Results 271 to 280 of about 299,371 (295)

HIV-Resistance to Viral Entry Inhibitors

Current Pharmaceutical Design, 2004
An increasing number of human immunodeficiency virus (HIV)-infected patients have detectable viraemia despite treatment with multiple-drug combinations or have developed resistance to all available classes of antiretroviral therapy. HIV entry has become an important pharmacological target. Enfuvirtide is the first HIV entry inhibitor to be approved for
Luis, Menéndez-Arias, José A, Esté
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An Enzymatic Assay for Detection of Viral Entry

Current Protocols in Cell Biology, 2011
AbstractThis unit describes a viral entry assay where a beta‐lactamase reporter protein fused to the matrix protein of either influenza (BlaM1) or ebola virus (BlaVP40) is packaged as a structural component into virus‐like particles (VLPs). The Bla reporter is released upon fusion with target cells and can be detected in live cells by flow cytometry ...
Donna M, Tscherne, Adolfo, García-Sastre   +1 more
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The importance of viral and cellular factors on flavivirus entry

Current Opinion in Virology, 2021
The flavivirus are emerging and re-emerging arthropod-borne pathogens responsible for significant mortality and morbidity worldwide. The genus comprises more than 70 viruses, and despite genomic and structural similarities, infections by different flaviviruses result in different clinical presentations.
Carlos Daniel Cordero-Rivera, Luis Adrián De Jesús-González, Juan Fidel Osuna-Ramos, Selvin Noé Palacios-Rápalo, Carlos Noe Farfan-Morales, José Manuel Reyes-Ruiz, Rosa María Del Ángel   +6 more
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Neutralizing antibodies to block viral entry and for identification of entry inhibitors

Antiviral Research
Neutralizing antibodies (NAbs) are naturally produced by our immune system to combat viral infections. Clinically, neutralizing antibodies with potent efficacy and high specificity have been extensively used to prevent and treat a wide variety of viral infections, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Human ...
Jianqing Peng, C Yan, Tianshu Xiao
exaly   +3 more sources

A Gatekeeper of Viral Entry

Science Signaling, 2012
The receptor EphrinA2 promotes herpesvirus entry into endothelial cells.
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Viral Entry

Epstein-Barr virus chiefly infects B cells and epithelial cells but is capable of infecting other cell types in the human host. Host cell entry is a complex process mediated by several viral glycoproteins that define tropism and mediate membrane fusion.
Samantha, Hardy, Crystal B, Chhan, Amelia R, Davis, Andrew T, McGuire   +3 more
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Henipavirus Membrane Fusion and Viral Entry

2012
Nipah (NiV) and Hendra (HeV) viruses cause cell-cell fusion (syncytia) in brain, lung, heart, and kidney tissues, leading to encephalitis, pneumonia, and often death. Membrane fusion is essential to both viral entry and virus-induced cell-cell fusion, a hallmark of henipavirus infections.
Hector C, Aguilar, Ronald M, Iorio
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The intersection of viral mimicry and nuclear entry

Trends in Biochemical Sciences
The nuclear pore complex (NPC) facilitates macromolecular exchange between the cytoplasm and nucleus; the selective nature of which is vital to proper cell functioning. Many DNA and some RNA viruses must also access the host nucleus for successful replication and have evolved numerous strategies for this purpose, the most common of which is mimicry of ...
Claire F. Dickson, Prabhjeet Phalora, David A. Jacques   +2 more
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HIV-1 cell entry and advances in viral entry inhibitor therapy

Journal of Clinical Virology, 2003
Despite the considerable successes of highly active antiretroviral therapy, new classes of therapeutic agents are still urgently needed. Unfortunately, the emergence of antiviral resistance and drug toxicity remain challenging obstacles to successful treatment in many HIV-1-infected individuals. HIV-1 entry is a multi-step process that is an attractive
Louise A, Cooley, Sharon R, Lewin
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Viral Entry into Host Cells

2013
Attachment Factors.- Picornavirus Entry.- Reovirus Receptors, Cell Entry, and Proapoptotic Signaling.- Entry of Influenza Virus.- Filovirus Entry.- Paramyxovirus Entry.- Cellular entry of retroviruses.- Class II Fusion Proteins.- Entry of Rhabdoviruses into Animal Cells.- Entry of Herpesviruses into Cells: The Enigma Variations.
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