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Viral infections induce multiple perturbations that spread along the links of the biological networks of the host cells. Understanding the impact of these cascading perturbations requires an exhaustive knowledge of the cellular machinery as well as a systems biology approach that reveals how individual components of the cellular system function ...
Barabasi, Albert-Laszlo+3 more
core +4 more sources
This special issue of PPAR Research contains an exciting array of valuable reviews examining the relationship between PPARs and various viral infections, varying from HIV to HCV and HBV. This assembly of reviews includes a group of three complimentary reviews addressing different facets of the cross-talk between HIV infection and antiretroviral ...
Mostafa Z. Badr+2 more
openaire +3 more sources
High Heritability Is Compatible with the Broad Distribution of Set Point Viral Load in HIV Carriers. [PDF]
Set point viral load in HIV patients ranges over several orders of magnitude and is a key determinant of disease progression in HIV. A number of recent studies have reported high heritability of set point viral load implying that viral genetic factors ...
Bonhoeffer, S, Fraser, C, Leventhal, GE
core +7 more sources
Viral-induced neurodegenerative disease. [PDF]
Viral etiology has been postulated in a variety of neurological diseases in humans, including multiple sclerosis. Several experimental animal models of viral-induced neurodegenerative disease provide insight into potential host- and pathogen-dependent ...
Buchmeier, MJ, Lane, TE
core +1 more source
Vaccination reduces the viral load and the risk of transmission of Jembrana disease virus in Bali cattle [PDF]
The efficacy of a tissue-derived vaccine, which is currently used in Indonesia to control the spread of Jembrana disease in Bali cattle, was determined by quantifying the viral load in plasma following experimental infection with Jembrana disease virus ...
Desport, M.+5 more
core +2 more sources
As part of the international outreach of the American Society of Hematology, this review addresses some aspects of the genetics, biology, epidemiology, and clinical relevance of viruses that cause a variety of hematopoietic disorders in human populations.
Genoveffa Franchini+2 more
openaire +3 more sources
Viral skin infections are some of the most common skin diseases in medical dermatology [...]
openaire +3 more sources
Should patients with abnormal liver function tests in primary care be tested for chronic viral hepatitis: cost minimisation analysis based on a comprehensively tested cohort [PDF]
Background Liver function tests (LFTs) are ordered in large numbers in primary care, and the Birmingham and Lambeth Liver Evaluation Testing Strategies (BALLETS) study was set up to assess their usefulness in patients with no pre-existing or self ...
AA Butt+52 more
core +3 more sources
Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis. [PDF]
The role of the CXC chemokine ligand 9 (CXCL9) in host defense following infection with mouse hepatitis virus (MHV) was determined. Inoculation of the central nervous system (CNS) of CXCL9-/- mice with MHV resulted in accelerated and increased mortality ...
Carr, Daniel JJ+4 more
core +1 more source
We live in an era of rapidly changing global landscapes and local environments. Viruses with RNA as their genetic material can quickly adapt to and exploit these varying conditions because of the high error rates of the virus enzymes (polymerases) that replicate their genomes.
Stuart T. Nichol+2 more
openaire +3 more sources