Results 71 to 80 of about 10,523,720 (359)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Detection of SFTS virus RNA and antibodies in severe fever with thrombocytopenia syndrome surveillance cases in endemic areas of China

BMC Infectious Diseases, 2019
Background Severe fever with thrombocytopenia syndrome (SFTS) is a newly identified severe infectious disease caused by SFTS phlebovirus (SFTSV). SFTS monitoring has been carried out since 2010 in mainland China.
Xiaoxia Huang, Shujun Ding, Xiaolin Jiang, Bo Pang, Quanfu Zhang, Chuan Li, Aqian Li, Jiandong Li, Mifang Liang, Shiwen Wang, Dexin Li   +10 more
doaj   +1 more source

Viral Diseases

, 1994
This chapter focuses on the naturally occurring viral diseases of rabbits. Poxviruses cause several important diseases in domestic and wild mammals and birds. Infection with poxviruses usually results in relatively mild disease involving the skin of the infected animals, however, generalized and often fatal disease may also occur, for example, in ...
DiGiacomo, Ronald F., John Maré, C.
openaire   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Human adenovirus among hospitalized children with respiratory tract infections in Beijing, China, 2017–2018

Virology Journal, 2019
Background Human adenoviruses (HAdVs) cause a wide range of diseases. However, the genotype diversity and epidemiological information relating to HAdVs among hospitalized children with respiratory tract infections (RTIs) is limited. Here, we describe the
Li-hong Yao, Chao Wang, Tian-li Wei, Hao Wang, Fen-lian Ma, Li-shu Zheng   +5 more
doaj   +1 more source

Viral diseases of ferrets

Veterinary Clinics of North America: Exotic Animal Practice, 2005
Distemper and rabies vaccination are highly recommended because of the almost invariable fatal outcome of these conditions. Vaccination should constitute an important part of a ferret's preventative medicine program. With the current and anticipated development and licensing of new vaccines, practitioners are invited to gain awareness of the latest ...
openaire   +3 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

A Mixture of T-Cell Epitope Peptides Derived from Human Respiratory Syncytial Virus F Protein Conferred Protection in DR1-TCR Tg Mice

Vaccines
Human respiratory syncytial virus (HRSV) poses a significant disease burden on global health. To date, two vaccines that primarily induce humoral immunity to prevent HRSV infection have been approved, whereas vaccines that primarily induce T-cell ...
Hong Guo, Yang Song, Hai Li, Hongqiao Hu, Yuqing Shi, Jie Jiang, Jinyuan Guo, Lei Cao, Naiying Mao, Yan Zhang   +9 more
doaj   +1 more source

Viral dynamics and immune correlates of COVID-19 disease severity

Clinical Infectious Diseases, 2020
Background Key knowledge gaps remain in the understanding of viral dynamics and immune response of SARS-CoV-2 infection. Methods We evaluated these characteristics and established their association with clinical severity in a prospective observational ...
B. Young, S. Ong, L. Ng, D. Anderson, W. Chia, P. Chia, L. Ang, T. Mak, S. Kalimuddin, L. Chai, S. Pada, S. Tan, L. Sun, Purnima Parthasarathy, Siew‐Wai Fong, Y. Chan, C. Tan, Bernett Lee, O. Rötzschke, Ying Ding, P. Tambyah, J. Low, L. Cui, T. Barkham, R. Lin, Y. Leo, L. Rénia, Lin‐Fa Wang, D. Lye, P. Lim, Brenda Sze Peng Ang, C. Lee, Lawrence Soon U Lee, L. Ling, O. Ng, M. Chan, K. Marimuthu, S. Vasoo, C. S. Wong, Tau-Hong Lee, S. Sadarangani, R. Lin, M. Sadasiv, Deborah Hee Ling Ng, Chiaw Yee Choy, Glorijoy Shi En Tan, Yuexia Tan, Stephanie Sutjipto, Pei Hua Lee, Jun-Yang Tay, T. Yeo, B. Khoo, W. C. Tay, Gabrielle Ng, Yun Yuan Mah, W. Tan, P. De, R. Pooja, J. Chia, Yuan Yi Constance Chen, S. Mendis, Boon Kiat Toh, Raymond Kok Choon Fong, Helen May Lin Oh, Jaime Mei Fong Chien, Humaira Shafi, Hau Yiang Cheong, T. Tan, T. Tan, B. Tan, L. Wijaya, I. Venkatachalam, Y. Chua, Benjamin Pei Zhi Cherng, Yvonne Fu Zi Chan, Hei Man Wong, S. Thien, Kenneth Choon Meng Goh, Shireen Yan Ling Tan, Lynette Lin Ean Oon, K. Chan, Li Lin, Douglas Su Gin Chan, S. Ooi, D. R. Narayana, J. Somani, Jolene Ee Ling Oon, Gabriel Yan, D. Allen, R. Jureen, B. Yan, Randy Foo, Adrian E. Z. Kang, Velraj Sivalingam, Wilson How, Norman Leo Fernandez, N. Yeo, R. Chee, S. N. Amrun   +98 more
semanticscholar   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source