Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure. [PDF]
PLoS Pathogens, 2011 Viral reservoirs that persist in HIV-1 infected individuals on antiretroviral therapy (ART) are the major obstacle to viral eradication. The identification and definition of viral reservoirs in patients on ART is needed in order to understand viral ...
Mark Sharkey +5 more
doaj +1 more source
Reduction of Influenza Virus Envelope’s Fusogenicity by Viral Fusion Inhibitors [PDF]
ACS Infectious Diseases, 2015 During cell entry of an enveloped virus, the viral membrane must be fused with the cellular membrane. The virus envelope has a unique structure consisting of viral proteins and a virus-specific lipid composition, whereas the host membrane has its own structure with host membrane proteins.
Rowse, Michael +5 more
openaire +3 more sources
Virology Journal, 2010 HIV-1 particle assembly mediated by viral Gag protein occurs predominantly at plasma membrane. While colocalization of HIV-1 envelope with lipid rich microenvironment have been shown in T cells, the significance of viral proteins modulating envelope ...
Bhattacharya Jayanta +2 more
doaj +1 more source
Nature Communications, 2023 Autophagy receptor NDP52 triggers bacterial autophagy against infection. However, the ability of NDP52 to protect against viral infection has not been established.
Shuzhi Cui +19 more
doaj +1 more source
Persistent hepatitis C virus infection in vitro: coevolution of virus and host. [PDF]
, 2006 The virological and cellular consequences of persistent hepatitis C virus (HCV) infection have been elusive due to the absence of the requisite experimental systems.
Cheng, Guofeng +7 more
core +3 more sources
Model for a novel membrane envelope in a filamentous hyperthermophilic virus
eLife, 2017 Biological membranes create compartments, and are usually formed by lipid bilayers. However, in hyperthermophilic archaea that live optimally at temperatures above 80°C the membranes are monolayers which resemble fused bilayers.
Peter Kasson +7 more
doaj +1 more source
Flavivirus Envelope Protein Glycosylation: Impacts on Viral Infection and Pathogenesis
Journal of Virology, 2020 Flaviviruses encode one, two, or no N -linked glycosylation sites on their envelope proteins. Glycosylation can impact virus interactions with cell surface attachment factors and also may impact virion stability and virus replication.
Derek L. Carbaugh, Helen M. Lazear
openaire +3 more sources
Nuclear inclusion of nontargeted and chromatin-targeted polystyrene beads and plasmid DNA containing nanoparticles [PDF]
, 2011 The nuclear membrane is one of the major cellular barriers in the delivery of plasmid DNA (pDNA). Cell division has a positive influence on the expression efficiency since, at the end of mitosis, pDNA or pDNA containing complexes near the chromatin are ...
De Smedt, Stefaan +5 more
core +1 more source
Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies. [PDF]
, 2008 Hepatitis C virus (HCV) infection is dependent on at least three coreceptors: CD81, scavenger receptor BI (SR-BI), and claudin-1. The mechanism of how these molecules coordinate HCV entry is unknown.
Balfe, Peter +6 more
core +3 more sources
Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding [PDF]
, 2016 The surface envelope glycoprotein (SU) of Human immunodeficiency virus type 1 (HIV-1), gp120SU plays an essential role in virus binding to target CD4+ T-cells and is a major vaccine target.
Bess, JW +15 more
core +1 more source