Results 91 to 100 of about 1,223,168 (317)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Functional Analyses of Bovine Foamy Virus-Encoded miRNAs Reveal the Importance of a Defined miRNA for Virus Replication and Host–Virus Interaction

Viruses, 2020
In addition to regulatory or accessory proteins, some complex retroviruses gain a repertoire of micro-RNAs (miRNAs) to regulate and control virus–host interactions for efficient replication and spread.
Wenhu Cao, Erik Stricker, Agnes Hotz-Wagenblatt, Anke Heit-Mondrzyk, Georgios Pougialis, Annette Hugo, Jacek Kuźmak, Magdalena Materniak-Kornas, Martin Löchelt   +8 more
doaj   +1 more source

Antibodies Are Not Essential for the Resolution of Primary Cytomegalovirus Infection but Limit Dissemination of Recurrent Virus [PDF]

, 1994
Virus shedding from the epithelial cells of the serous acini of salivary glands is a major source for the horizontal transmission of cytomegalovirus. These cells are, different to other tissues, exempt from CD8 T lymphocyte control. CD4 T lymphocytes are
Crnkovic, Irena, Koszinowski, Ulrich H., Koszinovski, UH, I Crnković, U H Koszinowski, Pavic, Ivica, S Jonjić, Lucin, Pero, I Pavić, B Polić, P Lucin, Polic, Bojan, Jonjic, Stipan   +12 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Interferons in Viral Infections

Viruses
Interferons (IFNs) are cytokines that inhibit viral replication in host cells by triggering innate immune responses through the transcriptional induction of various IFN-stimulated genes (ISGs) [...]
Pracheta Sengupta, Saurabh Chattopadhyay
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection

, 2001
Cytotoxic T lymphocytes (CTLs) play a vital part in controlling viral replication during human viral infections. Most studies in human infections have focused on CTL specificities in chronic infection and few data exist regarding the specificity of the ...
Sekaly, R.P., Eldridge, RL, Kalams, SA, Altfeld, M.A., He, S, Phillips, M.N., He, S., Phillips, MN, Tang, Y, Eldridge, R.L., Walker, B.D., Nguyen, T, Addo, MM, Muckerjee, J.S., Rosenberg, ES, Walker, BD, Nguyen, T.T., Bunce, M, Addo, M.M., Kalams, S.A., Mukherjee, JS, Rosenberg, E.S., Brander, C, Goulder, P.J.R., Brander, C., Goulder, PJ, Altfeld, MA, Sekaly, RP, Tang, Y., Bunce, M.   +29 more
core   +1 more source

Selective expansion of viral variants following experimental transmission of a reconstituted feline immunodeficiency virus quasispecies [PDF]

, 2013
Following long-term infection with virus derived from the pathogenic GL8 molecular clone of feline immunodeficiency virus (FIV), a range of viral variants emerged with distinct modes of interaction with the viral receptors CD134 and CXCR4, and ...
Margaret J Hosie, Martin Kraase (276419), McMonagle Elizabeth, Kraase, M., Varela, M., Mariana Varela (81646), Kraase Martin, Nicola Logan (276420), Mariana Varela, Hosie Margaret J., Brian J Willett, Brian J. Willett (276418), Logan Nicola, Elizabeth McMonagle (276421), Willett Brian J., Hosie, M.J., Varela Mariana, Nicola Logan, Logan, N., Willett, B.J., McMonagle, E., Margaret J. Hosie (276422), Elizabeth McMonagle, Martin Kraase   +23 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Association of early age at establishment of chronic hepatitis B infection with persistent viral replication, liver cirrhosis and hepatocellular carcinoma: a systematic review. [PDF]

, 2013
Age at infection with hepatitis B virus (HBV) is a known risk factor for chronic HBV infection. However, in addition, there is some evidence that early age at infection further increases the risk of primary liver cancer beyond its association with ...
Bottomley, Christian, Andrew J Hall, Hong-Jing Yan, Tsuchiya Naho, Hall, Andrew, Andrew J. Hall (78002), Shimakawa Yusuke, Yan, Hong-Jing, Yusuke Shimakawa, Christian Bottomley, Hall Andrew J., Hall, Andrew J, Yan Hong-Jing, Shimakawa, Yusuke, Tsuchiya, Naho, Naho Tsuchiya, Bottomley Christian, Andrew J. Hall, Yusuke Shimakawa (435296), Hong-Jing Yan (435297), Naho Tsuchiya (211103), Christian Bottomley (144483)   +21 more
core   +1 more source