Results 251 to 260 of about 1,219,846 (287)

Multiple proteases process viral antigens for presentation by MHC class I molecules to CD8+ T lymphocytes [PDF]

Molecular Immunology, 2002
Recognition by CD8(+) cytotoxic T lymphocytes of any intracellular viral protein requires its initial cytosolic proteolytic processing, the translocation of processed peptides to the endoplasmic reticulum via the transporters associated with antigen ...
Daniel Lopez
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HIV protease resistance and viral fitness

Current Opinion in HIV and AIDS, 2007
This review focuses on the evolution of protease inhibitor resistance and replication capacity in the presence and absence of protease inhibitor pressure.Classically, HIV escapes through mutations in the protease itself causing a decrease in affinity to the inhibitor, leading to resistance.
Monique, Nijhuis, Noortje M, van Maarseveen, Charles A B, Boucher   +2 more
openaire   +2 more sources

Viral therapy: Prospects for protease inhibitors

Journal of Cellular Biochemistry, 1986
AbstractAntiviral activities of known protease inhibitors were assayed in virus‐infected cell cultures. Some members of the cystatin superfamily, in particular chicken cystatin, were able to block virus replication. In a binding assay, using purified components, chicken and human cystatin were able to bind poliovirus protease with affinities which were
B D, Korant, T, Towatari, L, Ivanoff, S, Petteway, J, Brzin, B, Lenarcic, V, Turk   +6 more
openaire   +2 more sources

Membrane-Anchored Serine Proteases: Host Cell Factors in Proteolytic Activation of Viral Glycoproteins

Activation of Viruses by Host Proteases, 2018
Over one third of all known proteolytic enzymes are serine proteases. Among these, the trypsin-like serine proteases comprise one of the best characterized subfamilies due to their essential roles in blood coagulation, food digestion, fibrinolysis, or ...
E. Böttcher-Friebertshäuser
semanticscholar   +1 more source

Serum protease inhibitors in acute viral hepatitis

La Ricerca in Clinica e in Laboratorio, 1987
Serum levels of alpha 1-antitrypsin (alpha 1-AT) and alpha 2-macroglobulin (alpha 2-M) and, as controls, alpha 1-acid glycoprotein (alpha 1-AG) and haptoglobin were evaluated by means of laser nephelometry in 17 patients with acute viral hepatitis (AVH) type A, 16 with AVH-B, 12 with AVH-NANB and 8 with fulminant hepatitis B.
R, Meliconi, O, Parracino, A, Facchini, G, Verucchi, F, Chiodo, M L, Schiattone, F, Miglio, G, Gasbarrini   +7 more
openaire   +2 more sources

Viral Proteases: An Emerging Therapeutic Target

Critical Reviews in Biotechnology, 1988
Only a few viral diseases are presently treatable because of our limited knowledge of specific viral target molecules. An attractive class of viral molecules toward which chemotherapeutic agents could be aimed are proteases coded by some virus groups such as retro- or picornaviruses (poliomyelitis, common cold virus).
openaire   +2 more sources

CRISPR/Cas12a Protein Switch Powered Label-Free Electrochemical Biosensor for Sensitive Viral Protease Detection.

Analytical Chemistry
Viral proteases are critical molecular targets in viral pathogenesis, representing pivotal biomarkers for understanding viral infection mechanisms and developing antiviral therapeutics.
Tianyi Zhang, Yingying Zhao, Cong Zhu, Xi Zhu, Xiaohua Zhu, Ye Qiu, Zhou Nie, Chunyang Lei   +7 more
semanticscholar   +1 more source

Genetic - Based Assays of Viral Proteases

1999
Many viruses code for specialized proteolytic enzymes which are essential for virus assembly (Korant, 1994). The viral enzymes appear to belong to one of the recognized protease classes, including serine, cysteine and aspartic active sites, but some novel combinations have also been identified, including a cysteine active site residue participating in ...
C. Rizzo, Y.-S. E. Cheng, B. Korant
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Serine protease inhibitors in patients with chronic viral hepatitis

Journal of Hepatology, 1997
This study aimed to determine whether deficiency of the major serine protease inhibitors (alpha1-antitrypsin (AAT) or alpha1-antichymotrypsin (ACT)) is associated with increased risk for chronic hepatitis B or C virus (HBV or HCV) infection.We studied 709 adults with chronic liver disease who had undergone liver biopsy during the 14-year period 1978-92.
A N, Elzouki, H, Verbaan, S, Lindgren, A, Widell, J, Carlson, S, Eriksson   +5 more
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Viral proteases and phosphorodiesterase inhibitors.

IDrugs : the investigational drugs journal, 2005
A number of novel drug candidates, which are at different stages of development and various therapeutic targets, mechanisms of action and clinical data were discussed in depth. Crystallographic studies and structures of several viral proteases were outlined and described.
openaire   +1 more source