Results 61 to 70 of about 2,646,395 (299)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

High temporal and spatial diversity in marine RNA viruses implies that they have an important role in mortality and structuring plankton communities

Frontiers in Microbiology, 2014
Viruses in the order Picornavirales infect eukaryotes, and are widely distributed in coastal waters. Amplicon deep-sequencing of the RNA dependent RNA polymerase (RdRp) revealed diverse and highly uneven communities of picorna-like viruses in the coastal
Julia Anne Gustavsen, Danielle M Winget, Xi eTian, Curtis A Suttle, Curtis A Suttle, Curtis A Suttle   +5 more
doaj   +1 more source

RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature

Microbiology Spectrum, 2022
The virus-encoded RNA-dependent RNA polymerase (RdRp) is responsible for viral replication, and its fidelity is closely related to viral diversity, pathogenesis, virulence, and fitness.
Shuyi Chen, Jiqin Wu, Xiaofeng Yang, Qiuli Sun, Su Liu, Farooq Rashid, Emmanuel Enoch Dzakah, Haiying Wang, Jufang Wang, Peng Gong, Shixing Tang   +10 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Virome of Terrestrial Mammals and Bats from Southern Brazil: Circulation of New Putative Members of the Togaviridae Family and Other Findings

Pathogens
The surveillance of wildlife viromes is essential for identifying zoonotic threats within the One Health framework. This study analyzed rectal and oral swabs from 88 individuals representing 13 species as felids, wild rodents, marsupials and non-human ...
Julyana Sthéfanie Simões Matos, Meriane Demoliner, Juliana Schons Gularte, Micheli Filippi, Vyctoria Malayhka de Abreu Góes Pereira, Mariana Soares da Silva, Matheus Nunes Weber, Marcelo Pereira de Barros, Fernando Rosado Spilki   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Relationship between viral load and nucleotide diversity.

, 2014
(A) Synonymous nucleotide diversity (πS) and (B) nonsynonymous nucleotide diversity (πN) were plotted against log-transformed viral loads for both SHFV-krc1 (green) and SHFV-krc2 (purple) infections. A significant correlation between nucleotide diversity
Adam L. Bailey (355743), Andrea Weiler (540110), David Hyeroba (352708), Michael Gleicher (540115), Geoffrey Weny (352710), Michael Correll (540114), Jens H. Kuhn (200537), Alex Tumukunde (352709), Zachary Bergman (540112), Michael Lauck (126211), Austin L. Hughes (36141), David H. O'Connor (49028), Samuel D. Sibley (540111), Thomas C. Friedrich (36124), Tony L. Goldberg (209089), Chase W. Nelson (540113), Jorge M. Dinis (216948), Colin Chapman (540116)   +17 more
core   +1 more source

Concurrent Circulation of Viral Agents in Pediatric Patients Presenting with Respiratory Illness and Diarrheal Symptoms in Metropolitan Region of São Paulo, Brazil, 2021

Viruses
Pneumonia and diarrhea are the leading causes of death in children under 5 globally, worsened by viral infections. This study investigates viral agents in children ≤ 3 years with respiratory illness and diarrhea in Metropolitan Region of São Paulo ...
Adriana Luchs, Natanael Sutikno Adiwardana, Leonardo Cecilio da Rocha, Ellen Viana, Simone Guadagnucci, Adriana Parise, Vanessa Cristina Martins Silva, Lais Sampaio de Azevedo, Raquel Guiducci, Yasmin França, Natacha Luana Pezzuol Frank, Ana Lucia Nascimento da Silva, Andre Luiz Vianna de Oliveira, André Henrique Souza Azevedo, Bárbara Segatelli Carreteiro, Maurício Lacerda Nogueira   +15 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source