Results 121 to 130 of about 123,823 (255)

Proteomics Computational Analyses Suggest That the Envelope Glycoproteins of Segmented Flavi-Like Jingmen Group Viruses Are Class II Viral Fusion Proteins (β-Penetrenes) with Mucin-Like Domains

, 2020
Courtney E. Garry, Robert F. Garry
openalex   +2 more sources

Disruption of disulfides within RBD of SARS‐CoV‐2 spike protein prevents fusion and represents a target for viral entry inhibition by registered drugs [PDF]

, 2021
Mateja Manček‐Keber, Iva Hafner‐Bratkovič, Duško Lainšček, Mojca Benčina, Tea Govednik, Sara Orehek, Tjaša Plaper, Vid Jazbec, Valter Bergant, Vincent Grass, Andreas Pichlmair, Roman Jerala   +11 more
openalex   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

ACE2-Fc fusion protein overcomes viral escape by potently neutralizing SARS-CoV-2 variants of concern

, 2022
Tsung-I Tsai, Jahan S. Khalili, Mark Gilchrist, Andrew B. Waight, Daniella Cohen, Zhuo Shi, Yong Zhang, Muran Ding, Hai Zhu, Amanda Nga-Sze Mak, Yi Zhu, Dennis R. Goulet   +11 more
openalex   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing, membrane fusion, and viral infectivity [PDF]

, 2020
Xiaoyi Jiang, Zhengrong Zhang, Chenxi Wang, Hongguang Ren, Lihua Gao, Haoran Peng, Zubiao Niu, He Ren, Hongyan Huang, Qiang Sun   +9 more
openalex   +1 more source

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

Advanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans, Anna P. Constantinou, Matthew J. Kibble, Valeria Nele, Daniel Reumann, Luca Bau, Sebastien J. P. Callens, James P. K. Armstrong, Nicolas Newell, Constantin C. Coussios, Molly M. Stevens, Michael D. Gray   +11 more
wiley   +1 more source

Rescuing Newcastle disease virus with tag for screening viral-host interacting proteins based on highly efficient reverse genetics

Frontiers in Veterinary Science
The interaction between viral proteins and host proteins plays a crucial role in the process of virus infecting cells. Tags such as HA, His, and Flag do not interfere with the function of fusion proteins and are commonly used to study protein–protein ...
Ruiwei Wang, Xuhong Cao, Kejia Lu, Zhengwu Chang, Xiaoyu Dong, Hanwei Guo, Xi Wei, Ruyi Dang, Juan Wang, Xinglong Wang, Sa Xiao, Haijin Liu, Zengqi Yang   +12 more
doaj   +1 more source

3D Printing of Bacteriophage‐Loaded Hydrogels: Development of a Local and Long‐Lasting Delivery System

Advanced Healthcare Materials, EarlyView.
This research investigates the feasibility of 3D‐printing of a bacteriophage‐containing hydrogel made of alginate and methylcellulose. The printed hydrogels steadily release active bacteriophages for up to 35 days which is beneficial to treat implant‐associated infections.
Corina Vater, Gopala Krishna Mannala, Max von Witzleben, Richard Frank Richter, Nike Walter, Michael Gelinsky, Volker Alt, Anja Lode, Markus Rupp   +8 more
wiley   +1 more source