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Pore Formation in Target Liposomes by Viral Fusion Proteins
2003Publisher Summary This chapter introduces methodologies to characterize plasma-membrane and viral-membrane interactions in a model system using liposomes as target membranes. It focuses on hemagglutinin (HA), a trimeric integral membrane protein that protrudes from the viral membrane as a spike, with a long stem and a globular tip.
Pierre, Bonnafous, Toon, Stegmann
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Patch clamp studies of single cell-fusion events mediated by a viral fusion protein
Nature, 1989To enter cells, viruses must fuse their envelope with a host cell membrane. Fusion is mediated by specific, membrane-spanning fusion proteins, of which the influenza virus haemagglutinins (HA) are the best characterized. Several HAs have been sequenced, and the crystal structure of the major part of one HA is known.
A E, Spruce +3 more
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Peptide models for the membrane destabilizing actions of viral fusion proteins
Biopolymers, 1992AbstractThe fusion of enveloped viruses to target membranes is promoted by certain viral fusion proteins. However, many other proteins and peptides stabilize bilayer membranes and inhibit membrane fusion. We have evaluated some characteristics of the interaction of peptides that are models of segments of measles and influenza fusion proteins with ...
R M, Epand +6 more
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Mechanism and energetics of lipid recognition by viral fusion proteins
2023During viral infection, viral fusion proteins bind to the host cell membrane prior to catalyzing the fusion of the viral envelope with the host membrane. The atomic architectures of fusion proteins and their interactions with membrane receptors have been revealed by numerous structural studies, however, the interactions of fusion proteins with the host
Poojari, Chetan +2 more
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Targeting the Hendra Virus Fusion Protein Transmembrane Domain to Inhibit Viral Fusion
The FASEB Journal, 2017Hendra Virus is a zoonotic virus in the family Paramyxoviridae. It is an enveloped, negative sense single stranded RNA virus that is highly pathogenic, but currently there is no approved antiviral therapeutic or vaccine. Further elucidation of the mechanisms that underlie viral entry into a cell will assist in presenting additional targets for ...
Chelsea Barrett +2 more
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Virology, 1983
The characteristics of fusion of the membrane of Sendai virus with that of liposomes has been investigated using two different methods to monitor the fusion reaction. The first method, which permits quantitation of lipid fused with virus, depends on separation by centrifugation of unfused liposomes from those fused with virus.
M C, Hsu, A, Scheid, P W, Choppin
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The characteristics of fusion of the membrane of Sendai virus with that of liposomes has been investigated using two different methods to monitor the fusion reaction. The first method, which permits quantitation of lipid fused with virus, depends on separation by centrifugation of unfused liposomes from those fused with virus.
M C, Hsu, A, Scheid, P W, Choppin
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Viral Fusion Protein TM-TM Interactions
2017Enveloped viruses, such as HIV, influenza, and Ebola, utilize surface glycoproteins to bind and fuse with a target cell membrane. This fusion event is necessary for release of viral genomic material so the virus can ultimately reproduce and spread.
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Structural comparison of three viral “fusion” proteins
Biochemical Society Transactions, 1991B H, Nicholson, M, Naase
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Viral and Cellular Membrane Fusion Proteins
Annual Review of Physiology, 1990openaire +2 more sources
Probing the Function of Viral Fusion Proteins with Synthetic Peptides
1987Synthetic peptides offer several unique approaches to studying molecular and cellular interactions. Not only do these peptides provide A. large quantity of material for experimental analysis, but they also offer A. degree of homogeneity that is difficult to obtain through routine biochemical purification.
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