Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms [PDF]
ToxinsSnakebite envenoming is a neglected tropical disease, responsible for approximately 140,000 deaths globally each year. Vipers and elapid snakes represent the most significant snake families in medical contexts, exhibiting a variety of venom components ...
Mahtab Khatibi +6 more
doaj +2 more sources
Effects of Cape Cobra (Naja nivea) Venom and Its Isolated Protein on the Modulation of Platelet Activation [PDF]
ToxinsThe Cape cobra (Naja nivea), one of Africa’s most lethal snakes, can cause rapid, life-threatening paralysis. However, the impact of this venom on platelet function and blood coagulation remains poorly understood. To address this gap, we investigated the
Mahtab Khatibi +5 more
doaj +2 more sources
The evolution of scale sensilla in the transition from land to sea in elapid snakes [PDF]
Open Biology, 2016 Scale sensilla are small tactile mechanosensory organs located on the head scales of many squamate reptiles (lizards and snakes). In sea snakes and sea kraits (Elapidae: Hydrophiinae), these scale organs are presumptive scale sensilla that purportedly ...
Edward Snelling +2 more
exaly +2 more sources
Toxins, 2016 Australia is the stronghold of the front-fanged venomous snake family Elapidae. The Australasian elapid snake radiation, which includes approximately 100 terrestrial species in Australia, as well as Melanesian species and all the world's true sea snakes,
Timothy Jackson +2 more
exaly +3 more sources
A Quest for a Universal Plasma-Derived Antivenom Against All Elapid Neurotoxic Snake Venoms
Frontiers in Immunology, 2021 This review describes the research aimed at the development of universal antivenom against elapid neurotoxic snake venoms. The antivenoms produced in Thailand in the 1980s were of low potency, especially against the elapid venoms.
Kavi Ratanabanangkoon
exaly +3 more sources
Venom Down Under: Dynamic Evolution of Australian Elapid Snake Toxins
Toxins, 2013 Despite the unparalleled diversity of venomous snakes in Australia, research has concentrated on a handful of medically significant species and even of these very few toxins have been fully sequenced.
Timothy Jackson +2 more
exaly +3 more sources
Profiling cytotoxicity of nanofractionated elapid snake venoms in human cell lines representing different tissues [PDF]
Journal of Pharmaceutical AnalysisElapid snakebites cause severe toxicity, predominantly neurotoxicity and general cytotoxicity. However, the specific cellular impacts of individual venom toxins remain largely underexplored.
Haifeng Xu +5 more
doaj +2 more sources
Distinct regulatory networks control toxin gene expression in elapid and viperid snakes [PDF]
BMC GenomicsBackground Venom systems are ideal models to study genetic regulatory mechanisms that underpin evolutionary novelty. Snake venom glands are thought to share a common origin, but there are major distinctions between venom toxins from the medically ...
Cassandra M. Modahl +8 more
doaj +2 more sources
Identification and Characterization of Novel Serpentoviruses in Viperid and Elapid Snakes [PDF]
VirusesViruses in the subfamily Serpentovirinae (order Nidovirales, family Tobaniviridae) can cause significant morbidity and mortality in captive snakes, but documented infections have been limited to snakes of the Boidae, Colubridae, Homalopsidae, and ...
Steven B. Tillis +11 more
doaj +2 more sources
From Venom to Vein: Factor VII Activation as a Major Pathophysiological Target for Procoagulant Australian Elapid Snake Venoms [PDF]
ToxinsAustralian elapid snake venoms are uniquely procoagulant, utilizing blood clotting enzyme Factor Xa (FXa) as a toxin, which evolved as a basal trait in this clade.
Uthpala Chandrasekara +5 more
doaj +2 more sources