From Venom to Vein: Factor VII Activation as a Major Pathophysiological Target for Procoagulant Australian Elapid Snake Venoms [PDF]
ToxinsAustralian elapid snake venoms are uniquely procoagulant, utilizing blood clotting enzyme Factor Xa (FXa) as a toxin, which evolved as a basal trait in this clade.
Uthpala Chandrasekara +5 more
doaj +4 more sources
Procoagulant Adaptation of a Blood Coagulation Prothrombinase-like Enzyme Complex in Australian Elapid Venom [PDF]
Toxins, 2010 The macromolecular enzyme complex prothrombinase serves an indispensable role in blood coagulation as it catalyzes the conversion of prothrombin to thrombin, a key regulatory enzyme in the formation of a blood clot.
Mettine H.A. Bos, Rodney M. Camire
doaj +4 more sources
The Unusual Metalloprotease-Rich Venom Proteome of the Australian Elapid Snake Hoplocephalus stephensii [PDF]
Toxins, 2022 The Australasian region is home to the most diverse elapid snake radiation on the planet (Hydrophiinae). Many of these snakes have evolved into unique ecomorphs compared to elapids on other continents; however, their venom compositions are poorly known ...
Theo Tasoulis +5 more
doaj +3 more sources
Elapid snake envenomation in horses: 52 cases (2006–2016) [PDF]
Equine Veterinary Journal, 2017 Summary Background Snake envenomation is a cause of morbidity and mortality in domestic animals worldwide. The clinical features of crotalid snake (pit viper) envenomation are widely reported and well described in horses but elapid snake envenomation is poorly characterised.
N. J. Bamford +6 more
openaire +7 more sources
Elapid Snake Venom Analyses Show the Specificity of the Peptide Composition at the Level of Genera Naja and Notechis [PDF]
Toxins, 2014 Elapid snake venom is a highly valuable, but till now mainly unexplored, source of pharmacologically important peptides. We analyzed the peptide fractions with molecular masses up to 10 kDa of two elapid snake venoms—that of the African cobra, N.
Aisha Munawar +10 more
doaj +2 more sources
A Simple and Novel Strategy for the Production of a Pan-specific Antiserum against Elapid Snakes of Asia. [PDF]
PLoS Neglected Tropical Diseases, 2016 Snakebite envenomation is a serious medical problem in many tropical developing countries and was considered by WHO as a neglected tropical disease.
Kavi Ratanabanangkoon +8 more
doaj +2 more sources
Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species [PDF]
Nature Communications, 2019 Antivenoms, obtained by venom immunization, have narrow species coverage due to low immunogenicity of venom neurotoxins. Here the authors immunize horses with a designed recombinant consensus neurotoxin, and the resulting antisera protect mice from ...
Guillermo de la Rosa +5 more
doaj +3 more sources
Hepatotoxic effect of elapid venom-a rare manifestation: Case report [PDF]
Journal of Family Medicine and Primary CareSnake bite is a neglected tropical disease affecting millions of people across the globe. The highest burden exists in South East Asia and Sub-Saharan Africa.
Partha K. Chaudhuri +6 more
doaj +2 more sources
Generalization of predator recognition: Velvet geckos display anti-predator behaviours in response to chemicals from non-dangerous elapid snakes [PDF]
Current Zoology, 2010 Many prey species detect chemical cues from predators and modify their behaviours in ways that reduce their risk of predation. Theory predicts that prey should modify their anti-predator responses according to the degree of threat posed by the predator ...
Jonathan K. WEBB, Weiguo DU, David PIKE, Richard SHINE
doaj +3 more sources
Evidence for Resistance to Coagulotoxic Effects of Australian Elapid Snake Venoms by Sympatric Prey (Blue Tongue Skinks) but Not by Predators (Monitor Lizards) [PDF]
Toxins, 2021 Some Australian elapids possess potently procoagulant coagulotoxic venoms which activate the zymogen prothrombin into the functional enzyme thrombin. Although the activity of Australian elapid prothrombin-activators has been heavily investigated with ...
Nicholas J. Youngman +2 more
doaj +2 more sources