Results 91 to 100 of about 1,846,216 (386)

Dynein Regulators Are Important for Ecotropic Murine Leukemia Virus Infection [PDF]

, 2016
Indexación: Web of Science.During the early steps of infection, retroviruses must direct the movement of the viral genome into the nucleus to complete their replication cycle.
Arriagada, Gloria, Cancino, Jorge, Goff, Stephen P., Opazo, Tatiana, Valle-Tenney, Roger   +4 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses

mBio, 2018
Receptor-mediated endocytosis is a cellular process commonly hijacked by viruses to enter cells. The stages of entry are well described for certain viruses, but the host factors that mediate each step are less well characterized. We previously identified
Nicholas Rinkenberger, John W. Schoggins
doaj   +1 more source

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice [PDF]

, 2015
Objective: Direct-acting antivirals (DAAs) inhibit hepatitis C virus (HCV) infection by targeting viral proteins that play essential roles in the replication process. However, selection of resistance-associated variants (RAVs) during DAA therapy has been
Ball, Jonathan K., Baumert, Thomas, Bhuju, Sabin, Brown, Richard J.P., Cortese, Riccardo, Doerrbecker, Juliane, Farhoudi, Ali, Geffers, Robert, Leroux-Roels, Geert, McClure, C. Patrick, Mesalam, Ahmed Atef, Meuleman, Philip, Nicosia, Alfredo, Pietschmann, Thomas, Troise, Fulvia, Van Den Eede, Naomi, Vercauteren, Koen, Verhoye, Lieven   +17 more
core   +4 more sources

Filovirus Tropism: Cellular Molecules for Viral Entry [PDF]

Frontiers in Microbiology, 2012
In human and non-human primates, filoviruses (Ebola and Marburg viruses) cause severe hemorrhagic fever. Recently, other animals such as pigs and some species of fruit bats have also been shown to be susceptible to these viruses. While having a preference for some cell types such as hepatocytes, endothelial cells, dendritic cells, monocytes, and ...
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Non-viral approaches to gene therapy [PDF]

, 1993
Several advances in non-viral gene transfer technology have been reported over the past year. Cationic lipids have been successfully used to deliver genes in vivo, providing a clear alternative to recombinant viruses.
Behr, Behr, Blumenthal, Böttger, Cotten, Cotten, Cotten, Cristiano, Curiel, Demeneix, Ellens, Felgner, Felgner, Fitzgerald, Haensler, Haensler, Hawley-Nelson, Huckett, Hyde, Kaneda, Legendre, Leonetri, Midoux, Nabel, Parente, Plank, Plautz, Rosenkranz, Seth, Shen, Stribling, Subbarao, Tang, Tomita, Trubetskoy, Trubetskoy, Ulmer, Wagner, Wagner, Wagner, Wagner, Wagner, Williams, Wu, Zhu   +44 more
core   +1 more source

IFITM proteins—cellular inhibitors of viral entry

Current Opinion in Virology, 2014
Interferon inducible transmembrane (IFITM) proteins are a recently discovered family of cellular anti-viral proteins that restrict the replication of a number of enveloped and non-enveloped viruses. IFITM proteins are located in the plasma membrane and endosomal membranes, the main portals of entry for many viruses.
SE Smith, S Weston, P Kellam, M Marsh
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

HIV-1 Diversity in the Envelope Glycoproteins: Implications for Viral Entry Inhibition

Viruses, 2013
Entry of HIV-1 into a host cell is a multi-step process, with the viral envelope gp120 and gp41 acting sequentially to mediate the viral attachment, CD4 binding, coreceptor binding, and fusion of the viral and host membranes.
Sabrina E. M. Almeida, Leonardo Augusto Luvison Araújo   +1 more
doaj   +1 more source