Results 21 to 30 of about 928,330 (381)
IEEE Access, 2023 Automatic analysis of colocalizing biological structures in multi-channel fluorescence microscopy images is an important task to quantify and understand biological processes at high spatial-temporal resolution.
Christian Ritter +5 more
doaj +1 more source
Engineering multiple levels of specificity in an RNA viral vector [PDF]
, 2020 Synthetic molecular circuits could provide powerful therapeutic capabilities, but delivering them to specific cell types and controlling them remains challenging.
Chong, Lucy S. +4 more
core +1 more source
European Biophysics Journal, 2009 This special issue on ‘Viral membrane proteins’ incorporates a series of research articles that were presented at the ‘Conference on Viral Membrane Proteins’, held at the University of Heidelberg, Germany, on 12–14 December 2008. The aim of the symposium was to involve all areas of research in this emerging Weld focusing on biophysical and clinically ...
Gerhard Thiel +2 more
openaire +2 more sources
Therapeutic Interfering Particles Exploiting Viral Replication and Assembly Mechanisms Show Promising Performance: A Modelling Study [PDF]
Scientific Reports, 11, 23847 (2021), 2021 Defective interfering particles arise spontaneously during a viral infection as mutants lacking essential parts of the viral genome. Their ability to replicate in the presence of the wild-type (WT) virus (at the expense of viable viral particles) is mimicked and exploited by therapeutic interfering particles.
arxiv +1 more source
Evolution of SLiM-mediated hijack functions in intrinsically disordered viral proteins [PDF]
, 2023 Viruses and their hosts are involved in an 'arms race' where they continually evolve mechanisms to overcome each other. It has long been proposed that intrinsic disorder provides a substrate for the evolution of viral hijack functions and that short linear motifs (SLiMs) are important players in this process. Here, we review evidence in support of this
arxiv +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 The ongoing pandemic caused by the novel coronavirus (SARS-CoV-2) has led to more than 445 million infections and the underlying disease, COVID-19, resulted in more than 6 million deaths worldwide.
Franziska Ramm +11 more
doaj +1 more source
Biophysical Modeling of SARS-CoV-2 Assembly: Genome Condensation and Budding [PDF]
Viruses 2022, 14, 2089, 2022 The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spurred unprecedented and concerted worldwide research to curtail and eradicate this pathogen. SARS-CoV-2 has four structural proteins: Envelope (E), Membrane (M), Nucleocapsid (N), and Spike (S), which self-assemble along with its RNA into the ...
arxiv +1 more source
Solid-State NMR for Studying the Structure and Dynamics of Viral Assemblies
Viruses, 2020 Structural virology reveals the architecture underlying infection. While notably electron microscopy images have provided an atomic view on viruses which profoundly changed our understanding of these assemblies incapable of independent life ...
Lauriane Lecoq +4 more
doaj +1 more source
A multitask transfer learning framework for the prediction of virus-human protein-protein interactions [PDF]
BMC Bioinformatics 2021, 2021 Viral infections are causing significant morbidity and mortality worldwide. Understanding the interaction patterns between a particular virus and human proteins plays a crucial role in unveiling the underlying mechanism of viral infection and pathogenesis. This could further help in the prevention and treatment of virus-related diseases.
arxiv +1 more source
Steve Oroszlan: A Personal Perspective
Viruses, 2021 My memories of Steve go back over 50 years. While precise dates are no longer in my memory bank, circumstances and emotions remain alive and easy to recall.
Raymond Gilden
doaj +1 more source