Results 41 to 50 of about 255,758 (252)

Arms Race between Enveloped Viruses and the Host ERAD Machinery

Viruses, 2016
Enveloped viruses represent a significant category of pathogens that cause serious diseases in animals. These viruses express envelope glycoproteins that are singularly important during the infection of host cells by mediating fusion between the viral ...
Dylan A. Frabutt, Yong-Hui Zheng
doaj   +1 more source

Folding of Viral Envelope Glycoproteins in the Endoplasmic Reticulum [PDF]

Traffic, 2000
Viral glycoproteins fold and oligomerize in the endoplasmic reticulum of the host cell. They employ the cellular machinery and receive assistance from cellular folding factors. During the folding process, they are retained in the compartment and their structural quality is checked by the quality control system of the endoplasmic reticulum.
Braakman I, van Anken E
openaire   +3 more sources

Dynein Regulators Are Important for Ecotropic Murine Leukemia Virus Infection [PDF]

, 2016
Indexación: Web of Science.During the early steps of infection, retroviruses must direct the movement of the viral genome into the nucleus to complete their replication cycle.
Arriagada, Gloria, Cancino, Jorge, Goff, Stephen P., Opazo, Tatiana, Valle-Tenney, Roger   +4 more
core   +1 more source

Incorporation of Hepatitis C Virus E1 and E2 Glycoproteins: The Keystones on a Peculiar Virion

Viruses, 2014
Hepatitis C virus (HCV) encodes two envelope glycoproteins, E1 and E2. Their structure and mode of fusion remain unknown, and so does the virion architecture.
Gabrielle Vieyres, Jean Dubuisson, Thomas Pietschmann   +2 more
doaj   +1 more source

HIV-1 Envelope Glycoprotein Trafficking and Viral Transmission

Proceedings, 2020
HIV-1 encodes an envelope glycoprotein complex (Env) containing a long cytoplasmic tail (CT) harboring trafficking motifs implicated in Env incorporation into virions.
Melissa Victoria Fernandez, Lwar N Naing, David A Scheiblin, Sherimay D Ablan, Jennifer A Simmons, Eric O Freed   +5 more
doaj   +1 more source

The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein

iScience, 2023
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks multiple human proteins during infection and viral replication. To examine whether any viral proteins employ human E3 ubiquitin ligases, we evaluated the stability of SARS-CoV ...
Charles Zou, Hojong Yoon, Paul M.C. Park, J.J. Patten, Jesse Pellman, Jeannie Carreiro, Jonathan M. Tsai, Yen-Der Li, Shourya S. Roy Burman, Katherine A. Donovan, Jessica Gasser, Adam S. Sperling, Radosław P. Nowak, Eric S. Fischer, Robert A. Davey, Benjamin L. Ebert, Mikołaj Słabicki   +16 more
doaj   +1 more source

Scalable Analysis of Authentic Viral Envelopes on FRONTERA

Computing in Science & Engineering, 2020
AbstractEnveloped viruses infect host cells via fusion of their viral envelope with the plasma membrane. Upon cell entry, viruses gain access to all the macromolecular machinery necessary to replicate, assemble, and bud their progeny from the infected cell.
Gonzalez-Arias, Fabio, Reddy, Tyler, Stone, John E., Hadden-Perilla, Jodi A., Perilla, Juan R.   +4 more
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Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization

Cell Reports, 2018
Summary: Alphaviruses are enveloped pathogens that cause arthritis and encephalitis. Here, we report a 4.4-Å cryoelectron microscopy (cryo-EM) structure of eastern equine encephalitis virus (EEEV), an alphavirus that causes fatal encephalitis in humans ...
S. Saif Hasan, Chengqun Sun, Arthur S. Kim, Yasunori Watanabe, Chun-Liang Chen, Thomas Klose, Geeta Buda, Max Crispin, Michael S. Diamond, William B. Klimstra, Michael G. Rossmann   +10 more
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Viral coagulation: pushing the envelope

Journal of Thrombosis and Haemostasis
Many virus types affect the blood clotting system with correlations to pathology that range widely from thrombosis to hemorrhage linking to inflammation. Here we overview the intricate crosstalk induced by infection between proteins on the virus encoded by either the host or virus genomes, coagulation proteins, platelets, leukocytes, and endothelial ...
Edward Louis George Pryzdial, John Ruggles Perrier, Mahamud-Ur Rashid, Henry Euan West, Michael Ross Sutherland   +4 more
openaire   +2 more sources

An Endogenous Retrovirus from Human Hookworm Encodes an Ancient Phlebovirus-Like Class II Envelope Fusion Protein

Proceedings, 2020
Within the parasitic nematode Ancylostoma ceylanicum, a ~20 million-year-old Bel/Pao LTR retrotransposon encodes an ancient viral class II envelope fusion protein termed Atlas Gc.
Monique Merchant, Carlos P. Mata, Yorgo Modis   +2 more
doaj   +1 more source