Results 21 to 30 of about 254,896 (222)

Structural Motifs and Spatial Structures of Helicase (NS3) and RNA-dependent RNA-polymerase (NS5) of a Flavi-like Kindia tick virus (unclassified Flaviviridae)

Вопросы вирусологии, 2023
Introduction. Kindia tick virus (KITV) is a novel segmented unclassified flavi-like virus of the Flaviviridae family. This virus is associated with ixodes ticks and is potentially pathogenic to humans.
A. A. Gladysheva, A. V. Gladysheva, V. A. Ternovoi, V. B. Loktev   +3 more
doaj   +1 more source

Human Respiratory Syncytial Virus NS2 Protein Induces Autophagy by Modulating Beclin1 Protein Stabilization and ISGylation

mBio, 2022
Paramyxoviruses such as respiratory syncytial virus (RSV) are the leading cause of pneumonia in infants, the elderly, and immunocompromised individuals.
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose   +8 more
doaj   +1 more source

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

A Viral Nonstructural Protein Regulates Bluetongue Virus Trafficking and Release [PDF]

Journal of Virology, 2009
ABSTRACT Bluetongue virus (BTV), a nonenveloped insect-borne virus, is released from infected cells by multiple pathways. Unlike other nonenveloped viruses, in addition to cell lysis the newly synthesized virus particles also appear to use a unique “budding” process.
Cristina C P, Celma, Polly, Roy
openaire   +2 more sources

The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts [PDF]

Nucleic Acids Research, 2018
AbstractNumerous mammalian proto-oncogene and other growth-regulatory transcripts are upregulated in malignancy due to abnormal mRNA stabilization. In hepatoma cells expressing a hepatitis C virus (HCV) subgenomic replicon, we found that the viral nonstructural protein 5A (NS5A), a protein known to bind to viral RNA, also bound specifically to human ...
Guo, Liang, Sharma, Suresh D, Debes, Jose D, Beisang, Daniel, Rattenbacher, Bernd, Louis, Irina Vlasova-St, Wiesner, Darin L, Cameron, Craig E, Bohjanen, Paul R   +8 more
openaire   +5 more sources

Specific Interaction between Human Parechovirus Nonstructural 2A Protein and Viral RNA [PDF]

Journal of Biological Chemistry, 2004
The functional properties of the nonstructural 2A protein are variable among different picornaviruses. The 2A protein of the human parechovirus 1 (HPEV1) has been shown to lack the proteolytic activity found in many other picornaviruses, but no particular function has been identified for HPEV1 2A. To obtain information about the role of HPEV1 2A in the
Olga, Samuilova, Camilla, Krogerus, Tuija, Pöyry, Timo, Hyypiä   +3 more
openaire   +2 more sources

Experimental Dengue Virus Type 4 Infection Increases the Expression of MicroRNAs-15/16, Triggering a Caspase-Induced Apoptosis Pathway

Current Issues in Molecular Biology, 2023
The World Health Organization has estimated the annual occurrence of approximately 392 million dengue virus (DENV) infections in more than 100 countries where the virus is endemic, which represents a serious threat to humanity.
Samir Mansour Moraes Casseb, Karla Fabiane Lopes de Melo, Carlos Alberto Marques de Carvalho, Carolina Ramos dos Santos, Edna Cristina Santos Franco, Pedro Fernando da Costa Vasconcelos   +5 more
doaj   +1 more source

Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures

Journal of Biological Chemistry, 2022
Hepatitis C virus (HCV) is a major cause of liver-related diseases and hepatocellular carcinoma. The helicase domain of one of the nonstructural proteins of HCV, NS3 (nonstructural protein 3), is essential for viral replication; however, its specific biological role is still under investigation.
Belachew, Binyam, Gao, Jun, Byrd, Alicia K., Raney, Kevin D.   +3 more
openaire   +2 more sources

Nonstructural proteins 2B and 4A of Tembusu virus induce complete autophagy to promote viral multiplication in vitro

Veterinary Research, 2023
Tembusu virus (TMUV) is an emerging flavivirus that has broken out in different regions of China. TMUV infection has been reported to induce autophagy in duck embryo fibroblast cells.
Wangyang Tan, Senzhao Zhang, Yu He, Zhen Wu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Bin Tian, Shun Chen, Anchun Cheng   +19 more
doaj   +1 more source

Mutagenesis Mapping of RNA Structures within the Foot-and-Mouth Disease Virus Genome Reveals Functional Elements Localized in the Polymerase (3D ^pol )-Encoding Region

mSphere, 2021
Some RNA structures formed by the genomes of RNA viruses are critical for viral replication. Our study shows that of 46 conserved RNA structures located within the regions of the foot-and-mouth disease virus (FMDV) genome that encode the nonstructural ...
Lidia Lasecka-Dykes, Fiona Tulloch, Peter Simmonds, Garry A. Luke, Paolo Ribeca, Sarah Gold, Nick J. Knowles, Caroline F. Wright, Jemma Wadsworth, Mehreen Azhar, Donald P. King, Tobias J. Tuthill, Terry Jackson, Martin D. Ryan   +13 more
doaj   +1 more source