Results 241 to 250 of about 2,147,758 (302)

Broad-spectrum synthetic carbohydrate receptors (SCRs) inhibit viral entry across multiple virus families. [PDF]

Sci Adv
Ezzatpour S, Thakur K, Erzoah Ndede K, Buchholz DW, Choi A, Imbiakha B, Carter J, Onofrei D, Eaton B, Postnikova E, Murphy M, Tapia BC, Bello D, Pasari S, Russo A, Babayev M, Holland GP, Holbrook MR, Caddy SL, Moran SJ, Davachi SM, Monreal IA, Sahler J, Ortega V, Miranda JM, Whittaker GR, Jager MC, Bhagwat SK, Chopra P, Jan-Boons G, Marianski M, Braunschweig AB, Aguilar HC.   +32 more
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

5,6-dihydroxyflavone exerts anti-betacoronavirus activity by blocking viral entry to host cells. [PDF]

Virus Res
Cao Y, Lai KM, Zheng H, Tan YJ, Huang D.
europepmc   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Antigenic and mutational insights into the Nipah virus G glycoprotein: implications for viral entry, host specificity, therapeutics, and vaccine development. [PDF]

PeerJ
Mohamad Nasir NS, Ismadi YKM, Semail N, Wan Alias WAS, Nik Zuraina NMN, Yusof NY, Deris ZZ, Salleh MZ.   +7 more
europepmc   +1 more source

Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone

Advanced Science, EarlyView.
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei   +12 more
wiley   +1 more source

Computational discovery of SARS-CoV-2 viral entry inhibitory peptides from <i>Androctonus mauretanicus</i> scorpion venom: molecular docking and molecular dynamics simulations targeting the spike protein. [PDF]

Front Bioinform
Chahir R, Redouane S, Galan J, Hboub H, Aserrar L, Chakir S, Lahlou AS, Aassila H, El Fatimy R, Oukkache N.   +9 more
europepmc   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Correction: Computational discovery of SARS-CoV-2 viral entry inhibitory peptides from <i>Androctonus mauretanicus</i> scorpion venom: molecular docking and molecular dynamics simulations targeting the spike protein. [PDF]

Front Bioinform
Chahir R, Redouane S, Galan J, Hboub H, Aserrar L, Chakir S, Lahlou AS, Aassila H, El Fatimy R, Oukkache N.   +9 more
europepmc   +1 more source