Results 1 to 10 of about 623,045 (205)

The Vaginal Microbiome of Nonhuman Primates Can Be Only Transiently Altered to Become Lactobacillus Dominant without Reducing Inflammation

Microbiology Spectrum, 2021
The vaginal microbiome composition in humans is categorized based upon the degree to which one of four species of Lactobacillus is dominant (Lactobacillus crispatus, community state type I [CST I], Lactobacillus gasseri, CST II, Lactobacillus iners, CST ...
Charlotte A. Langner, Alexandra M. Ortiz, Jacob K. Flynn, Heather Kendall, Laurel A. Lagenaur, Jason M. Brenchley   +5 more
doaj   +1 more source

Host Genetics and Environment Shape the Composition of the Gastrointestinal Microbiome in Nonhuman Primates

Microbiology Spectrum, 2023
The bacterial component of the gastrointestinal tract microbiome is comprised of hundreds of species, the majority of which live in symbiosis with the host.
Jacob K. Flynn, Alexandra M. Ortiz, Richard Herbert, Jason M. Brenchley   +3 more
doaj   +1 more source

IL-7-Adjuvanted Vaginal Vaccine Elicits Strong Mucosal Immune Responses in Non-Human Primates

Frontiers in Immunology, 2021
Mucosal immune responses are crucial in protecting against pathogens entering through mucosal surfaces. However, due to poor T-cell responsiveness upon mucosal antigenic stimulation, mucosal immunity remains difficult to obtain through vaccines and ...
Sandrine Logerot, Suzanne Figueiredo-Morgado, Bénédicte Charmeteau-de-Muylder, Abdelkader Sandouk, Anne-Sophie Drillet-Dangeard, Morgane Bomsel, Isabelle Bourgault-Villada, Anne Couëdel-Courteille, Rémi Cheynier, Magali Rancez   +9 more
doaj   +1 more source

Protocol for analyzing and visualizing antiviral immune responses after acute infection of the murine oral mucosa

STAR Protocols, 2021
Summary: The oral mucosa is an important site for virus infection and transmission, yet few animal models exist to examine the virology, pathology, and immunology of acute oral mucosal viral infection.
John P. Shannon, Christian R. Cherry, Sophia M. Vrba, Heather D. Hickman   +3 more
doaj   +1 more source

Butyrate administration is not sufficient to improve immune reconstitution in antiretroviral-treated SIV-infected macaques

Scientific Reports, 2022
Defective gastrointestinal barrier function and, in turn, microbial translocation have been identified as significant contributors to persistent inflammation in antiretroviral (ARV)-treated people living with HIV. Metabolic supplementation of short-chain
Alexandra M. Ortiz, Jennifer Simpson, Charlotte A. Langner, Phillip J. Baker, Cynthia Aguilar, Kelsie Brooks, Jacob K. Flynn, Carol L. Vinton, Andrew R. Rahmberg, Heather D. Hickman, Jason M. Brenchley   +10 more
doaj   +1 more source

Experimental bacterial dysbiosis with consequent immune alterations increase intrarectal SIV acquisition susceptibility

Cell Reports, 2023
Summary: Variations in the composition of the intestinal bacterial microbiome correlate with acquisition of some sexually transmitted pathogens. To experimentally assess the contribution of intestinal dysbiosis to rectal lentiviral acquisition, we induce
Alexandra M. Ortiz, Phillip J. Baker, Charlotte A. Langner, Jennifer Simpson, Apollo Stacy, Jacob K. Flynn, Carly E. Starke, Carol L. Vinton, Christine M. Fennessey, Yasmine Belkaid, Brandon F. Keele, Jason M. Brenchley   +11 more
doaj   +1 more source

Biomarkers of Cellular Stress Do Not Associate with sCD14 in Progressive HIV and SIV Infections in Vivo

Pathogens and Immunity, 2020
Background: Microbial translocation occurs after damage to the structural and/or immunological barrier of the gastrointestinal (GI) tract into circulation.
Carol L. Vinton, Carly E. Starke, Alexandra M. Ortiz, Stephen H. Lai, Jacob K. Flynn, Ornella Sortino, Kenneth Knox, Irini Sereti, Jason Brenchley   +8 more
doaj   +1 more source

Are Reduced Levels of Coagulation Proteins Upon Admission Linked to COVID-19 Severity and Mortality?

Frontiers in Medicine, 2021
Background: The link between coagulation system disorders and COVID-19 has not yet been fully elucidated.Aim: Evaluating the association of non-previously reported coagulation proteins with COVID-19 severity and mortality.Design: Cross-sectional study of
Francisco C. Ceballos, Pablo Ryan, Rafael Blancas, María Martin-Vicente, Erick Joan Vidal-Alcántara, Felipe Peréz-García, Sofía Bartolomé, Juan Churruca-Sarasqueta, Ana Virseda-Berdices, Oscar Martínez-González, Oscar Brochado-Kith, Marta Rava, Carolina Vilches-Medkouri, Natalia Blanca-López, Ignacio Ramirez Martinez-Acitores, Patricia Moreira-Escriche, Carmen De Juan, Salvador Resino, Amanda Fernández-Rodríguez, María Ángeles Jiménez-Sousa   +19 more
doaj   +1 more source

Zika virus spreads through infection of lymph node-resident macrophages

Cell Reports, 2023
Summary: To disseminate through the body, Zika virus (ZIKV) is thought to exploit the mobility of myeloid cells, in particular monocytes and dendritic cells.
Glennys V. Reynoso, David N. Gordon, Anurag Kalia, Cynthia C. Aguilar, Courtney S. Malo, Maya Aleshnick, Kimberly A. Dowd, Christian R. Cherry, John P. Shannon, Sophia M. Vrba, Autumn C. Holmes, Yael Alippe, Sonia Maciejewski, Kenichi Asano, Michael S. Diamond, Theodore C. Pierson, Heather D. Hickman   +16 more
doaj   +1 more source

Widespread and dynamic expression of granzyme C by skin-resident antiviral T cells

Frontiers in Immunology, 2023
After recognition of cognate antigen (Ag), effector CD8+ T cells secrete serine proteases called granzymes in conjunction with perforin, allowing granzymes to enter and kill target cells.
Ramon A. Lujan, Ramon A. Lujan, Luxin Pei, John P. Shannon, Nathânia Dábilla, Patrick T. Dolan, Heather D. Hickman   +6 more
doaj   +1 more source