Results 131 to 140 of about 60,752 (282)

The emergence of JN.1 variant resurgent COVID-19 wave in India and South Asia is a global public health concern

Journal of Infection and Public Health
The emergence of the JN.1 variant of SARS-CoV-2 has heightened global health concerns. Here, we aimed to evaluate viral characteristics, epidemiology, transmissibility, infectivity, immune evasion, effectiveness of current antiviral therapies ...
Najibah Nasrin, Asfia Hasan Mumu, Abir Hasan Pranto, Md. Rabiul Islam   +3 more
doaj   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Surveillance and Epidemiology of Viral Hemorrhagic Fevers (VHFs) : identification of emergence, seroprevelance, and risk factors of VHFs in Uganda

Surveillance et épidémiologie des fièvres hémorragiques virales (FHV) : identification de l'émergence, de la séroprévelance et des facteurs de risque des FVH en Ouganda Les fièvres hémorragiques virales (FHV) constituent un groupe de maladies causées principalement par des virus à ARN. Ils infectent à la fois les humains et les animaux (
openaire   +2 more sources

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

An Update on RNA Virus Discovery: Current Challenges and Future Perspectives

Viruses
The relentless emergence of RNA viruses poses a perpetual threat to global public health, necessitating continuous efforts in surveillance, discovery, and understanding of these pathogens.
Humberto Debat, Nicolas Bejerman
doaj   +1 more source

Anticipating the species jump: Surveillance for emerging viral threats [PDF]

International Journal of Infectious Diseases, 2010
openaire   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Swine influenza A virus subtype H1N2 in Sweden [PDF]

, 2012
The influenza A virus subtypes H1N1, H1N2 and H3N2 are prevalent in pig populations worldwide. All scientific data point towards swine as the key host species when new human influenza pandemics arise.
Metreveli, Giorgi
core   +1 more source

Risk management externalities in agrifood supply chains

American Journal of Agricultural Economics, EarlyView.
Abstract Firms may under‐ or over‐invest in risk management from the social planner's perspective, resulting in a negative externality on other economic agents in the supply chain. The externality of risk management is particularly relevant for agrifood supply chains, which frequently experience disruptions and play a primary role in preventing major ...
Jeffrey Hadachek, Meilin Ma
wiley   +1 more source

Monitoring viral evolution and epidemiological characteristics of SARS-CoV-2 during 2022–2023 using Integrated Genomic Surveillance

Communications Medicine
Background The continued emergence of SARS-CoV-2 variants with increased transmissibility and immunoevasive properties highlights the necessity to complement genomic surveillance with epidemiological data and laboratory-based assessment of viral ...
Christin Mache, Romy Kerber, Jessica Schulze, Marie Lataretu, Susan Abunijela, Yusra Seyam, Sofia Paraskevopoulou, Djin-Ye Oh, Maximilian Arlt, Aleksandar Radonić, Somayyeh Sedaghatjoo, Matthias Budt, Ann-Sophie Lehfeld, Felix Hartkopf, Ralf Dürrwald, Torsten Semmler, Walter Haas, Stephan Fuchs, Stefan Kröger, Thorsten Wolff, Integrated Molecular Surveillance for SARS-CoV-2 (IMSSC2) Laboratory Network   +20 more
doaj   +1 more source