Results 61 to 70 of about 240,853 (262)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Evolutionary Diversity of Bat Rabies Virus in São Paulo State, Brazil

Viruses
The history of the rabies virus dates back four millennia, with the virus being considered by many to be the first known transmitted between animals and humans.
Luzia H. Queiroz, Angélica C. A. Campos, Marissol C. Lopes, Elenice M. S. Cunha, Avelino Albas, Cristiano de Carvalho, Wagner A. Pedro, Eduardo C. Silva, Monique S. Lot, Sandra V. Inácio, Danielle B. Araújo, Marielton P. Cunha, Edison L. Durigon, Luiz Gustavo B. Góes, Silvana R. Favoretto   +14 more
doaj   +1 more source

Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen. [PDF]

The pathogenesis of HIV-1 infection is governed by a highly dynamic, time-dependent interaction between the host and the viral genome. In this study, we developed a novel systematic approach to assess the host-virus interaction, using average pairwise ...
Notter, Julia, Zeeb, Marius, Günthard, Huldrych F, Kouyos, Roger D, Metzner, Karin J, Neumann, Kathrin, Hoffmann, Matthias, Fellay, Jacques, Frischknecht, Paul, Rauch, Andri, Stöckle, Marcel, Pasin, Chloé, Thorball, Christian W, Leeman, Christine, Neuner-Jehle, Nadia, Perreau, Matthieu, Huber, Michael, Bernasconi, Enos, Leuzinger, Karoline   +18 more
core   +1 more source

HIV Types, Groups, Subtypes and Recombinant Forms: Errors in Replication, Selection Pressure and Quasispecies [PDF]

, 2012
HIV-1 is a chimpanzee virus which was transmitted to humans by several zoonotic events resulting in infection with HIV-1 groups M P, and in parallel transmission events from sooty mangabey monkey viruses leading to infections with HIV-2 groups A H.
Eberle, Josef, Gürtler, Lutz
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Paving the Way to Unveil the Diversity and Evolution of Phage Genomes

Viruses, 2020
Phage biology has been developing for the last hundred years, and the potential of phages as tools and treatments has been known since their early discovery.
Alejandro Reyes, Martha J. Vives
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Aedes aegypti from Amazon Basin Harbor High Diversity of Novel Viral Species

Viruses, 2020
Viruses are the most diverse and abundant microorganisms on earth, highly adaptive to a wide range of hosts. Viral diversity within invertebrate hosts has gained notoriety in recent years in public health as several such viruses have been of medical ...
Geovani de Oliveira Ribeiro, Vanessa S. Morais, Fred Julio Costa Monteiro, Edcelha Soares D’Athaide Ribeiro, Marlisson Octavio da S Rego, Raimundo Nonato Picanço Souto, Fabiola Villanova, Roozbeh Tahmasebi, Philip Michael Hefford, Xutao Deng, Eric Delwart, Ester Cerdeira Sabino, Licia Natal Fernandes, Antonio Charlys da Costa, Élcio Leal   +14 more
doaj   +1 more source

Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection

, 2002
Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in
Ogg, GS, Antonio Bertoletti, Brown, D., Dusheiko, G., Brown, D, Geoff Dusheiko, Williams, R., George J.M. Webster, Webster, GJ, Seneviratne, SL, Webster, G.J.M., Reignat, S, David Brown, Mala K. Maini, Stephanie Reignat, King, A., Dusheiko, G, Maini, MK, Bertoletti, A, Suranjith L. Seneviratne, Roger Williams, King, A, Bertoletti, A., Reignat, S., Williams, R, Maini, M.K., Graham S. Ogg, Abigail King, Ogg, G.S., Seneviratne, S.L.   +29 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source