Results 31 to 40 of about 995,700 (356)
Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins [PDF]
, 2017 Using a high throughput screening methodology we surveyed a collection of largely uncharacterized validated or suspected kinase inhibitors for anti-human cytomegalovirus (HCMV) activity.
Beelontally, Rooksarr +10 more
core +2 more sources
APOBEC3 Proteins in Viral Immunity [PDF]
The Journal of Immunology, 2015 Abstract Apolipoprotein B editing complex 3 family members are cytidine deaminases that play important roles in intrinsic responses to infection by retroviruses and have been implicated in the control of other viruses, such as parvoviruses, herpesviruses, papillomaviruses, hepatitis B virus, and retrotransposons.
Spyridon Stavrou, Susan R Ross
openaire +3 more sources
Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins. [PDF]
, 2019 The plasma membrane is a site of conflict between host defenses and many viruses. One aspect of this conflict is the host's attempt to eliminate infected cells using innate and adaptive cell-mediated immune mechanisms that recognize features of the ...
Guatelli, John +5 more
core +1 more source
Unconventional secretion of viral proteins
Seminars in Cell & Developmental Biology, 2018 Although largely less numerous and characterized than bacterial secreted effectors, several viral virulence factors are secreted by virus infected cells. However, their mode of secretion only starts to be studied at the molecular level. Several of these viral effectors are secreted using an unconventional secretion pathway, i.e.
Schatz, Malvina +2 more
openaire +4 more sources
USP7 manipulation by viral proteins
Virus Research, 2020 Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB) that plays critical roles in the regulation of many cellular processes including epigenetics, tumour suppression, oncogenesis, DNA damage response, immunity and viral infection. USP7 was the first DUB associated with viral infection.
Anna Bojagora, Vivian Saridakis
openaire +3 more sources
Viral Proteins as Emerging Cancer Therapeutics [PDF]
Cancers, 2021 Viruses are obligatory intracellular parasites that originated millions of years ago. Viral elements cover almost half of the human genome sequence and have evolved as genetic blueprints in humans. They have existed as endosymbionts as they are largely dependent on host cell metabolism.
Manocha E., Caruso A., Caccuri F.
openaire +3 more sources
Characterization and subcellular localization of Alongshan virus proteins
Frontiers in Microbiology, 2022 Alongshan virus (ALSV) in the Jingmenvirus group within the family Flaviviridae is a newly discovered tick-borne virus associated with human disease, whose genome includes four segments and encodes four structural proteins (VP1a, VP1b, VP2, VP3, and VP4)
Yinghua Zhao +13 more
doaj +1 more source
Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry [PDF]
, 2012 Protein phosphorylation is a common post-translational modification in eukaryotic cells and has a wide range of functional effects. Here, we used mass spectrometry to search for phosphorylated residues in all the proteins of influenza A and B viruses ...
Denham, Eleanor M. +8 more
core +3 more sources
Human immunodeficiency virus type 1: Role of proteins in the context of viral life cycle
Journal of Advanced Biotechnology and Experimental Therapeutics, 2022 The Acquired Immunodeficiency Syndrome (AIDS) is a major global pandemic and of paramount public health concern. Over the years, antiretroviral therapy (ART) has emerged as the gold standard of AIDS treatment.
Vikas Jha +8 more
doaj +1 more source
Журнал инфектологии, 2017 Objectives: To identify homologous segments of human hemostatic and viral proteins and to assess the role of human hemostatic proteins in viral replication. Materials and Methods: The following viruses were chosen for comparison: influenza B (B/Astrakhan/
I. N. Zhilinskaya +3 more
doaj +1 more source