Results 251 to 260 of about 692,469 (310)

The neddylation of the RNA-dependent RNA polymerase 3D of Coxsackievirus B3 promotes viral replication. [PDF]

J Virol
Li S, Dong Y, Wang X, Feng D, Luan T, Wang Z, Lin L, Chen Y, Wang Y, Fei Y, Wang Y, Zhong Z, Zhao W.   +12 more
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS-STING. [PDF]

J Gen Virol
Chiu HP, Yeo YY, Lai TY, Hung CT, Kowdle S, Haas GD, Jiang S, Sun W, Lee B.   +8 more
europepmc   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Cryo-EM structure of influenza polymerase bound to the cRNA promoter provides insights into the mechanism of viral replication. [PDF]

Commun Biol
Wu Y, Li M, Li H, Bai Y, Sun T, Huang S, Liu Y, Liang H.   +7 more
europepmc   +1 more source

Phenotypic Diversity and Outcomes in Pediatric NMDA Receptor Encephalitis: A 15‐Year Retrospective Study from the Largest Children's Hospital in the United States

Advanced Science, EarlyView.
ABSTRACT Anti‐NMDAR encephalitis (NMDARE) is an autoantibody‐mediated disorder characterized by seizures, movement disorders, neurocognitive deficits, and psychosis, but the complete phenotypic heterogeneity, and outcomes are incompletely understood in children.
Alexander J. Sandweiss, Timothy Erickson, Yike Jiang, Varun Kannan, Jonathan M. Yarimi, Kristen S. Fisher, Nikita Shukla, Tim Lotze, Eyal Muscal, Kristy O. Murray   +9 more
wiley   +1 more source

N-glycosylation of the PEDV spike protein modulates viral replication and pathogenicity. [PDF]

Vet Res
Zhu H, Feng Z, Sun M, Zhang S, Yang Z, Bai J, Jiang P, Liu G, Liu X, Wang X.   +9 more
europepmc   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Synergetic contributions of Seneca Valley virus 3 C and 3D proteins to induction of ferroptosis for viral replication. [PDF]

Cell Mol Life Sci
Song J, Yang J, Ma R, Li Z, Su J, Xie S, Cheng P.   +6 more
europepmc   +1 more source

Replicon-based genome-wide CRISPR knockout screening for the identification of host factors involved in viral replication. [PDF]

Nat Commun
Cheng KW, Bhave M, Markhard AL, Peng D, Bhatt KD, Travisano KA, Medicielo JV, Anaya A, Lembirik S, Njoya L, Anantpadma M, Kuhn JH, Puschnik AS, Kistler AL.   +13 more
europepmc   +1 more source