Results 261 to 270 of about 162,149 (303)

Computational methods to study enveloped viral entry

Biochemical Society Transactions, 2021
The protein–membrane interactions that mediate viral infection occur via loosely ordered, transient assemblies, creating challenges for high-resolution structure determination. Computational methods and in particular molecular dynamics simulation have thus become important adjuncts for integrating experimental data, developing mechanistic models, and ...
Alzbeta Tuerkova, Peter M. Kasson
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Viral envelope glycoprotein processing by proprotein convertases

Antiviral Research, 2013
The proprotein convertases (PCs) are a family of nine mammalian enzymes that play key roles in the maintenance of cell homeostasis by activating or inactivating proteins via limited proteolysis under temporal and spatial control. A wide range of pathogens, including major human pathogenic viruses can hijack cellular PCs for their own purposes.
Pasquato Antonella, da Palma Joel Ramos, Galan Clara, Seidah Nabil G, Kunz Stefan   +4 more
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Reconstitution of Recombinant Viral Envelope Proteins

2003
Publisher Summary Liposomes comprising lipid bilayer membranes enclosing aqueous internal compartments serve as attractive models for reconstitution of a variety of membrane proteins such as viral envelope proteins. The lipid membranes consist of amphipathic lipids that are similar to those found in authentic cell membranes.
Christian, Oker-Blom, Matti, Vuento
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Pseudotyping Viral Vectors With Emerging Virus Envelope Proteins

Current Gene Therapy, 2016
Previously unidentified viruses, such as Middle East respiratory syndrome coronavirus, continue to emerge and threaten populations, while powerful new techniques have identified many new human and animal viruses. Similarly, existing viruses, from Ebola virus to chikungunya virus, are reemerging and spreading to new geographical regions.
Imke, Steffen, Graham, Simmons
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Changes in viral envelope structure preceding infection

Nature, 1976
THE first stage of infection by enveloped paramyxoviruses probably involves fusion of the viral envelope with the cell plasma membrane1. During the course of an in vitro investigation into the mechanism of cell–cell fusion induced by Sendai virus it has become apparent that prior to the membrane fusion event the viral envelope undergoes a dramatic ...
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Iscom of viral envelope proteins protects against Aujeszky's disease

Veterinary Microbiology, 1989
An immunostimulating complex (iscom) containing the envelope proteins of pseudorabies virus (PRV) was prepared and its efficacy was evaluated in two experiments on sheep. In the first experiment, sheep were intramuscularly (i.m.) or intradermally (i.d.) vaccinated with PRV iscom doses varying between 1 and 81 micrograms. The vaccination was repeated on
B, Morein, S, Belák, T, Soós, M, Rusvai, B S, McGwire, K, Bognár   +5 more
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The Packaging of Different Cargo into Enveloped Viral Nanoparticles

Molecular Pharmaceutics, 2012
Viral nanoparticles used for biomedical applications must be able to discriminate between tumor or virus-infected host cells and healthy host cells. In addition, viral nanoparticles must have the flexibility to incorporate a wide range of cargo, from inorganic metals to mRNAs to small molecules.
Fan, Cheng, Irina B, Tsvetkova, Y-Lan, Khuong, Alan W, Moore, Randy J, Arnold, Nancy L, Goicochea, Bogdan, Dragnea, Suchetana, Mukhopadhyay   +7 more
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(Patho)physiologic pathways to drug targeting: Artificial viral envelopes

Journal of Molecular Recognition, 1995
AbstractThe goal of this study was to exploit molecular recognition of cell surface receptors by viral surface glycoproteins as a means for the selective intracellular delivery of macromolecules. To accomplish this, artificial viral envelopes (AVE) resembling the human immunodeficiency virus‐1 (HIV‐1) were designed as a model system.
H, Schreier, M, Ausborn, S, Günther, V, Weissig, R, Chander   +4 more
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Viral Envelopes and Their Relationship to Cellular Membranes

1974
In recent years membrane structure and function have become a central issue in molecular biology, and viruses provide valuable model systems for such studies. The biogenesis of viruses depends almost completely on the biosynthetic apparatus of the host cell and cellular membranes are involved in many steps of viral replication.
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