
Selladurai Pirasath, Chandrakulasegeran Athirayan, Dilani Gajan   +2 more
doaj   +1 more source

Acute Exposure to European Viper Bite in Children: Advocating for a Pediatric Approach

Toxins, 2021
Viper bite is an uncommon but serious cause of envenoming in Europe, especially in children. Our study aim is to better describe and analyze the clinical course and treatment of viper bite envenoming in a pediatric population. We retrospectively reviewed
Marco Marano, Mara Pisani, Giorgio Zampini, Giuseppe Pontrelli, Marco Roversi   +4 more
doaj   +1 more source

Coagulopathy After Viper Snakebite in Vietnam and Relationship with Time of Admission

Journal of Multidisciplinary Healthcare, 2021
Xuan Thi Dang,1,2 Thanh Xuan Nguyen,3– 5 Thu Thi Hoai Nguyen,3,4 Hung Tran Ha1,2 1Vietnam Poison Control Center, Bach Mai Hospital, Hanoi, 100000, Vietnam; 2Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, 100000,
Dang XT, Xuan Nguyen T, Nguyen TTH, Ha HT   +3 more
doaj  

Understanding the Chemical Dynamics of "Viper": A Study in Calcium Homeostasis, Bone Integrity, and Mathematical Modelling in Gotham's Fictional Context [PDF]

EPJ Web of Conferences
The television series Gotham introduced a fictional green chemical called 'Viper,' a synthetic compound inducing superhuman strength at significant physiological cost.
Kumar Ashutosh, Kumar Prakash, Dixit Santosh, Kumar Niranjan, Alam Badshah   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Drug Discovery for Snakebite Envenoming: Wanderings Amid Historical Antidotes and Emerging Therapeutic Opportunities [PDF]

ChemMedChem
In this review, we provide an overview of selected historical antidotes against snakebite envenomation used in early modern Europe. Then, the evidence‐based antivenom activity of some natural compounds is discussed as resulting from more than two decades of research studies.
Bianconi E, Camaioni E, Oszajca P, Macchiarulo A.   +3 more
europepmc   +2 more sources

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Strophanthus sarmentosus Extracts and the Strophanthus Cardenolide Ouabain Inhibit Snake Venom Proteases from Echis ocellatus

Molecules
Strophanthus sarmentosus is recognised for various ethnomedicinal applications, including treatment after snakebites. However, only limited scientific evidence exists on its antivenomous capabilities.
Julius Abiola, Olapeju Aiyelaagbe, Akindele Adeyi, Babafemi Ajisebiola, Simone König   +4 more
doaj   +1 more source