Effect of Viral Double-Stranded RNA on Mammalian Cells in Culture: Cytotoxicity Under Conditions Preventing Viral Replication and Protein Synthesis [PDF]
, 1973 B. Cordell-Stewart, Milton W. Taylor
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Multi-point Infection Dynamics of Hepatitis B in the Presence of Sub-Viral Particles [PDF]
arXivHepatitis B virus (HBV) is considered as etiological agent of the lethal liver disease hepatitis B. Globally, hepatitis B is recognized as one of the prevailing infectious diseases with a significant impact on human health. In spite of being non-infectious in nature, sub-viral particles (SVPs) , composed with mainly viral surface proteins, play ...
arxiv
Advanced Theory and Simulations, EarlyView.The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak +2 more
wiley +1 more source
Replication of viral RNA. XI. Synthesis of viral "minus" strands in vitro.
, 1966 C. Weissmann, G. Feix
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Global bifurcation in a virus, defective genomes, satellite RNAs tripartite system: breakdown of a coexistence quasi-neutral curve [PDF]
arXivThe dynamics of wild-type (wt) RNA viruses and their defective viral genomes (DVGs) have been extensively studied both experimentally and theoretically. This research has paid special attention to the interference effects of DVGs on wt accumulation, transmission, disease severity, and induction of immunological responses.
arxiv
Advanced Science, EarlyView.AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang +8 more
wiley +1 more source
Greater Vulnerability of the Infecting Viral Strand of Replicative-Form Deoxyribonucleic Acid of Bacteriophage φX174 [PDF]
, 1970 B. Datta, Raju Poddar
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Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
Advanced Science, EarlyView.Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen +12 more
wiley +1 more source
Dynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques
Retrovirology, 2009 Background Extensive studies of primary infection are crucial to our understanding of the course of HIV disease. In SIV-infected macaques, a model closely mimicking HIV pathogenesis, we used a combination of three markers -- viral RNA, 2LTR circles and ...
Mannioui Abdelkrim +9 more
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