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Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry [PDF]
FEBS Journal, 2009 Herpes simplex virus type‐1 and type‐2 are highly prevalent human pathogens causing life‐long infections. The process of infection begins when the virions bind heparan sulfate moieties present on host cell surfaces. This initial attachment then triggers a cascade of molecular interactions involving multiple viral and host cell proteins and receptors ...
Deepak Shukla, Jihan Akhtar
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Role of Protein–Lipid Interactions in Viral Entry
Advanced Biology, 2022AbstractThe viral entry consists of several sequential events that ensure the attachment of the virus to the host cell and the introduction of its genetic material for the continuation of the replication cycle. Both cellular and viral lipids have gained a wider focus in recent years in the field of viral entry, as they are found to play key roles in ...
Maier Lorizate +2 more
exaly +4 more sources
Annual Review of Cell and Developmental Biology, 2000
▪ Abstract Because many viruses replicate in the nucleus of their host cells, they must have ways of transporting their genome and other components into and out of this compartment. For the incoming virus particle, nuclear entry is often one of the final steps in a complex transport and uncoating program.
G R, Whittaker, M, Kann, A, Helenius
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▪ Abstract Because many viruses replicate in the nucleus of their host cells, they must have ways of transporting their genome and other components into and out of this compartment. For the incoming virus particle, nuclear entry is often one of the final steps in a complex transport and uncoating program.
G R, Whittaker, M, Kann, A, Helenius
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2005
Virus entry is initiated by recognition by receptors present on the surface of host cells. Receptors can be major mediators of virus tropism, and in many cases receptor interactions occur in an apparently programmed series of events utilizing multiple receptors.
S B, Sieczkarski, G R, Whittaker
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Virus entry is initiated by recognition by receptors present on the surface of host cells. Receptors can be major mediators of virus tropism, and in many cases receptor interactions occur in an apparently programmed series of events utilizing multiple receptors.
S B, Sieczkarski, G R, Whittaker
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Tight Junctions and Viral Entry
Future Virology, 2010A wide variety of different viruses use tight junction (TJ) proteins in the course of infection and different mechanisms of pathogen–TJ interactions have been described; pathogens may induce the reorganization or degradation of distinct TJ proteins, reorganization of the cell cytoskeleton, activation of host-cell signaling pathways and/or use TJ ...
ZEISEL M.B., TUREK M., BAUMERT T.F.
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Common Principles in Viral Entry
Annual Review of Microbiology, 2002▪ Abstract Viruses occur throughout the biosphere. Cells of Eukarya, Bacteria, and Archaea are infected by a variety of viruses that considerably outnumber the host cells. Although viruses have adapted to different host systems during evolution and many different viral strategies have developed, certain similarities can be found.
Minna M, Poranen +2 more
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2015
Epstein-Barr virus primarily, though not exclusively, infects B cells and epithelial cells. Many of the virus and cell proteins that are involved in entry into these two cell types in vitro have been identified, and their roles in attachment and fusion are being explored.
Liudmila S, Chesnokova +2 more
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Epstein-Barr virus primarily, though not exclusively, infects B cells and epithelial cells. Many of the virus and cell proteins that are involved in entry into these two cell types in vitro have been identified, and their roles in attachment and fusion are being explored.
Liudmila S, Chesnokova +2 more
openaire +2 more sources
2008
The entry of viruses into target cells involves a complex series of sequential steps, with opportunities for inhibition at every stage. Entry inhibitors exert their biological properties by inhibiting protein-protein interactions either within the viral envelope (Env) glycoproteins or between viral Env and host-cell receptors.
Tom, Melby, Mike, Westby
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The entry of viruses into target cells involves a complex series of sequential steps, with opportunities for inhibition at every stage. Entry inhibitors exert their biological properties by inhibiting protein-protein interactions either within the viral envelope (Env) glycoproteins or between viral Env and host-cell receptors.
Tom, Melby, Mike, Westby
openaire +2 more sources
AIP Conference Proceedings, 2010
Successful viral infection of a healthy cell requires complex host‐pathogen interactions. In this talk we focus on the dynamics specific to the HIV virus entering a eucaryotic cell. We model viral entry as a stochastic engagement of receptors and coreceptors on the cell surface.
Maria R. D’Orsogna +3 more
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Successful viral infection of a healthy cell requires complex host‐pathogen interactions. In this talk we focus on the dynamics specific to the HIV virus entering a eucaryotic cell. We model viral entry as a stochastic engagement of receptors and coreceptors on the cell surface.
Maria R. D’Orsogna +3 more
openaire +1 more source