Results 211 to 220 of about 436,485 (268)

Programmable Klebsiella pneumoniae Phage Tropism Enabled by Scalable Receptor‐Binding Protein Mining and Modular Assembly

Advanced Science, EarlyView.
This work introduces a scalable, data‐driven strategy that turns the vast sequence diversity of phage receptor‐binding proteins into modular tools for engineering customizable phages. By clustering and experimentally validating diverse RBPs, the authors build an accurate map linking sequence to host specificity and create plug‐and‐play modules that ...
Shisong Jing, Yiyao Song, Xianbiao Bi, Yuqin Song, Dawei Wei, Jiangqing Huang, Yuan Zeng, Gang Zhang, Rong Zhang, Chao Wang, Jie Feng   +10 more
wiley   +1 more source

Interaction of West Nile virus NS5 with orthoflavivirus SLA RNAs and their effects on viral replication and inhibition. [PDF]

J Virol
Feinberg MA, Le MT, Carpio KL, Knyazhanskaya E, Barrett ADT, Choi KH.   +5 more
europepmc   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

HBV p22-interacting protein C1QBP inhibits viral replication through impeding nucleocapsid formation and nuclear import. [PDF]

PLoS Pathog
Peng X, Liu CD, Mitra B, Kim ES, Sun N, Jurado A, Zhang H, Li S, Zhou T, Guo H.   +9 more
europepmc   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Regulation of viral replication by host restriction factors. [PDF]

Front Immunol
Lin Y, Zhu Y, Jing L, Lei X, Xie Z.
europepmc   +1 more source

Monkeypox virus induces ferroptosis to facilitate viral replication and promotes inflammatory responses. [PDF]

Emerg Microbes Infect
Chuai X, Wang Y, Wang C, Ye T, Shen X, Zhou J, Zhang K, Zhao B, Wu Y, Li W, Cai Z, Chiu S.   +11 more
europepmc   +1 more source

Sulfatide Binds to Influenza B Virus and Enhances Viral Replication. [PDF]

Viruses
Kurebayashi Y, Wakabayashi Y, Takahashi T, Sakakibara K, Takahashi S, Minami A, Suzuki T, Takeuchi H.   +7 more
europepmc   +1 more source

Deciphering pUL10's mastery in duck plague virus virulence: dual coordination of host immunity and viral replication. [PDF]

Poult Sci
Li C, Wang M, Cheng A.
europepmc   +1 more source

A conserved RNA structure at the capsid-coding sequence of Zika virus genome is required for viral replication in a host-dependent manner. [PDF]

J Virol
Costa Navarro GS, Pallarés HM, González López Ledesma MM, de Borba L, Mazzolenis R, Gamarnik AV.   +5 more
europepmc   +1 more source