Results 81 to 90 of about 2,929,622 (336)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Viruses, 2020 Human noroviruses (NoV) cause epidemics of acute gastroenteritis (AGE) worldwide and can be transmitted through consumption of contaminated foods. Fresh products such as shellfish can be contaminated by human sewage during production, which results in ...
Marion Desdouits +4 more
doaj +1 more source
Demographic and environmental drivers of metagenomic viral diversity in vampire bats
Molecular Ecology, 2019 Viruses infect all forms of life and play critical roles as agents of disease, drivers of biochemical cycles and sources of genetic diversity for their hosts.
L. Bergner +6 more
semanticscholar +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Molecular and biological diversity of HIV-1 in Brazil
Memorias do Instituto Oswaldo Cruz, 1992 To determine the genomic polymorphism and biological properties present in HIV-1 Brazilian isolates, were analyzed five viral isolates obtained from patients residing in Rio de Janeiro (P1 and P5), São Paulo (P3) and Bahia (P2 and P4) states.
José Carlos Couto-Fernandez +3 more
doaj +1 more source
Pathology and viral metagenomics, a recent history [PDF]
, 2013 Human, animal and plant viral pathologies have greatly benefited from recent metagenomics development. Viral metagenomics is a culture-independent approach used to investigate the complete viral genetic populations of a sample.
Albina, Emmanuel +5 more
core
Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses. [PDF]
, 2017 RNA viruses, such as poliovirus, have a great evolutionary capacity, allowing them to quickly adapt and overcome challenges encountered during infection.
Andino, Raul +6 more
core +3 more sources
Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans. [PDF]
, 2020 Here we studied HLA blocks and haplotypes in a group of 218 Lacandon Maya Native American using a high-resolution next generation sequencing (NGS) method.
Aguilar-Vázquez, José Artemio +23 more
core +1 more source
Journal of Virology, 2019 The Tasmanian devil is an iconic Australian marsupial that has suffered an 80% population decline due to a contagious cancer, devil facial tumor disease, along with other threats.
Rowena Chong +6 more
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source