Results 61 to 70 of about 1,648,672 (312)

Recycling Endosomes and Viral Infection

Viruses, 2016
Many viruses exploit specific arms of the endomembrane system. The unique composition of each arm prompts the development of remarkably specific interactions between viruses and sub-organelles. This review focuses on the viral–host interactions occurring
Sílvia Vale-Costa, Maria João Amorim
doaj   +1 more source

Zika virus infection in semen: Effect on human reproduction [PDF]

, 2017
Unique among vector-borne flaviviruses, Zika virus can infect testis and male genital tract, can persist in semen for months after symptoms onset, and be sexually transmitted.
Barzon, Luisa, Lavezzo, Enrico, Pal\ue3\ub9, Giorgio   +2 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Exosome Biogenesis, Regulation, and Function in Viral Infection

Viruses, 2015
Exosomes are extracellular vesicles released upon fusion of multivesicular bodies(MVBs) with the cellular plasma membrane. They originate as intraluminal vesicles (ILVs) duringthe process of MVB formation.
Marta Alenquer, Maria João Amorim
doaj   +1 more source

Clinical and Epidemiological Features of Actual Tick-Borne Infections under Conditions of Mass Vaccination against Tick-Borne Viral Encephalitis (by the Example of a Megapolis)

Эпидемиология и вакцинопрофилактика, 2023
Relevance. The clinical aspects of tick­borne viral encephalitis (TBE) and Lyme borrelliosis (LB) as monoinfections are well known. At the same time, the issues of interaction of pathogens in tick­borne encephalitis – Lyme borrelliosis mixed infection ...
V. A. Mishchenko, I. V. Vyalykh, A. G. Sergeev, I. P. Bykov, M. G. Toporkova, V. I. Chalapa   +5 more
doaj   +1 more source

The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses [PDF]

, 2016
Host cells respond to viral infections by producing type I interferon (IFN), which induces the expression of hundreds of interferon-stimulated genes (ISGs).
Diamond, Michael S, Farzan, Michael, Gorman, Matthew J, Hyde, Jennifer L, Poddar, Subhajit   +4 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

What role for cellular metabolism in the control of hepatitis viruses?

Frontiers in Immunology, 2022
Hepatitis B, C and D viruses (HBV, HCV, HDV, respectively) specifically infect human hepatocytes and often establish chronic viral infections of the liver, thus escaping antiviral immunity for years.
Olivier Diaz, Pierre-Olivier Vidalain, Christophe Ramière, Christophe Ramière, Vincent Lotteau, Laure Perrin-Cocon   +5 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Adherence in chronic hepatitis B: associations between medication possession ratio and adverse viral outcomes

BMC Gastroenterology, 2020
Background Antiviral therapy for chronic hepatitis B (CHB) is effective and can substantially reduce the risk of progressive liver disease and hepatocellular carcinoma but is often administered for an indefinite duration.
Nicole L. Allard, Jennifer H. MacLachlan, Anouk Dev, James Dwyer, Geeta Srivatsa, Timothy Spelman, Alexander J. Thompson, Benjamin C. Cowie   +7 more
doaj   +1 more source