Internal perturbations of homoclinic classes:non-domination, cycles, and self-replication [PDF]
Conditions are provided under which lack of domination of a homoclinic class yields robust heterodimensional cycles. Moreover, so-called viral homoclinic classes are studied. Viral classes have the property of generating copies of themselves producing wild dynamics (systems with infinitely many homoclinic classes with some persistence).
arxiv
Lymphotoxins and cytomegalovirus cooperatively induce interferon-beta, establishing host-virus détente [PDF]
Tumor necrosis factor (TNF)-related cytokines regulate cell death and survival and provide strong selective pressures for viruses, such as cytomegalovirus (CMV), to evolve counterstrategies in order to persist in immune-competent hosts.
Angulo, A+7 more
core +1 more source
Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet+6 more
wiley +1 more source
Chemokine expression and viral infection of the central nervous system: regulation of host defense and neuropathology. [PDF]
An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it
Lane, TE, Liu, MT
core
Viral Genome Segmentation Can Result from a Trade-Off between Genetic Content and Particle Stability [PDF]
The evolutionary benefit of viral genome segmentation is a classical, yet unsolved question in evolutionary biology and RNA genetics. Theoretical studies anticipated that replication of shorter RNA segments could provide a replicative advantage over ...
Arias, Armando+7 more
core +3 more sources
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran+3 more
wiley +1 more source
Symposium on replication of viral nucleic acids. 3. Replication of mengovirus ribonucleic acid. [PDF]
Peter G.W. Plagemann, H E Swim
openalex +2 more sources
Background Replication of the vaccinia virus genome occurs in cytoplasmic factory areas and is dependent on the virus-encoded DNA polymerase and at least four additional viral proteins.
Moss Bernard, De Silva Frank S
doaj +1 more source
Enterovirus Replication Organelles and Inhibitors of Their Formation
Enteroviral replication reorganizes the cellular membrane. Upon infection, viral proteins and hijacked host factors generate unique structures called replication organelles (ROs) to replicate their viral genomes.
Xinhong Li+62 more
doaj +1 more source
Intrahost Selection Pressures Drive Rapid Dengue Virus Microevolution in Acute Human Infections. [PDF]
Dengue, caused by four dengue virus serotypes (DENV-1 to DENV-4), is a highly prevalent mosquito-borne viral disease in humans. Yet, selection pressures driving DENV microevolution within human hosts (intrahost) remain unknown. We employed a whole-genome
Balmaseda, Angel+6 more
core +1 more source