Results 31 to 40 of about 6,360,309 (211)
HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread [PDF]
, 2016 open access articleHIV-1 spreads between CD4 T cells most efficiently through virus-induced cell-cell contacts. To test whether this process potentiates viral spread by activating signaling pathways, we developed an approach to analyze the ...
Jolly, Clare +3 more
core +2 more sources
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
Nature, 2020 The papain-like protease PLpro is an essential coronavirus enzyme that is required for processing viral polyproteins to generate a functional replicase complex and enable viral spread 1 , 2 .
Donghyuk Shin +21 more
semanticscholar +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Western and dot immunoblotting analysis of viral antigens and antibodies: application to murine hepatitis virus. [PDF]
, 1984 Viral proteins were separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and transferred quantitatively to nitrocellulose by electroblotting in SDS-containing buffer.
Buchmeier, MJ, Knobler, RL, Talbot, PJ
core
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Mining viral proteins for antimicrobial and cell-penetrating drug delivery peptides
Bioinform., 2015 MOTIVATION The need for more effective and safer pharmaceuticals is a persistent quest. Microbial adaptations create the need to permanently develop new antimicrobials (AMPs), for instance.
J. Freire +4 more
semanticscholar +1 more source
Human colon organoid differentiation from induced pluripotent stem cells using an improved method
FEBS Letters, Volume 599, Issue 6, Page 912-924, March 2025.We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee +4 more
wiley +1 more source
The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1) [PDF]
, 2016 Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting
Boutell, Chris +7 more
core +1 more source
Regulation of Ribosomal Proteins on Viral Infection
Cells, 2019 Ribosomal proteins (RPs), in conjunction with rRNA, are major components of ribosomes involved in the cellular process of protein biosynthesis, known as “translation”.
S. Li
semanticscholar +1 more source
FEBS Letters, Volume 599, Issue 7, Page 952-970, April 2025.The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang +9 more
wiley +1 more source