Results 101 to 110 of about 2,929,622 (336)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Ecogenomics and Adaptation Strategies of Southern Ocean Viral Communities

mSystems, 2021
The Southern Ocean (SO) represents up to one-fifth of the total carbon drawdown worldwide. Intense selective pressures (low temperature, high UV radiation, and strong seasonality) and physical isolation characterize the SO, serving as a “natural ...
Tomás Alarcón-Schumacher, Sergio Guajardo-Leiva, Manuel Martinez-Garcia, Beatriz Díez   +3 more
doaj   +1 more source

Evolution of foot-and-mouth disease virus intra-sample sequence diversity during serial transmission in bovine hosts [PDF]

, 2013
RNA virus populations within samples are highly heterogeneous, containing a large number of minority sequence variants which can potentially be transmitted to other susceptible hosts. Consequently, consensus genome sequences provide an incomplete picture
Haydon, D.T., Juleff, N., King, D.P., Knowles, N.J., Morelli, M.J., Paton, D.J., Wright, C.F.   +6 more
core   +2 more sources

Viral Diversity of Tick Species Parasitizing Cattle and Dogs in Trinidad and Tobago

Scientific Reports, 2019
Ticks are vectors of a wide variety of pathogens that are implicated in mild to severe disease in humans and other animals. Nonetheless, the full range of tick-borne pathogens is unknown.
S. Sameroff, S. Sameroff, R. Tokarz, Roxanne A. Charles, K. Jain, A. Oleynik, X. Che, K. Georges, C. Carrington, W. Lipkin, C. Oura   +10 more
semanticscholar   +1 more source

Global diversity and biogeography of DNA viral communities in activated sludge systems

Microbiome, 2023
Background Activated sludge (AS) systems in wastewater treatment plants (WWTPs) harbor enormous viruses that regulate microbial metabolism and nutrient cycling, significantly influencing the stability of AS systems.
Xiangyu Fan, Mengzhi Ji, Dashuai Mu, Xianghe Zeng, Zhen Tian, Kaili Sun, Rongfeng Gao, Yang Liu, Xinyuan He, Linwei Wu, Qiang Li   +10 more
semanticscholar   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Virome of Terrestrial Mammals and Bats from Southern Brazil: Circulation of New Putative Members of the Togaviridae Family and Other Findings

Pathogens
The surveillance of wildlife viromes is essential for identifying zoonotic threats within the One Health framework. This study analyzed rectal and oral swabs from 88 individuals representing 13 species as felids, wild rodents, marsupials and non-human ...
Julyana Sthéfanie Simões Matos, Meriane Demoliner, Juliana Schons Gularte, Micheli Filippi, Vyctoria Malayhka de Abreu Góes Pereira, Mariana Soares da Silva, Matheus Nunes Weber, Marcelo Pereira de Barros, Fernando Rosado Spilki   +8 more
doaj   +1 more source

Epidemiology of Yam Viruses in Guadeloupe: Role of Cropping Practices and Seed-Tuber Supply

Viruses, 2022
The epidemiology of yam viruses remains largely unexplored. We present a large-scale epidemiological study of yam viruses in Guadeloupe based on the analysis of 1124 leaf samples collected from yams and weeds.
Mame Boucar Diouf, Sébastien Guyader, Olyvia Gaspard, Eric Francius, Pierre-Yves Teycheney, Marie Umber   +5 more
doaj   +1 more source

Selective escape from CD8+ T-Cell responses represents a major driving force of Human Immunodeficiency Virus Type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution [PDF]

, 2005
The sequence diversity of human immunodeficiency virus type 1 (HIV-1) represents a major obstacle to the development of an effective vaccine, yet the forces impacting the evolution of this pathogen remain unclear.
Allen, T.M., Altfeld, M., Geer, S.C., Kalife, E.T., Moore, C., O'Sullivan, K.M., DeSouza, I., Feeney, M.E., Eldridge, R.L., Maier, E.L., Kaufmann, D.E., Lahaie, M.P., Reyor, L., Tanzi, G., Johnston, M.N., Brander, C., Draenert, R., Rockstroh, J.K., Jessen, H., Rosenberg, E.S., Mallal, S.A., Walker, B.D.   +21 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source