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Interactions between a viral protease and cystatins.
Biological chemistry Hoppe-Seyler, 1989The interactions of two cystatins with a viral cysteine protease were studied using several types of assays. Complex formation between the protease and inhibitor was directly demonstrated using a gel retardation assay. It was also shown that the formation of enzyme inhibitor complexes could occur after first binding either the enzyme or the inhibitor ...
B, Korant +5 more
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The peptidomimetic approach for the design of viral protease inhibitors
The transformation of peptides into drug leads is an established approach in medicinal chemistry and drug discovery. Peptidomimetics are designed to mimic the bioactivity of peptides while addressing their limitations, such as poor metabolic stability and low bioavailability, thus resulting in improved receptor affinity and selectivity.openaire +2 more sources
Computational approaches for designing viral protease inhibitors
Viral proteases are critical enzymes that play essential roles in the replication of viruses such as Human Immunodeficiency, Hepatitis C, SARS-CoV-2, Zika, Dengue, West Nile, Yellow Fever, Japanese and Saint Louis Encephalitis, Tick-Born Encephalitis, Chikungunya, and others.openaire +3 more sources
Viral Proteases and Their Inhibitors: Preface
Viral Proteases and Their Inhibitors, 2017semanticscholar +1 more source
Recent advances in targeting viral proteases for the discovery of novel antivirals.
Current Topics in Medicinal Chemistry, 2010H. Steuber, R. Hilgenfeld
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