Results 71 to 80 of about 1,223,168 (317)

Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease

, 2012
Hepatitis B virus (HBV)-specific T-cell responses are important in the natural history of HBV infection. The number of known HBV-specific T-cell epitopes is limited, and it is not clear whether viral evolution occurs in chronic HBV infection. We aimed to
Chopra, A., Gordon, A, Scott Bowden, Pfafferott, K, Desmond, P.V., Ian R. James, Revill, P.A., Chopra, A, Mallal, SA, Silvana Gaudieri, Anna Ayres, Lewin, S.R., Thompson, AJ, Desmond, C.P., Jennifer Audsley, James, IR, Locarnini, SA, Stephen A. Locarnini, Sharon R. Lewin, James, I.R., Locarnini, S.A., Chivers, S., Christopher P. Desmond, Desmond, PV, Thompson, A.J., Stuart K. Roberts, Audsley, J, Revill, PA, Lau, GK, Gaudieri, S, Gaudieri, S., Audsley, J., Day, C, Caroline Day, Ayres, A, Day, C., Paul V. Desmond, Pfafferott, K., Gordon, A., Roberts, SK, Peter A. Revill, Alexander J. Thompson, Ayres, A., Desmond, CP, Sarah Chivers, Katja Pfafferott, Bowden, S., George K. Lau, Simon A. Mallal, Lewinb, SR, Lau, G.K., Roberts, S. K., Abha Chopra, Bowden, S, Mallal, S.A., Adam Gordon, Chivers, S   +56 more
core   +1 more source

Dengue viral infections [PDF]

Postgraduate Medical Journal, 2004
Abstract Dengue viral infections are one of the most important mosquito borne diseases in the world. They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue haemorrhagic fever (DHF), or dengue shock syndrome.
G N, Malavige, S, Fernando, D J, Fernando, S L, Seneviratne   +3 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA+ B cells

Molecular Cancer
Background Dysregulation of immune surveillance is tightly linked to the development of metabolic dysfunction-associated steatohepatitis (MASH)-driven hepatocellular carcinoma (HCC); however, its underlying mechanisms remain unclear.
Ying Xie, Yu Huang, Zhi-Yong Li, Weihua Jiang, Nan-Xi Shi, Yuanzhi Lu, Guangchao Cao, Zhinan Yin, Xue-Jia Lin   +8 more
doaj   +1 more source

Adherence in chronic hepatitis B: associations between medication possession ratio and adverse viral outcomes

BMC Gastroenterology, 2020
Background Antiviral therapy for chronic hepatitis B (CHB) is effective and can substantially reduce the risk of progressive liver disease and hepatocellular carcinoma but is often administered for an indefinite duration.
Nicole L. Allard, Jennifer H. MacLachlan, Anouk Dev, James Dwyer, Geeta Srivatsa, Timothy Spelman, Alexander J. Thompson, Benjamin C. Cowie   +7 more
doaj   +1 more source

Defense pathways in Arabidopsis restricting compatible tobamoviruses during infection [PDF]

, 2014
Virus infected plants often develop strong disease symptoms including leaf deformation, chlorosis, necrosis and growth inhibition. In agriculture systems virus infection can lead to severe yield losses and a better understanding of plant defenses against
Kørner, Camilla Julie
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Review of Receptor Recognition Mechanisms in Coronaviruses

Viruses
Cellular receptor recognition exerts fundamental roles during coronavirus infection. Clarifying the regulatory mechanism of virus receptor helps to better understand viral infection, transmission and pathogenesis; predict potential host and how viral ...
Jie Liu, Wenjing Luo, Jianming Li, Bingyi Cai, Zhiwei Lei, Shiyun Lin, Zhuohong Chen, Zhaoyang Yue, Xulin Chen, Yongkui Li, Zhen Luo, Qiwei Zhang, Xin Chen   +12 more
doaj   +1 more source

Acute Simian Immunodeficiency Virus Infection Triggers Early and Transient Interleukin-7 Production in the Gut, Leading to Enhanced Local Chemokine Expression and Intestinal Immune Cell Homing

Frontiers in Immunology, 2017
The intestinal barrier, one of the first targets of HIV/simian immunodeficiency virus (SIV) is subjected to major physiological changes during acute infection.
Rosalie Ponte, Rosalie Ponte, Rosalie Ponte, Magali Rancez, Magali Rancez, Magali Rancez, Suzanne Figueiredo-Morgado, Suzanne Figueiredo-Morgado, Suzanne Figueiredo-Morgado, Jacques Dutrieux, Jacques Dutrieux, Jacques Dutrieux, Véronique Fabre-Mersseman, Véronique Fabre-Mersseman, Véronique Fabre-Mersseman, Bénédicte Charmeteau-de-Muylder, Bénédicte Charmeteau-de-Muylder, Bénédicte Charmeteau-de-Muylder, Thomas Guilbert, Thomas Guilbert, Thomas Guilbert, Jean-Pierre Routy, Rémi Cheynier, Rémi Cheynier, Rémi Cheynier, Anne Couëdel-Courteille, Anne Couëdel-Courteille, Anne Couëdel-Courteille, Anne Couëdel-Courteille   +28 more
doaj   +1 more source