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SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns
Frontiers in Immunology, 2021 There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles during infection are still not completely understood.
Natalia Redondo +3 more
semanticscholar +1 more source
Expansion of Viral Genomes with Viral Protein Genome Linked Copies
SSRN Electronic Journal, 2022 Virus protein-linked genome (VPg) proteins are required for replication. VPgs are duplicated in a subset of RNA viruses however their roles are not fully understood and the extent of viral genomes containing VPg copies has not been investigated in detail.
Reid, Warsaba +3 more
openaire +2 more sources
Design of a Multiepitope Vaccine against Chicken Anemia Virus Disease
Viruses, 2022 Chicken anemia virus (CAV) causes severe clinical and sub-clinical infection in poultry globally and thus leads to economic losses. The drawbacks of the commercially available vaccines against CAV disease signal the need for a novel, safe, and effective ...
Abiodun Joseph Fatoba +5 more
doaj +1 more source
Defective HIV-1 proviruses produce viral proteins
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance In HIV-infected patients on combination antiretroviral therapy (cART), greater than 95% of proviruses in the peripheral blood are “defective.” Historically, these defective proviruses have been thought to be dead-end products with no real ...
H. Imamichi +11 more
semanticscholar +1 more source
Role of Heat Shock Proteins (HSP70 and HSP90) in Viral Infection
International Journal of Molecular Sciences, 2021 Heat shock proteins (HSPs) are a large group of chaperones found in most eukaryotes and bacteria. They are responsible for the correct protein folding, protection of the cell against stressors, presenting immune and inflammatory cytokines; furthermore ...
A. Lubkowska +3 more
semanticscholar +1 more source
Frontiers in Microbiology, 2021 Cells respond to viral infections through sensors that detect non-self-molecules, and through effectors, which can have direct antiviral activities or adapt cell physiology to limit viral infection and propagation.
Teresa Cesaro, Thomas Michiels
doaj +1 more source
Evasion of interferon-mediated immune response by arteriviruses
Frontiers in Immunology, 2022 IFN is the most potent antiviral cytokine required for the innate and adaptive immune responses, and its expression can help the host defend against viral infection.
Zhijie Jian +14 more
doaj +1 more source
Programming Dynamic Assembly of Viral Proteins with DNA Origami.
Journal of the American Chemical Society, 2020 Biomolecular assembly in biological systems is typically a complex dynamic process regulated by the exchange of molecular information between biomolecules such as proteins and nucleic acids.
Kun Zhou +4 more
semanticscholar +1 more source
Assembly of Viral Membrane Proteins [PDF]
Journal of Chemical Theory and Computation, 2009 The generation of computational models is an alternative route to obtain reliable structures for the oligomeric state of membrane proteins. A strategy has been developed to search the conformational space of all possible assemblies in a reasonable time, taking symmetry considerations into account. The methodology tested on M2 from influenza A, shows an
J, Krüger, W B, Fischer
openaire +2 more sources
Influenza B: Prospects for the Development of Cross-Protective Vaccines
Viruses, 2022 In this review, we analyze the epidemiological and ecological features of influenza B, one of the most common and severe respiratory infections. The review presents various strategies for cross-protective influenza B vaccine development, including ...
Liudmila M. Tsybalova +3 more
doaj +1 more source