Results 161 to 170 of about 2,155,361 (380)

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

open access: yesAdvanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson   +12 more
wiley   +1 more source

Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1

open access: yesCell Reports, 2019
Summary: Long noncoding RNAs (lncRNAs) participate in host antiviral defense by modulating immune responses. However, it remains largely unexplored how viruses exploit interferon (IFN)-independent host lncRNAs to facilitate viral replication.
Jing Wang   +13 more
doaj  

Spring viraemia of carp virus induces autophagy for necessary viral replication

open access: yesCellular Microbiology, 2015
Outbreaks of spring viraemia of carp virus (SVCV) in several carp species and other cultivated fish can cause significant mortality and jeopardize the billion‐dollar worldwide fish industry. Spring viraemia of carp virus, also known as Rhabdovirus carpio,
Liyue Liu   +14 more
semanticscholar   +1 more source

Detection of viral replication in bees

open access: yesJulius-Kühn-Archiv, 2012
Recently foraging bees were discovered with pollen loads infected with honey bee viruses uncorrelated with the infection status of the bees itself. This observation has wide implications on the broadly used PCR viral detection techniques. False positives results could be obtained if viral remnants from infected pollen in the bee gut are detected ...
Ivan Meeus   +2 more
openaire   +3 more sources

Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

open access: yesAdvanced Functional Materials, EarlyView.
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput   +5 more
wiley   +1 more source

Efficient HIV-1 in vitro reverse transcription: optimal capsid stability is required

open access: yesSignal Transduction and Targeted Therapy, 2021
Ryan C. Burdick, Vinay K. Pathak
doaj   +1 more source

G-quadruplex as an essential structural element in cytomegalovirus replication origin

open access: yesNature Communications
G-quadruplex (G4) structures are found in eukaryotic cell replication origins, but their role in origin function remains unclear. In this study G4 motifs are found in the lytic DNA replication origin (oriLyt) of human cytomegalovirus (HCMV) and ...
Daegyu Park   +7 more
doaj   +1 more source

Home - About - Disclaimer - Privacy