Results 161 to 170 of about 2,261,873 (405)

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Oligohistidine‐Functionalized Single‐Walled Carbon Nanotube‐Guided RNA Delivery to Improve Shoot Regeneration Efficiency in Plant Calli

Advanced Functional Materials, EarlyView.
The pH‐sensitive His6‐SWNTs, which is functionalized with oligohistidine, can deliver STTM396 molecules into callus cells. The STTM396–SWNT complex treatments enhance shoot regeneration efficiency by regulating the miR396‐GRF module in Arabidopsis and tomato calli.
Yeong Yeop Jeong, Hyuna Kwak, Woojin Jeong, Hongwoo Lee, Su‐Ji Jeon, Hyo‐Jun Lee, Pil Joon Seo, Seon‐Yeong Kwak   +7 more
wiley   +1 more source

Rice stripe mosaic virus encoded phosphoprotein forms viral factory-like granules and is crucial for viral replication

Phytopathology Research
Viral proteins can aggregate into granules within host cells, known as viral factories, or viroplasms, which play a pivotal role in facilitating viral replication and shielding the viral genome from cellular defense mechanisms.
Zhiyi Wang, Jingyi Zhang, Xinyue Song, Siping Chen, Xue Cao, Xin Yang, Guohui Zhou, Tong Zhang   +7 more
doaj   +1 more source

Human Parvovirus B19 Infection Causes Cell Cycle Arrest of Human Erythroid Progenitors at Late S Phase That Favors Viral DNA Replication [PDF]

, 2013
Yong Luo, Steve Kleiboeker, Xuefeng Deng, Jianming Qiu   +3 more
openalex   +1 more source

Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7

, 2021
Niluka Goonawardane, Dung Nguyen, Peter Simmonds   +2 more
openalex   +1 more source

Integrated Metallo‐Dielectric 3D Hotspots From High Refractive Index Nanodiamond‐Plasmonic Gold Cryosoret Nano‐Assemblies for Photonic Crystal Enhanced Fluorescence

Advanced Functional Materials, EarlyView.
This work presents a novel sensing platform using metallo‐dielectric cryosoret nano‐assemblies and lossless photonic crystals to overcome limitations of conventional plasmonic biosensors. The hybrid system enhances both electric and magnetic field interactions, enabling amplified fluorescence, ultralow detection limits, and prism‐free, objective‐free ...
Seemesh Bhaskar, Weinan Liu, Skye Shepherd, Devinda Wijewardena, Joseph Tibbs, Brian T. Cunningham   +5 more
wiley   +1 more source

Recombination is required for efficient HIV-1 replication and the maintenance of viral genome integrity [PDF]

, 2018
Jonathan Rawson, Olga A. Nikolaitchik, Brandon F. Keele, Vinay K. Pathak, Wei-Shau Hu   +4 more
openalex   +1 more source

FKBP‐type peptidyl‐prolyl cis‐trans isomerase interacts with the movement protein of tomato leaf curl New Delhi virus and impacts viral replication in Nicotiana benthamiana

, 2022
Ho‐Hsiung Chang, Chia‐Hwa Lee, Chung‐Jan Chang, Fuh‐Jyh Jan   +3 more
openalex   +1 more source

Gossypol Affects Viral Replication by Inhibiting Pseudorabies Virus Adsorption [PDF]

, 2023
Yilin Bai, Bing-Qian Su, Xuan Cheng, Qianwen Liu, Lei Zeng, Peng-Fei Fu   +5 more
openalex   +1 more source

Endoplasmic Reticulum Stress Induced Synthesis of a Novel Viral Factor Mediates Efficient Replication of Genotype-1 Hepatitis E Virus

PLoS Pathogens, 2016
Hepatitis E virus (HEV) causes acute hepatitis in many parts of the world including Asia, Africa and Latin America. Though self-limiting in normal individuals, it results in ~30% mortality in infected pregnant women.
V. Nair, Saumya Anang, Chandru Subramani, Abhilasha Madhvi, Karishma Bakshi, Akriti Srivastava, Shalimar, B. Nayak, R. Ct, Milan Surjit   +9 more
semanticscholar   +1 more source