Results 71 to 80 of about 3,007,842 (264)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo. [PDF]

, 2012
Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the ...
Lisnić, V. (V) J. (J), Marcinowski, Lisa, Tanguy, M. (M), Ruzsics, Zsolt, Tanguy Mélanie, Ralf Zimmer, Jonjic, S. (S), Erhard, F. (F), Krmpotic Astrid, Marina Babic (184917), Corinna Benkartek, Bernd Rädle (138968), Zsolt Ruzsics, Babic, Marina, Ruzsics, Z. (Zsolt), Jonjic Stipan, Trgovcich, Joanne, Erhard, Florian, Chane-woon-ming, B. (Béatrice), Tanguy, Mélanie, Chane-Woon-Ming Béatrice, Koszinowski, U. (Ulrich H), Marcinowski Lisa, Marina Babic, Ulrich H Koszinowski, Koszinowski Ulrich H., Joanne Trgovcich (184921), Astrid Krmpotic (184892), Stipan Jonjic (139671), Stipan Jonjic, Babic Marina, Vanda J. Lisnić (184897), Krmpotic, A. (A), Sébastien Pfeffer, Benkartek Corinna, Zsolt Ruzsics (75383), Béatrice Chane-Woon-Ming (184904), Zimmer Ralf, Lisa Marcinowski (138962), Marcinowski, L. (L), Marcinowski, L. (Lisa), Krmpotic, Astrid, Dölken, Lars, Béatrice Chane-Woon-Ming, Joanne Trgovcich, Rädle Bernd, Trgovcich, J. (Joanne), Rädle, B. (Bernd), Lars Dölken, Astrid Krmpotic, Florian Erhard (184910), Lars Dölken (138985), Babic, M. (M), Jonjic, S. (Stipan), Ulrich H. Koszinowski (152143), Lisnić, Vanda J., Lisnić, V. (Vanda J), Trgovcich Joanne, Benkartek, Corinna, Zimmer, Ralf, Erhard Florian, Dölken Lars, Ruzsics, Z. (Z), Ralf Zimmer (21157), Rädle, B. (B), Dölken, L. (L), Vanda J Lisnić, Tuddenham, L. (Lee), Trgovcich, J. (J), Lisnić Vanda J., Lee Tuddenham (141455), Pfeffer, S. (Sebastien), Rädle, Bernd, Corinna Benkartek (184913), Lisa Marcinowski, Zimmer, R. (Ralf), Tuddenham Lee, Benkartek, C. (C), Lee Tuddenham, Erhard, F. (Florian), Pfeffer Sébastien, Babic, M. (Marina), Tuddenham, Lee, Mélanie Tanguy (4691986), Mélanie Tanguy, Florian Erhard, Koszinowski, U. (U) H. (H), Ruzsics Zsolt, Krmpotic, A. (Astrid), Koszinowski, Ulrich H., Tanguy, M. (Mélanie), Dölken, L. (Lars), Zimmer, R. (R), Chane-Woon-Ming, Béatrice, Bernd Rädle, Sébastien Pfeffer (8264), Pfeffer, Sébastien, Benkartek, C. (Corinna), Jonjic, Stipan   +98 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers [PDF]

, 2009
Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are believed to play a crucial role in viral containment ...
C. J. Brumme, F. Pereyra, Harrigan, P. R., Brumme, Z. L., John, M., B. D. Walker, Brockman, M. A., P. R. Harrigan, T. Miura, Miura, T., Block, B. L., Trocha, A., M. A. Brockman, M. John, A. Trocha, Z. L. Brumme, S. Mallal, Pereyra, F., Walker, B. D., B. L. Block, Brumme, C. J., Mallal, S.   +21 more
core   +1 more source

Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness [PDF]

, 2014
Includes bibliographical references.HIV-1 antibody dependent cell cytotoxicity (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination.
Bandawe, Gama Petulo
core   +1 more source

IFNL4-rs12979860 CC genotype predisposes to accelerated terminal exhaustion and senescence in HIV/HCV-chronic infection

Journal of Translational Medicine
Purpose rs12979860 polymorphism of the lambda 4 interferon (IFNL4) gene has been related with Hepatitis C Virus (HCV) spontaneous clearance (CC genotype favourable versus CT/TT). The implications of this polymorphism over chronic-HCV disease are unknown,
Sonia Arca-Lafuente, Violeta Lara-Aguilar, Manuel Llamas-Adán, Sergio Grande-García, Andrés Deza de la Casa, Luz Martín-Carbonero, Pablo Ryan, Ignacio de los Santos, Mariano Matarranz, Mª Ángeles Jiménez-Sousa, Amanda Fernández-Rodríguez, Verónica Briz   +11 more
doaj   +1 more source

Acute Simian Immunodeficiency Virus Infection Triggers Early and Transient Interleukin-7 Production in the Gut, Leading to Enhanced Local Chemokine Expression and Intestinal Immune Cell Homing

Frontiers in Immunology, 2017
The intestinal barrier, one of the first targets of HIV/simian immunodeficiency virus (SIV) is subjected to major physiological changes during acute infection.
Rosalie Ponte, Rosalie Ponte, Rosalie Ponte, Magali Rancez, Magali Rancez, Magali Rancez, Suzanne Figueiredo-Morgado, Suzanne Figueiredo-Morgado, Suzanne Figueiredo-Morgado, Jacques Dutrieux, Jacques Dutrieux, Jacques Dutrieux, Véronique Fabre-Mersseman, Véronique Fabre-Mersseman, Véronique Fabre-Mersseman, Bénédicte Charmeteau-de-Muylder, Bénédicte Charmeteau-de-Muylder, Bénédicte Charmeteau-de-Muylder, Thomas Guilbert, Thomas Guilbert, Thomas Guilbert, Jean-Pierre Routy, Rémi Cheynier, Rémi Cheynier, Rémi Cheynier, Anne Couëdel-Courteille, Anne Couëdel-Courteille, Anne Couëdel-Courteille, Anne Couëdel-Courteille   +28 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Effect of the initial dose of foot-and-mouth disease virus on the early viral dynamics within pigs [PDF]

, 2009
This paper investigates the early viral dynamics of foot-and-mouth disease (FMD) within infected pigs. Using an existing within-host model, we investigate whether individual variation can be explained by the effect of the initial dose of FMD virus. To do
Nicholas J. Savill, Alexandersen, Soren, Quan, Melvyn, Quan, M., Melvyn Quan, Louise Matthews, Howey, R., Matthews, L., Savill, Nicholas J., Matthews, Louise, Savill, N.J., Howey, Richard, Mark Woolhouse, Woolhouse, Mark; id_orcid, Søren Alexandersen, Woolhouse, M., Alexandersen, S., Richard Howey   +17 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source