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Viral Membrane Fusion: A Dance Between Proteins and Lipids
Annual Review of Virology, 2023 There are at least 21 families of enveloped viruses that infect mammals, and many contain members of high concern for global human health. All enveloped viruses have a dedicated fusion protein or fusion complex that enacts the critical genome-releasing membrane fusion event that is essential before viral replication within the host cell interior can ...
Judith M White +2 more
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Viral fusion proteins: multiple regions contribute to membrane fusion
Biochimica Et Biophysica Acta - Biomembranes, 2003 In recent years, the simple picture of a viral fusion protein interacting with the cell and/or viral membranes by means of only two localized segments (i.e. the fusion peptide and the transmembrane domain) has given way to a more complex picture in which multiple regions from the viral proteins interact with membranes.
Yechiel Shai
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Membrane rearrangements in fusion mediated by viral proteins
Trends in Microbiology, 1997Diverse enveloped viruses enter host cells by fusing their envelopes with cell membranes. The mechanisms of merger of lipid bilayers of two membranes mediated by influenza hemagglutinin and other viral fusion proteins apparently involve local lipidic connections that evolve into a bilayer septum in which a pore forms and expands.
G B, Melikyan, L V, Chernomordik
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Histidine protonation and the activation of viral fusion proteins
Biochemical Society Transactions, 2008Many viral fusion proteins only become activated under mildly acidic condition (pH 4.5–6.5) close to the pKa of histidine side-chain protonation. Analysis of the sequences and structures of influenza HA (haemagglutinin) and flaviviral envelope glycoproteins has led to the identification of a number of histidine residues that are not only fully ...
Mueller, D. +5 more
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Properties of a Viral Fusion Protein
1988The mechanisms by which proteins mediate biological membrane fusion are not clearly understood. We have analyzed acid-induced changes in influenza hemagglutinin (HA), a viral membrane fusion factor, and correlated them with its acid-triggered fusion activity.
Robert W. Doms, Ari Helenius
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Fusion inhibition: Bioassay of a Type C viral protein
Virology, 1975Abstract Based on the observation that concentrated RD-114 virus directly induces fusion in a Rous sarcoma virus-transformed human glioma cell line, KC, an RD-114 virus protein was identified which had the property of inhibiting this fusion. The protein was irreversibly denatured by 2-mercaptoethanol, reacted with neutralizing sera to RD-114 virus ...
K, Rand +4 more
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Peripherin-2: An Intracellular Analogy to Viral Fusion Proteins
Biochemistry, 2007The C-terminus of the intracellular retinal rod outer segment disk protein peripherin-2 binds to membranes, adopts a helical conformation, and promotes membrane fusion, which suggests an analogy to the structure and function of viral envelope fusion proteins. Nuclear magnetic resonance (NMR) data and fluorescence data show that a 63-residue polypeptide
T C, Edrington +4 more
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Viral proteins in cell fusion.
The Tokai journal of experimental and clinical medicine, 1983F (fusion) and HANA (hemagglutinin and neuraminidase) glycoproteins of HVJ (Sendai virus) were purified and characterized. The NH2-terminal hydrophobic region of the F1 (larger) subunit of F (fusion)-glycoprotein seems to be required for the hemolytic and cell fusion-inducing activity of the virus for the following reasons.
A, Asano, K, Asano
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