MARCH8 Targets Cytoplasmic Lysine Residues of Various Viral Envelope Glycoproteins [PDF]
Microbiology Spectrum, 2022 The host transmembrane protein MARCH8 is a RING finger E3 ubiquitin ligase that downregulates various host transmembrane proteins, such as MHC-II. We have recently reported that MARCH8 expression in virus-producing cells impairs viral infectivity by ...
Yanzhao Zhang +7 more
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Role of Viral Envelope Proteins in Determining Susceptibility of Viruses to IFITM Proteins [PDF]
VirusesInterferon-induced transmembrane proteins (IFITMs) are a family of proteins which inhibit infections of various enveloped viruses. While their general mechanism of inhibition seems to be non-specific, involving the tightening of membrane structures to ...
Thomas Marceau, Martine Braibant
doaj +2 more sources
Heterogeneous Condensation on Simplified Viral Envelope Protein Structures. [PDF]
ACS Appl Mater InterfacesElucidating the mechanisms of heterogeneous condensation on viral and bacterial envelopes is crucial for understanding biothreat transport phenomena and optimizing capture efficiency in condensation-based detection devices. We investigate the impact of viral envelope geometric parameters [e.g., surface structure pitch-to-diameter ratio (p/d)] due to ...
Ahasan K +3 more
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MARCH8 targets cytoplasmic lysine residues of various viral envelope glycoproteins [PDF]
Microbiology Spectrum, 2021 The host transmembrane protein MARCH8 is a RING finger E3 ubiquitin ligase that downregulates various host transmembrane proteins, such as MHC-II. We have recently reported that MARCH8 expression in virus-producing cells impairs viral infectivity by reducing virion incorporation of not only HIV-1 envelope glycoproteins but also vesicular stomatitis ...
Zhang Y +7 more
europepmc +4 more sources
Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers. [PDF]
J Am Chem Soc, 2020 Broad-spectrum antivirals are powerful weapons against dangerous viruses where no specific therapy exists, as in the case of the ongoing SARS-CoV-2 pandemic. We discovered that a lysine- and arginine-specific supramolecular ligand (CLR01) destroys enveloped viruses, including HIV, Ebola, and Zika virus, and remodels amyloid fibrils in semen that ...
Weil T +31 more
europepmc +8 more sources
Human immunoglobulins are transported to HCMV viral envelope by viral Fc gamma receptors-dependent and independent mechanisms. [PDF]
Front Microbiol, 2022 Vezzani G +9 more
europepmc +3 more sources
Viral envelope protein 53R gene highly specific silencing and iridovirus resistance in fish Cells by AmiRNA. [PDF]
PLoS ONE, 2010 BACKGROUND: Envelope protein 53R was identified from frog Rana grylio virus (RGV), a member of the family Iridoviridae, and it plays an important role in the virus assembly.
Yu-Sin Kim +4 more
doaj +3 more sources
Brilacidin as a Broad-Spectrum Inhibitor of Enveloped, Acutely Infectious Viruses
Microorganisms, 2023 Alphaviruses, belonging to the Togaviridae family, and bunyaviruses, belonging to the Paramyxoviridae family, are globally distributed and lack FDA-approved vaccines and therapeutics.
Carol A. Anderson +5 more
doaj +1 more source
Emerging Microbes and Infections, 2023 Viral envelope glycoproteins are crucial for viral infections. In the process of enveloped viruses budding and release from the producer cells, viral envelope glycoproteins are presented on the viral membrane surface as spikes, promoting the virus's next-
Changqing Yu +7 more
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