Results 261 to 270 of about 84,140 (293)
A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals
EBioMedicine, 2015 © 2015 The Authors. Background: Quantifying latently infected cells is critical to evaluate the efficacy of therapeutic strategies aimed at reducing the size of the long-lived viral reservoir, but the low frequency of these cells makes this very ...
Rémi Fromentin +2 more
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Modeling HIV persistence, the latent reservoir, and viral blips [PDF]
Journal of Theoretical Biology, 2009 HIV-1 eradication from infected individuals has not been achieved with the prolonged use of highly active antiretroviral therapy (HAART). The cellular reservoir for HIV-1 in resting memory CD4(+) T cells remains a major obstacle to viral elimination. The reservoir does not decay significantly over long periods of time but is able to release replication-
Libin Rong, Alan S Perelson
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Annual Review of Virology, 2016
Bats are hosts of a range of viruses, including ebolaviruses, and many important human viral infections, such as measles and mumps, may have their ancestry traced back to bats. Here, I review viruses of all viral families detected in global bat populations.
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Bats are hosts of a range of viruses, including ebolaviruses, and many important human viral infections, such as measles and mumps, may have their ancestry traced back to bats. Here, I review viruses of all viral families detected in global bat populations.
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Quantitation of integrated proviral DNA in viral reservoirs
Current Opinion in HIV and AIDS, 2013Integrated HIV DNA can give rise to infectious virus, and therefore may be a surrogate of reservoir size. How this form reflects the amount of replication competent virus in vivo remains to be established. This review highlights the technical hurdles involved in measuring integrated HIV DNA, progress toward overcoming these hurdles by repetitive ...
Erin H, Graf, Una, O'Doherty
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Viral reservoirs and HIV-specific immunity
Current Opinion in Internal Medicine, 2006HIV-1 infection is complicated by the presence of latently infected CD4 T cells as well as several anatomical reservoirs that present a barrier to eradication by current antiretroviral therapy. The early establishment of these reservoirs also presents a challenge to the development of preventive vaccines.
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The Challenge of Viral Reservoirs in HIV-1 Infection
Annual Review of Medicine, 2002▪ Abstract A viral reservoir is a cell type or anatomical site in association with which a replication-competent form of the virus accumulates and persists with more stable kinetic properties than the main pool of actively replicating virus. This article reviews several cell types and anatomical sites proposed as potential reservoirs for HIV-1.
Joel N, Blankson +2 more
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Establishment and Replenishment of the Viral Reservoir in Perinatally HIV-1-infected Children Initiating Very Early Antiretroviral Therapy [PDF]
Clinical Infectious Diseases, 2015 Background. Combination antiretroviral therapy (cART) generally suppresses the replication of the human immunodeficiency virus type 1 (HIV-1) but does not cure the infection, because proviruses persist in stable latent reservoirs.
Marta Martínez-Bonet +2 more
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Attacking the HIV Reservoir from the Immune and Viral Perspective
Current HIV/AIDS Reports, 2012Upon HIV infection, a subset of latently infected cells carrying transcriptionally inactive integrated proviral DNA (the HIV-1 reservoir) is rapidly established. These cells are the main force behind HIV persistence under highly active antiretroviral therapy (HAART), which only impacts on actively replicating viruses and it is therefore unable to ...
Massanella, Marta +2 more
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AIDS, 2012
Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved.
Tae-Wook, Chun, Anthony S, Fauci
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Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved.
Tae-Wook, Chun, Anthony S, Fauci
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Non-invasive nuclear imaging for localization of viral reservoirs
Nature Methods, 2015Antibody-targeted positron emission tomography (immunoPET) can visualize sites of HIV replication that are difficult to access by traditional means such as tissue biopsies.
Ekaterina, Dadachova, Joan W, Berman
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