Results 271 to 280 of about 2,672,670 (309)

Structural and functional diversity of viral IRESes

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2009
Some 20 years ago, the study of picornaviral RNA translation led to the characterization of an alternative mechanism of initiation by direct ribosome binding to the 5' UTR. By using a bicistronic vector, it was shown that the 5' UTR of the poliovirus (PV) or the Encephalomyelitis virus (EMCV) had the ability to bind the 43S preinitiation complex in a 5'
Laurent, Balvay, Ricardo, Soto Rifo, Emiliano P, Ricci, Didier, Decimo, Théophile, Ohlmann   +4 more
openaire   +2 more sources

Viral glycoprotein heterogeneity-enhancement of functional diversity

Glycoconjugate Journal, 1992
Variations in the amino acid sequence of RNA virus envelope glycoproteins can cause changes in their antigenicity and can alter the host-cell tropism of the virus and the degree of virulence which it exhibits. Such changes may alter the course and outcome of viral diseases, either directly because of changes in the biological properties of the ...
I T, Schulze, I D, Manger
openaire   +2 more sources

Diversity Analysis in Viral Metagenomes

2018
Viruses are the most abundant and diverse biological entity in the earth. Nowadays, there are several viral metagenomes from different ecological niches which have been used to characterize new viral particles and to determine their diversity. However, viral metagenomic data have the disadvantage to be high-dimensional compositional and sparse.
openaire   +2 more sources

RNA viromes from terrestrial sites across China expand environmental viral diversity

Nature Microbiology, 2022
Yan-Mei Chen, Sabrina Sadiq, Jun-hua Tian, Xiao Chen, Xian-dan Lin, Jin-jin Shen, Hao Chen, Z. Hao, M. Wille, Zhuocheng Zhou, Jun Wu, Feng Li, Hong-Wei Wang, Wei-Di Yang, Qi-Yi Xu, Wen Wang, Wen-Hua Gao, E. Holmes, Yong‐Zhen Zhang   +18 more
semanticscholar   +1 more source

Viral diversity and dynamics in an infant gut

Research in Microbiology, 2008
Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula,
Breitbart, Mya, Haynes, Matthew, Kelley, Scott, Angly, Florent, Edwards, Robert, Felts, Ben, Mahaffy, Joseph, Mueller, Jennifer, Nulton, James, Rayhawk, Steve, Rodriguez-Brito, Beltran, Salamon, Peter, Rohwer, Forest   +12 more
openaire   +3 more sources

Diverse viral cas genes antagonize CRISPR immunity

Nature
Prokaryotic CRISPR-Cas immunity is subverted by anti-CRISPRs (Acrs), which inhibit Cas protein activities when expressed during the phage lytic cycle or from resident prophages or plasmids1. Acrs often bind to specific cognate Cas proteins, and hence inhibition is typically limited to a single CRISPR-Cas subtype2.
Mark A. Katz, Edith M. Sawyer, Luke Oriolt, Albina Kozlova, Madison C. Williams, Shally R. Margolis, Matthew Johnson, Joseph Bondy-Denomy, Alexander J. Meeske   +8 more
openaire   +2 more sources

The Role of Viral Diversity in HIV Pathogenesis

Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology, 1995
From the time of seroconversion, patients who retain a high viral load are known to progress more rapidly to AIDS than individuals who have lower levels of HIV. Increased viral load is accompanied by decreasing CD4 cell numbers, and CD4 cell counts are therefore widely used as a diagnostic marker or predictor of progression in HIV patients.
openaire   +3 more sources

Viral Diversity, Evolution, and Selective Pressure

2019
The mechanisms of norovirus evolution are complex owing to the diversity among and within norovirus genogroups and genotypes. Evolutionary and epidemiological patterns vary among norovirus groups. Evolution in GII.4 noroviruses is more well-characterized than any other group, and several potential mechanisms of evolution have been described including ...
Angelique Ealy, Kari Debbink
openaire   +1 more source

Vaccines and viral antigenic diversity.

Revue scientifique et technique (International Office of Epizootics), 2007
Antigenic diversity among ribonucleic acid (RNA) viruses occurs as a result of rapid mutation during replication and recombination/reassortment between genetic material of related strains during co-infections. Variants which have a selective advantage in terms of ability to spread or to avoid host immunity become established within populations ...
openaire   +1 more source

Monkeypox virus emergence in wild chimpanzees reveals distinct clinical outcomes and viral diversity

Nature Microbiology, 2020
L. Patrono, Kamilla Pléh, Liran Samuni, M. Ulrich, Caroline Röthemeier, A. Sachse, Silvia Muschter, A. Nitsche, E. Couacy‐Hymann, C. Boesch, R. Wittig, S. Calvignac‐Spencer, F. Leendertz   +12 more
semanticscholar   +1 more source