Results 231 to 240 of about 1,219,846 (287)

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Oncolytic Viruses for Cancer Therapy in Dogs. [PDF]

Viruses
Neymysheva DO, Ilyinskaya GV, Sarkisova VA, Mukhina EA, Romanen-Kova SA, Chumakov PM.   +5 more
europepmc   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

A natural five-amino-acid insert at the S2' cleavage site of MERS-CoV spike enhances viral membrane fusion. [PDF]

Virol Sin
Dai G, Chen W, Cao W, Zhang G.
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Tea Polyphenols in the COVID-19 Era: Mechanistic Insights and Translational Challenges. [PDF]

Curr Issues Mol Biol
Chang H, Wu CS, Yeh TY, Ko WC.
europepmc   +1 more source

Role of cardiac mast cells in cardiovascular diseases: a review. [PDF]

PeerJ
Wang LM, Ye LF, Wei J, Jiang ZY, Lu HX.
europepmc   +1 more source

Moringa oleifera potential for the treatment and prevention of COVID-19 involving molecular interaction, antioxidant properties and kinetic mechanism. [PDF]

PLoS One
Hamadou M, Bakwo Bassogog CB, Obadias FV, Assaly AD, Mune Mune MA.   +4 more
europepmc   +1 more source

3-Amidinophenylalanine-Derived Inhibitors' Antiviral Effect Against H1N1 Influenza A Virus. [PDF]

Antibiotics (Basel)
Tóth L, Marosi A, Schmacke LC, Steinmetzer T, Rácz A, Bajusz D, Jerzsele Á, Kunsági-Máté S, Poór M, Pászti-Gere E.   +9 more
europepmc   +1 more source

Furin as a Novel Pan-Viral Therapeutic Target: Implications for Dengue and SARS-CoV-2. [PDF]

Viruses
Shalaby L, Al-Haneedi Y, Abdelhamid A, Yassine H, Emara MM.   +4 more
europepmc   +1 more source