Results 21 to 30 of about 2,149 (169)

Heterologous expression, protein folding and antibody recognition of a neurotoxin from the Mexican coral snake Micrurus laticorallis

Journal of Venomous Animals and Toxins including Tropical Diseases, 2016
Background The cysteine-rich neurotoxins from elapid venoms are primarily responsible for human and animal envenomation; however, their low concentration in the venom may hamper the production of efficient elapid antivenoms.
Herlinda Clement, Vianey Flores, Guillermo De la Rosa, Fernando Zamudio, Alejandro Alagon, Gerardo Corzo   +5 more
doaj   +1 more source

An immunoinformatic approach to assessing the immunogenic capacity of alpha-neurotoxins in elapid snake venoms

Frontiers in Pharmacology, 2023
Introduction: Most elapid snakes produce venoms that contain alpha-neurotoxins (α-NTXs), which are proteins that cause post-synaptic blockade and paralysis in snakebite envenoming.
Yi Wei Chan, Choo Hock Tan, Choon Han Heh, Kae Yi Tan   +3 more
doaj   +1 more source

Cytotoxin antibody-based colourimetric sensor for field-level differential detection of elapid among big four snake venom.

PLoS Neglected Tropical Diseases, 2021
Development of a rapid, on-site detection tool for snakebite is highly sought after, owing to its clinically and forensically relevant medicolegal significance.
Sherin Kaul, L Sai Keerthana, Pankaj Kumar, Komal Birader, Yathirajarao Tammineni, Deepali Rawat, Pankaj Suman   +6 more
doaj   +1 more source

Anticoagulant Activity of Naja nigricollis Venom Is Mediated by Phospholipase A2 Toxins and Inhibited by Varespladib

Toxins, 2021
Bites from elapid snakes typically result in neurotoxic symptoms in snakebite victims. Neurotoxins are, therefore, often the focus of research relating to understanding the pathogenesis of elapid bites.
Taline D. Kazandjian, Arif Arrahman, Kristina B. M. Still, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Mark C. Wilkinson, Jeroen Kool   +7 more
doaj   +1 more source

Action mechanism of snake venom l-amino acid oxidase and its double-edged sword effect on cancer treatment: Role of pannexin 1-mediated interleukin-6 expression

Redox Biology, 2023
Snake venom l-amino acid oxidases (svLAAOs) have been recognized as promising candidates for anticancer therapeutics. However, multiple aspects of their catalytic mechanism and the overall responses of cancer cells to these redox enzymes remain ambiguous.
Nam V. Truong, Trinh T.T. Phan, Tzu-Sheng Hsu, Phan Phu Duc, Lih-Yuan Lin, Wen-Guey Wu   +5 more
doaj   +1 more source

Pharmacokinetics of Snake Venom

Toxins, 2018
Understanding snake venom pharmacokinetics is essential for developing risk assessment strategies and determining the optimal dose and timing of antivenom required to bind all venom in snakebite patients. This review aims to explore the current knowledge
Suchaya Sanhajariya, Stephen B. Duffull, Geoffrey K. Isbister   +2 more
doaj   +1 more source

Cerebral Complications of Snakebite Envenoming: Case Studies

Toxins, 2022
There are an estimated 5.4 million snakebite cases every year. People with snakebite envenoming suffer from severe complications, or even death. Although some review articles cover several topics of snakebite envenoming, a review of the cases regarding ...
Yu-Kai Huang, Yen-Chia Chen, Chia-Chun Liu, Hui-Chun Cheng, Anthony T. Tu, Kun-Che Chang   +5 more
doaj   +1 more source

Rapid Progressive Course of Naja Naja Oxiana-bitten Patient [PDF]

Journal of Kerman University of Medical Sciences, 2022
Cases of snakebites especially with an elapidae are considered as a medical emergency. However, in some cases of elapidae envenomation, bite signs might be unpredictable.Case: Dorsal surface of the second finger of a 39-year-old man was bitten by N. Naja
Maliheh Rajabi, Bita Dadpour, Parastoo Rahimi, Mohammad Moshiri   +3 more
doaj   +1 more source

Diversification rates and phenotypic evolution in venomous snakes (Elapidae) [PDF]

Royal Society Open Science, 2016
The relationship between rates of diversification and of body size change (a common proxy for phenotypic evolution) was investigated across Elapidae, the largest radiation of highly venomous snakes.
Michael S. Y. Lee, Kate L. Sanders, Benedict King, Alessandro Palci   +3 more
doaj   +1 more source

Non-Native (Exotic) Snake Envenomations in the U.S., 2005–2011

Toxins, 2014
Non-native (exotic) snakes are a problematic source of envenomation worldwide. This manuscript describes the current demographics, outcomes and challenges of non-native snakebites in the United States (U.S.).
Brandon J. Warrick, Leslie V. Boyer, Steven A. Seifert   +2 more
doaj   +1 more source