Results 171 to 180 of about 205,399 (342)

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

open access: yesAdvanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo   +5 more
wiley   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

open access: yesAdvanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen   +7 more
wiley   +1 more source

Characterization of the longitudinal HIV-1 quasispecies evolution in HIV-1 infected individuals co-infected with Mycobacterium tuberculosis [PDF]

open access: yes, 2010
One of the earliest and most striking observations made about HIV is the extensive genetic variation that the virus has within individual hosts, particularly in the hypervariable regions of the env gene which is divided into 5 variable regions (V1-V5 ...
Leulebirhan, Tsigereda Biru
core  

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

open access: yesAdvanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin   +15 more
wiley   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

open access: yesAdvanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah   +3 more
wiley   +1 more source

Assessing Angiogenic Properties In Vitro or In Ovo of Pre‐Crosslinked Alginate‐Dialdehyde‐Gelatin Hydrogels Incorporating Boron‐Doped Mesoporous Bioactive Glass Particles

open access: yesAdvanced NanoBiomed Research, EarlyView.
This study examines the influence of boron‐doped mesoporous bioactive glass nanoparticles (MBGN) blended in cast and 3D‐printed pre‐crosslinked alginate‐dialdehyde‐gelatin (ADA‐GEL). Addition of 0.5% and 1% MBGN did not negatively affect the viability of human umbilical vein endothelial cells (HUVECs), or the sprouting of HUVEC spheroids.
Rafael Schmid   +12 more
wiley   +1 more source

Integrated Evaluation of Contaminant Profiles, Detection Techniques, and Management Strategies for Tannery Sludge

open access: yesAsia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT This review article critically examines the environmental and health hazards of tannery sludge (TS), a complex by‐product of the leather tanning industry. TS is characterized by a diverse array of contaminants, including heavy metals like chromium, organic pollutants such as polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds ...
Yashar Aryanfar   +10 more
wiley   +1 more source

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