Results 61 to 70 of about 2,672,670 (309)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Diversity of viral photosystem-I psaA genes [PDF]

The ISME Journal, 2014
Abstract Marine photosynthesis is one of the major contributors to the global carbon cycle and the world’s oxygen supply. This process is largely driven by cyanobacteria, namely Synechococcus and Prochlorococcus. Genes encoding photosystem-II (PSII) reaction center proteins are found in many cyanophage genomes, and are expressed during ...
Gur Hevroni, Hagay Enav, Forest Rohwer, Oded Béjà   +3 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Exploring viral diversity in fermented vegetables through viral metagenomics

Food Microbiology
Fermented vegetables are traditionally produced using the endogenous microorganisms present in raw ingredients. While the diversity of bacteria and fungi in fermented vegetables has been relatively well studied, phage communities remain largely unexplored.
Cantuti Gendre, Julia, Le Marrec, Claire, Chaillou, Stéphane, Omhover-Fougy, Lysiane, Landaud, Sophie, Dugat-Bony, Eric   +5 more
openaire   +3 more sources

Previously unknown evolutionary groups dominate the ssDNA gokushoviruses in oxic and anoxic waters of a coastal marine environment

Frontiers in Microbiology, 2015
Metagenomic studies have revealed that ssDNA phages from the family Microviridae subfamily Gokushovirinae are widespread in aquatic ecosystems. It is hypothesized that gokushoviruses occupy specialized niches, resulting in differences among genotypes ...
Jessica M. Labonté, Steven eHallam, Curtis A. Suttle   +2 more
doaj   +1 more source

Viral Metagenomic Analysis of the Fecal Samples in Domestic Dogs (Canis lupus familiaris)

Viruses, 2023
Canine diarrhea is a common intestinal illness that is usually caused by viruses, bacteria, and parasites, and canine diarrhea may induce morbidity and mortality of domestic dogs if treated improperly.
Hongyan Wang, Zongjie Li, Chuanfeng Li, Yanfeng Ma, Qing Sun, Hailong Zhang, Guangbin Niu, Jianchao Wei, Huochun Yao, Zhiyong Ma   +9 more
doaj   +1 more source

Demographic and environmental drivers of metagenomic viral diversity in vampire bats

Molecular Ecology, 2019
Viruses infect all forms of life and play critical roles as agents of disease, drivers of biochemical cycles and sources of genetic diversity for their hosts.
L. Bergner, R. Orton, J. Benavides, Daniel J. Becker, Carlos Tello, R. Biek, D. Streicker   +6 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A marine viral halogenase that iodinates diverse substrates [PDF]

Nature Chemistry, 2019
Oceanic cyanobacteria are the most abundant oxygen-generating phototrophs on our planet and are therefore important to life. These organisms are infected by viruses called cyanophages, which have recently shown to encode metabolic genes that modulate host photosynthesis, phosphorus cycling and nucleotide metabolism.
Gkotsi, Danai S, Ludewig, Hannes, Sharma, Sunil V, Connolly, Jack A, Dhaliwal, Jagwinder, Wang, Yunpeng, Unsworth, William P, Taylor, Richard J K, McLachlan, Matthew M W, Shanahan, Stephen, Naismith, James H, Goss, Rebecca J M   +11 more
openaire   +6 more sources

Fecal Viral Diversity of Captive and Wild Tasmanian Devils Characterized Using Virion-Enriched Metagenomics and Metatranscriptomics

Journal of Virology, 2019
The Tasmanian devil is an iconic Australian marsupial that has suffered an 80% population decline due to a contagious cancer, devil facial tumor disease, along with other threats.
Rowena Chong, M. Shi, C. Grueber, E. Holmes, C. Hogg, K. Belov, V. Barrs   +6 more
semanticscholar   +1 more source