Results 251 to 260 of about 299,371 (295)

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Single Amino Acid Residue W33 of tva Receptor Is Critical for Viral Entry and High-Affinity Binding of Avian Leukosis Virus Subgroup K. [PDF]

Viruses
Gáliková E, Přikryl D, Prost S, Kučerová D, Trejbalová K, Hejnar J.   +5 more
europepmc   +1 more source

TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry. [PDF]

PLoS Pathog
Xie Y, Cao J, Gan S, Xu L, Zhang D, Qian S, Xu F, Ding Q, Schoggins JW, Fan W.   +9 more
europepmc   +1 more source

Oncolytic virotherapy against lung cancer: key receptors and signaling pathways of viral entry. [PDF]

Front Immunol
Dong W, Luo Y, He D, Zhang M, Zeng J, Chen Y.   +5 more
europepmc   +1 more source

Senescence of endothelial cells increases susceptibility to Kaposi's sarcoma-associated herpesvirus infection via CD109-mediated viral entry. [PDF]

J Clin Invest
Lee MJ, Yeon JH, Lee J, Kang YH, Park BS, Park J, Yun SH, Wirth D, Yoo SM, Park C, Gao SJ, Lee MS.   +11 more
europepmc   +1 more source

Protective Effects of Liposomal Vitamin C on SARS-CoV-2 Target Viral Entry Genes in Renal Cells. [PDF]

Rep Biochem Mol Biol
Behmardi A, Zolghadr L, Rajaei F, Gholamzadeh Khoei S, Gheibi N.   +4 more
europepmc   +1 more source

KCNE4 is a crucial host factor for Orf virus infection by mediating viral entry. [PDF]

Virol J
Sun J, Ding Y, Zhou Q, Kalds P, Han J, Zhang K, Wei Y, Wu W, Wang X, Zheng W.   +9 more
europepmc   +1 more source

Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry [PDF]

FEBS Journal, 2009
Herpes simplex virus type‐1 and type‐2 are highly prevalent human pathogens causing life‐long infections. The process of infection begins when the virions bind heparan sulfate moieties present on host cell surfaces. This initial attachment then triggers a cascade of molecular interactions involving multiple viral and host cell proteins and receptors ...
Deepak Shukla
exaly   +3 more sources