Results 121 to 130 of about 225,726 (214)

Encoded Cell‐Material Interactions to Reroute Cytokine Signaling for Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
We present native MATRIX (Material Activated To Regulate Inducible gene eXpression), a co‐engineered material‐cell platform. Surfaces functionalized with antibodies for endogenous soluble ligands (e.g., IL‐1β or IL‐6) capture and immobilize ligands for presentation to a cognate, engineered synthetic Notch receptor, releasing a transcription factor (TF)
Zachary M. Eidman, Jhanvi Sharma, Joanne C. Lee, Nicholas F. Schulze, Hannah J. Brien, Kevin C. Corn, Marjan Rafat, Jonathan M. Brunger   +7 more
wiley   +1 more source

Healthy pangolin virome reveals mammalian viral diversity and zoonotic risk. [PDF]

Microbiome
Dong T, Wang Q, Que T, Si H, Su J, Chen Y, Yang K, Li C, Qin M, Li B, Zhu Y, Li S, Li Y, He M, Zhong Y, Xiao Q, Hu B, Zeng L.   +17 more
europepmc   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Metaviromic analysis of Ixodes ticks in Northwestern Russia reveals high viral diversity and novel RNA virus lineages. [PDF]

Sci Rep
Gladkikh AS, Naydenov DD, Sharova AA, Popova MR, Arbuzova TV, Klyuchnikova EO, Sbarzaglia VA, Gibitova EA, Forghani M, Tokarevich NK, Lunina GA, Ramsay ES, Dedkov VG.   +12 more
europepmc   +1 more source

Inhibition of VEGF‐Induced Angiogenesis and Vascular Leakage by Bicistronic Co‐Expression of Aflibercept and COMP‐Ang1

Advanced Healthcare Materials, EarlyView.
A bicistronic rAAV8 vector encoding Aflibercept (Afb) and COMP‐cAng1 simultaneously coordinates VEGF clearance and Tie2‐mediated vessel maturation. In a 3D angiogenesis‐on‐a‐chip model, rAAV8‐Afb/cAng1 effectively reverses pathological barrier breakdown under clinical disease‐mimicking challenges.
Bong‐Kyu Kim, Jaehong Min, Sang‐Hee Park, Subeen Shin, Sangbin Yu, Jeong‐Eun Park, Sujin Kim, Wooju Park, Jihoon Ko, Sunjong Kwon   +9 more
wiley   +1 more source

Metagenomic profiling unveils the viral diversity in field-collected Aedes larvae from Central India employing nanopore sequencing. [PDF]

Sci Rep
Gupta E, Sharma S, Dash PK, Parida M.
europepmc   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Viral diversity influences T-cell responses to enteric human adenoviruses F40 and F41. [PDF]

Virus Evol
Craven HM, Hoang JP, Mukhopadhyay R, Lambisia AW, Krishna BAC, Ravenhill BJ, Agoti CN, Houldcroft CJ.   +7 more
europepmc   +2 more sources

SARS-CoV-2 intra-host viral diversity associated with host innate and vaccine-induced immunity in an obese mouse model. [PDF]

BMC Infect Dis
Song W, Chen Y, Tong Y, Liu F, Li C, Ye Z, Ren P, Wang J, Cui X, Lam AH, Chu H, Li J, Chan JF, Yuen KY, Ou Z, Zhang AJ.   +15 more
europepmc   +1 more source

Self‐Assembled Inorganic Nanomembrane Tubes: Rolled‐Up Piezoelectrics for Microacoustic Wave‐Based Actuators and Sensors

Advanced Materials, EarlyView.
This study demonstrates a self‐assembly process to generate free‐standing piezoelectric nanomembranes, forming ultracompact microtubular acoustic wave sensors and actuators. The miniaturized 3D piezoelectric platform reported in this work can be applied in telecommunication, energy harvesting, and acoustofluidics. Moreover, the 3D self‐assembly can add
Raphaël C. L‐M. Doineau, Christian N. Saggau, Stefan Baunack, Thomas Gemming, Yara Abdelaal, Robert Weser, Oliver G. Schmidt, Hagen Schmidt, Andreas Winkler, Mariana Medina‐Sánchez   +9 more
wiley   +1 more source