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Viral Entry

Epstein-Barr virus chiefly infects B cells and epithelial cells but is capable of infecting other cell types in the human host. Host cell entry is a complex process mediated by several viral glycoproteins that define tropism and mediate membrane fusion.
Samantha, Hardy   +3 more
openaire   +2 more sources

Henipavirus Membrane Fusion and Viral Entry

2012
Nipah (NiV) and Hendra (HeV) viruses cause cell-cell fusion (syncytia) in brain, lung, heart, and kidney tissues, leading to encephalitis, pneumonia, and often death. Membrane fusion is essential to both viral entry and virus-induced cell-cell fusion, a hallmark of henipavirus infections.
Hector C, Aguilar, Ronald M, Iorio
openaire   +2 more sources

HIV-1 cell entry and advances in viral entry inhibitor therapy

Journal of Clinical Virology, 2003
Despite the considerable successes of highly active antiretroviral therapy, new classes of therapeutic agents are still urgently needed. Unfortunately, the emergence of antiviral resistance and drug toxicity remain challenging obstacles to successful treatment in many HIV-1-infected individuals. HIV-1 entry is a multi-step process that is an attractive
Louise A, Cooley, Sharon R, Lewin
openaire   +2 more sources

A Gatekeeper of Viral Entry

Science Signaling, 2012
The receptor EphrinA2 promotes herpesvirus entry into endothelial cells.
openaire   +1 more source

Nonenveloped Capsid: Mechanisms of Viral Entry

Future Virology, 2014
ABSTRACT  Viruses are a diverse class of nanoparticles. However, they have evolved a few common mechanisms that enable successful infection of their host cells. The first stage of this process involves entry into the cell. For enveloped viruses this process has been well characterized.
Bridget Lins, Mavis Agbandje-McKenna
openaire   +1 more source

Viral Entry into Host Cells

2013
Attachment Factors.- Picornavirus Entry.- Reovirus Receptors, Cell Entry, and Proapoptotic Signaling.- Entry of Influenza Virus.- Filovirus Entry.- Paramyxovirus Entry.- Cellular entry of retroviruses.- Class II Fusion Proteins.- Entry of Rhabdoviruses into Animal Cells.- Entry of Herpesviruses into Cells: The Enigma Variations.
openaire   +1 more source

Neutralizing antibodies to block viral entry and for identification of entry inhibitors

Antiviral Research
Neutralizing antibodies (NAbs) are naturally produced by our immune system to combat viral infections. Clinically, neutralizing antibodies with potent efficacy and high specificity have been extensively used to prevent and treat a wide variety of viral infections, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Human ...
Ee Hong Tam   +4 more
openaire   +2 more sources

Viral and host heterogeneity and their effects on the viral life cycle

Nature Reviews Microbiology, 2020
Jennifer E Jones, Valerie Le Sage
exaly  

The structural basis of herpesvirus entry

Nature Reviews Microbiology, 2020
Sarah A Connolly   +2 more
exaly  

A molecular understanding of alphavirus entry and antibody protection

Nature Reviews Microbiology, 2022
Arthur S Kim, Michael Diamond
exaly  

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