Results 131 to 140 of about 4,116,626 (248)

IFI16 restricts SARS-CoV-2 replication by disrupting nucleocapsid-driven phase separation

Communications Biology
IFI16 is an interferon-inducible protein that senses viral DNA and can also restrict RNA virus replication. Here, using IFI16 knockout cellular models, we identify IFI16 as a host restriction factor that limits SARS-CoV-2 replication.
Ilaria Cislaghi, Sarah Turati, Dalila Vicario, Gloria Griffante, Shikha Chandel, Irene Lo Cigno, Ranieri Bizzarri, Barbara Storti, Tina Ukmar Godec, Milan Zachrdla, Markus Zweckstetter, Lucia Signorini, Kevin Kamau Maina, Serena Delbue, Cinzia Borgogna, Marisa Gariglio   +15 more
doaj   +1 more source

In Silico Analysis of Mutated SARS-CoV-2 N Protein of Java Origin and Human IgG Antibody as a Potential Vaccine Candidate [PDF]

EPJ Web of Conferences
The high mutation rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) may alter viral protein structures and reduce the effectiveness of vaccines that primarily target the spike (S) protein.
Maylina Mulyo Tjahyani Wenny, Rosa Putra Surya, Maulidya Cahyani Devy, Sarasitha Hariawan Henri Berlian   +3 more
doaj   +1 more source

Strategies for enhancing sensitivity in lateral flow assays

VIEW, EarlyView.
Lateral flow assays (LFAs) are essential for cost‐effective, rapid point‐of‐care diagnostics. However, conventional colourimetric LFAs often lack the sensitivity required for low‐abundance biomarkers. This review evaluates six enhancement strategies: flow modulation, sample preconcentration, advanced reporters, chemical signal amplification, structural
Aylar Eslami Saed, Jacopo Giaretta, Syamak Farajikhah, Fariba Dehghani   +3 more
wiley   +1 more source

Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid [PDF]

The viral genome of SARS-CoV-2 is packaged by the nucleocapsid (N-)protein into ribonucleoprotein particles (RNPs), 38 ± 10 of which are contained in each virion. Their architecture has remained unclear due to the pleomorphism of RNPs, the high
Syed, Abdullah M, Ott, Melanie, Nguyen, Ai, Srinivasan, Sanjana, Piszczek, Grzegorz, Ciling, Alison, Wu, Di, Schuck, Peter, Zhao, Huaying, Khalid, Mir M, Yau, Wai-Ming, Esposito, Dominic, Doudna, Jennifer A   +12 more
core   +1 more source

Naturally Occurring ZCCHC3 Variants Modulate Antiretroviral Activity in Cynomolgus Macaques

Microbiology and Immunology, EarlyView.
ABSTRACT Many mammalian cells restrict viral replication by utilizing various host restriction factors. We recently demonstrated that CCHC‐type zinc‐finger‐containing protein 3 (ZCCHC3) suppresses human immunodeficiency virus type 1 (HIV‐1) replication through multiple mechanisms.
Jacob Fadipe, Tomotaka Okamura, Shige H. Yoshimura, Akatsuki Saito   +3 more
wiley   +1 more source

Molecular modeling of viral nucleocapsid protein Zn fingers modulators [PDF]

, 2016
24-38The relationship between the biological activity and the physicochemical properties of agents is well documented. Using QSAR methodology, three different methods viz.
Paliwal, Sarvesh, Sharma, Shweta, Singh, Smrita, Akhter, Mymoona   +3 more
core  

Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs [PDF]

, 2003
Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated.
Boyd, A., Boyd, A, Fazakerley, John K., Weber, F, Elliott, Richard M., Fazakerley, John K, Weber, Friedemann, Weber, F., Streitenfeld, Hein, J. K. Fazakerley, Elliott, Richard M, Boyd, Amanda, H. Streitenfeld, Elliott, R.M., Streitenfeld, H., A. Bridgen, Bridgen, A., Streitenfeld, H, Fazakerley, J K, Fazakerley, J.K., F. Weber, R. M. Elliott, Bridgen, A, Elliott, Richard Michael, Bridgen, Anne, A. Boyd   +25 more
core   +1 more source

Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination

Allergy, EarlyView.
We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera, Benjamin Schwarz, Brittany Dulek, Ian S. LaCroix, Min Li, Lindsay Chatman, Muhammad B. Khalid, Ellen Zektser, Karen Laky, Stella Hartono, Eric Bohrnsen, Cole D. Kimzey, Eric Chu, Roa Harb, Pamela A. Frischmeyer‐Guerrerio   +14 more
wiley   +1 more source

The Dynamic Landscape of Capsid Proteins and Viral RNA Interactions in Flavivirus Genome Packaging and Virus Assembly

Pathogens
The Flavivirus genus of the Flaviviridae family of enveloped single-stranded RNA viruses encompasses more than 70 members, many of which cause significant disease in humans and livestock.
Anastazia Jablunovsky, Joyce Jose
doaj   +1 more source

Cell surface RNA virus nucleocapsid proteins: a viral strategy for immunosuppression?

npj Viruses
AbstractNucleocapsid protein (N), or nucleoprotein (NP) coats the genome of most RNA viruses, protecting and shielding RNA from cytosolic RNAases and innate immune sensors, and plays a key role in virion biogenesis and viral RNA transcription. Often one of the most highly expressed viral gene products, N induces strong antibody (Ab) and T cell ...
Alberto Domingo López-Muñoz, Jonathan W. Yewdell   +1 more
openaire   +3 more sources