Results 131 to 140 of about 4,157,307 (334)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

The Comparative Full-Length Genome Characterization of African Swine Fever Virus Detected in Thailand

open access: yesAnimals
African swine fever virus (ASFV) has been responsible for the globally devastating epidemics in wild and domesticated pigs. Of the 24 identified ASFV genotypes, genotype II is the primary cause for the pandemic occurring in Europe and Asia since its ...
Muhammad Salman   +14 more
doaj   +1 more source

‘Viral’ hunts? A cultural Darwinian analysis of witch persecutions [PDF]

open access: yes, 2019
The theory of Darwinian cultural evolution is gaining currency in many parts of the socio-cultural sciences, but it remains contentious. Critics claim that the theory is either fundamentally mistaken or boils down to a fancy re-description of things we ...
Boudry, Maarten, Hofhuis, Steije
core   +1 more source

The role of viral evolution in rabies host shifts and emergence

open access: yesCurrent Opinion in Virology, 2014
Highlights • Rabies virus has a broad host range, but transmission cycles are species-specific.• Significant barriers limit viral establishment in new host species, but are poorly characterised.• Viral preadaptation may facilitate emergence, but does not
Nardus Mollentze, R. Biek, D. Streicker
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Endogenous caulimovirid sequences are widespread in plant genomes [PDF]

open access: yes, 2010
Endogenous sequences from members of the Caulimoviridae and Geminiviridae families have been identified in the genome of several plant species. They are thought to result from illegitimate recombination events and are generally replication-defective ...
Choisne, Nathalie   +6 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Evolution of the digital society reveals balance between viral and mass media influence

open access: yes, 2014
Online social networks (OSNs) enable researchers to study the social universe at a previously unattainable scale. The worldwide impact and the necessity to sustain their rapid growth emphasize the importance to unravel the laws governing their evolution.
Boguna, Marian, Kleineberg, Kaj-Kolja
core   +2 more sources

H3N2 influenza viruses in humans: Viral mechanisms, evolution, and evaluation

open access: yesHuman Vaccines & Immunotherapeutics, 2018
Annual seasonal influenza vaccines are composed of two influenza A strains representing the H1N1 and H3N2 subtypes, and two influenza B strains representing the Victoria and Yamagata lineages.
James D. Allen, T. Ross
semanticscholar   +1 more source

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