Results 11 to 20 of about 928,330 (381)
Viruses and viral proteins [PDF]
IUCrJ, 2014 For more than 30 years X-ray crystallography has been by far the most powerful approach for determining the structures of viruses and viral proteins at atomic resolution.
Nuria Verdaguer +2 more
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Viral Hijacking of BET Proteins
Viruses, 2022 Proteins of the bromodomain and exterminal domain (BET) family mediate critical host functions such as cell proliferation, transcriptional regulation, and the innate immune response, which makes them preferred targets for viruses.
Irene P. Chen, Melanie Ott
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Viral organization of human proteins. [PDF]
PLoS ONE, 2010 Although maps of intracellular interactions are increasingly well characterized, little is known about large-scale maps of host-pathogen protein interactions. The investigation of host-pathogen interactions can reveal features of pathogenesis and provide
Stefan Wuchty +2 more
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Current progress on innate immune evasion mediated by Npro protein of pestiviruses
Frontiers in Immunology, 2023 Interferon (IFN), the most effective antiviral cytokine, is involved in innate and adaptive immune responses and is essential to the host defense against virus invasion. Once the host was infected by pathogens, the pathogen-associated molecular patterns (
Shubo Wen +12 more
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SUMOylation in Viral Replication and Antiviral Defense
Advanced Science, 2022 SUMOylation is a ubiquitination‐like post‐translational modification that plays an essential role in the regulation of protein function. Recent studies have shown that proteins from both RNA and DNA virus families can be modified by SUMO conjugation ...
Yao Fan +10 more
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Biomolecules, 2022 Novel and efficient strategies need to be developed to interfere with the SARS-CoV-2 virus. One of the most promising pharmaceutical targets is the nucleocapsid protein (N), responsible for genomic RNA packaging.
Marco Schiavina +4 more
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Mimicry between respiratory virus proteins and some human immune proteins
Инфекция и иммунитет, 2020 A comparative analysis on search for amino acid sequences in viral proteins causing respiratory infections (or respiratory infections syndrome) homologous to amino acid sequences from some human immune proteins was performed.
I. N. Zhilinskaya
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The Viral Protein Corona Directs Viral Pathogenesis and Amyloid Aggregation [PDF]
Nature Communications, 2018 AbstractArtificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes
Samir El Andaloussi +31 more
openaire +8 more sources
Specific Deubiquitinating Enzymes Promote Host Restriction Factors Against HIV/SIV Viruses
Frontiers in Immunology, 2021 Hijacking host ubiquitin pathways is essential for the replication of diverse viruses. However, the role of deubiquitinating enzymes (DUBs) in the interplay between viruses and the host is poorly characterized. Here, we demonstrate that specific DUBs are
Wenying Gao +12 more
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De Novo synthesis of VP16 coordinates the exit from HSV latency in vivo [PDF]
, 2009 The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade
Preston, C.M. +2 more
core +9 more sources