Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death
The FEBS Journal, EarlyView.Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa +4 more
wiley +1 more source
The FEBS Journal, EarlyView.Current methods to control porcine reproductive and respiratory syndrome, a disease affecting pigs, are insufficient and a safer, more effective vaccine is needed. This study describes the design and plant production of a self‐assembling protein nanoparticle vaccine candidate against this disease.
Jordan T. VanderBurgt +5 more
wiley +1 more source
SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity
The FEBS Journal, EarlyView.The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl +11 more
wiley +1 more source
Epitope Presentation of Dengue Viral Envelope Glycoprotein Domain III on Hepatitis B Core Protein Virus-Like Particles Produced in <i>Nicotiana benthamiana</i>. [PDF]
Front Plant Sci, 2019 Pang EL +7 more
europepmc +1 more source
The FEBS Journal, EarlyView.This study investigates the potential of encapsulin as an antigen display platform for the development of a candidate Salmonella vaccine for poultry. Encapsulin constructs were transiently expressed in Nicotiana benthamiana where they accumulated to high levels.
Carly A. Charron +6 more
wiley +1 more source
Full-Length Glycosylated Gag of Murine Leukemia Virus Can Associate with the Viral Envelope as a Type I Integral Membrane Protein. [PDF]
J Virol, 2018 Renner TM +5 more
europepmc +1 more source
The MMTV envelope glycoprotein promotes the survival and function of CD8 T cells during chronic viral infection and cancer via ITAM-dependent signaling 3439 [PDF]
Max Klapholz +7 more
openalex +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Hemagglutinin Spatial Distribution Shifts in Response to Cholesterol in the Influenza Viral Envelope. [PDF]
Biophys J, 2015 Domanska MK +5 more
europepmc +1 more source