Results 81 to 90 of about 4,116,626 (248)

Inhibition of Endosomal Transport Results in Decreased Synthesis of Nucleocapsid Protein of PHV Virus [PDF]

Учёные записки Казанского университета: Серия Естественные науки, 2017
This paper is devoted to investigation of molecular mechanisms of transport of nucleocapsid protein of non-pathogenic virus Prospect Hill. Prospect Hill virus (PHV) belongs to the family Bunyaviridae, genus Hantavirus.
M. Muyangwa, E.E. Garanina
doaj  

The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development

Emerging Microbes and Infections, 2023
The coronavirus disease 2019 (COVID-19) has caused enormous health risks and global economic disruption. This disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Haiyun Yu, Fei Guan, Heather Miller, Jiahui Lei, Chaohong Liu   +4 more
doaj   +1 more source

An ATP‐Driven N Protein–DDX21 Molecular Switch Dynamically Controls SARS‐CoV‐2 RNA G‐Quadruplex Heterogeneity

Advanced Science, EarlyView.
An ATP‐driven molecular switch, comprising viral nucleocapsid (N) protein and host helicase DDX21, dynamically modulates SARS‐CoV‐2 RNA G‐quadruplex (G4) heterogeneity. These viral G4s feature non‐canonical ion‐dependence and act as energy‐sensitive structural checkpoints.
Ya‐Ting Zheng, Li‐Yan Zhai, Jie Jin, Qiu‐Ying Chen, Hang Fu, Xue‐Qian Sun, Ying Lu, Hui Li, Xi‐Miao Hou   +8 more
wiley   +1 more source

Characterization and interactome study of white spot syndrome virus envelope protein VP11. [PDF]

PLoS ONE, 2014
White spot syndrome virus (WSSV) is a large enveloped virus. The WSSV viral particle consists of three structural layers that surround its core DNA: an outer envelope, a tegument and a nucleocapsid.
Wang-Jing Liu, Hui-Jui Shiung, Chu-Fang Lo, Jiann-Horng Leu, Ying-Jang Lai, Tai-Lin Lee, Wei-Tung Huang, Guang-Hsiung Kou, Yun-Shiang Chang   +8 more
doaj   +1 more source

Electrochemical Detection of SARS-CoV-2 Using Immunomagnetic Separation and Gold Nanoparticles on Unmodified Screen-Printed Carbon Electrodes

Applied Sciences, 2023
The COVID-19 pandemic has underscored the critical need for virus detection methods that are precise, simple, quick, and cost-effective. Electrochemical immunoassay-based methods are a practical solution given their ability to quickly, inexpensively ...
Christopher J. Lambert, Harikrishnan Jayamohan, Bruce K. Gale, Lars B. Laurentius, Dhruv Patel, Madison Hansen, Tawsif Mahmood, Himanshu Jayant Sant   +7 more
doaj   +1 more source

Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli

Advanced Science, EarlyView.
Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma, Yuxin Zhang, Lujia Sun, Hong Jiang, Fan Li, Wenming Liu, Shenao Zhou, Mengting Wang, Weijian Huang, Xu Zhou, Caiyang Chen, Qiuqiu Zhang, Xiaoyan Jin, Feihan Yan, Hongping Wu, Yonghong Yin, Xinling Wang, Hexin Yan, Weifeng Yu   +18 more
wiley   +1 more source

The role of viral genomic RNA and nucleocapsid protein in the autophagic clearance of hantavirus glycoprotein Gn [PDF]

Virus Research, 2014
Hantaviruses have tri-segmented negative sense RNA genome. The viral M-segment RNA encodes a glycoprotein precursor (GPC), which is cleaved into two glycoprotein molecules Gn and Gc that form spikes on the viral envelope. We previously reported that Gn is degraded shortly after synthesis by the host autophagy machinery.
Safder S, Ganaie, Mohammad A, Mir
openaire   +2 more sources

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

The Measles Virus Nucleocapsid Protein Tail Domain Is Dispensable for Viral Polymerase Recruitment and Activity [PDF]

Journal of Biological Chemistry, 2013
Paramyxovirus genomes are ribonucleoprotein (RNP) complexes consisting of nucleoprotein (N)-encapsidated viral RNA. Measles virus (MeV) N features an amino-terminal RNA-binding core and a 125-residue tail domain, of which only the last 75 residues are considered fully mobile on the nucleocapsid surface.
Stefanie A, Krumm, Makoto, Takeda, Richard K, Plemper   +2 more
openaire   +2 more sources

One for all? A viral protein supplants the mRNA cap-binding complex [PDF]

, 2009
Modulation of the host cell’s translational machinery is a crucial part of viral infection strategies.Well-characterised mechanisms that aid viruses in manipulating translational activity include, for example, internal ribosomal entry sites, which allow ...
von der Haar, Tobias
core   +1 more source