Results 241 to 250 of about 2,207,666 (298)

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Broad-spectrum synthetic carbohydrate receptors (SCRs) inhibit viral entry across multiple virus families. [PDF]

Sci Adv
Ezzatpour S, Thakur K, Erzoah Ndede K, Buchholz DW, Choi A, Imbiakha B, Carter J, Onofrei D, Eaton B, Postnikova E, Murphy M, Tapia BC, Bello D, Pasari S, Russo A, Babayev M, Holland GP, Holbrook MR, Caddy SL, Moran SJ, Davachi SM, Monreal IA, Sahler J, Ortega V, Miranda JM, Whittaker GR, Jager MC, Bhagwat SK, Chopra P, Jan-Boons G, Marianski M, Braunschweig AB, Aguilar HC.   +32 more
europepmc   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

5,6-dihydroxyflavone exerts anti-betacoronavirus activity by blocking viral entry to host cells. [PDF]

Virus Res
Cao Y, Lai KM, Zheng H, Tan YJ, Huang D.
europepmc   +1 more source

Antigenic and mutational insights into the Nipah virus G glycoprotein: implications for viral entry, host specificity, therapeutics, and vaccine development. [PDF]

PeerJ
Mohamad Nasir NS, Ismadi YKM, Semail N, Wan Alias WAS, Nik Zuraina NMN, Yusof NY, Deris ZZ, Salleh MZ.   +7 more
europepmc   +1 more source

Computational discovery of SARS-CoV-2 viral entry inhibitory peptides from <i>Androctonus mauretanicus</i> scorpion venom: molecular docking and molecular dynamics simulations targeting the spike protein. [PDF]

Front Bioinform
Chahir R, Redouane S, Galan J, Hboub H, Aserrar L, Chakir S, Lahlou AS, Aassila H, El Fatimy R, Oukkache N.   +9 more
europepmc   +1 more source

Correction: Computational discovery of SARS-CoV-2 viral entry inhibitory peptides from <i>Androctonus mauretanicus</i> scorpion venom: molecular docking and molecular dynamics simulations targeting the spike protein. [PDF]

Front Bioinform
Chahir R, Redouane S, Galan J, Hboub H, Aserrar L, Chakir S, Lahlou AS, Aassila H, El Fatimy R, Oukkache N.   +9 more
europepmc   +1 more source

Tetraspanin SfCD9 as a Key Membrane Binding Factor of SRBSDV P10 Facilitates Viral Entry Into Sogatella furcifera Midgut Epithelial Cells via Clathrin-Mediated Endocytosis. [PDF]

Mol Plant Pathol
Gao S, Li L, Zeng M, Xie L, Li J, Zhou X, Wu J.   +6 more
europepmc   +1 more source

Alpha Linolenic and Stearic Acids Modulate Genes Related to Viral Entry and Inflammatory Response in THP-1 Derived Macrophages Exposed to SARS-CoV-2. [PDF]

Food Sci Nutr
Maia AR, Dos Santos Silva BR, Parise PL, Simeoni CL, Meira LS, Módena JLP, Araújo EP, Velloso LA, Anhê GF, Morari J.   +9 more
europepmc   +1 more source