Results 261 to 270 of about 956,535 (302)

Quantitation of integrated proviral DNA in viral reservoirs

Current Opinion in HIV and AIDS, 2013
Integrated HIV DNA can give rise to infectious virus, and therefore may be a surrogate of reservoir size. How this form reflects the amount of replication competent virus in vivo remains to be established. This review highlights the technical hurdles involved in measuring integrated HIV DNA, progress toward overcoming these hurdles by repetitive ...
Erin H, Graf, Una, O'Doherty
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The Challenge of Viral Reservoirs in HIV-1 Infection

Annual Review of Medicine, 2002
▪ Abstract  A viral reservoir is a cell type or anatomical site in association with which a replication-competent form of the virus accumulates and persists with more stable kinetic properties than the main pool of actively replicating virus. This article reviews several cell types and anatomical sites proposed as potential reservoirs for HIV-1.
Joel N, Blankson, Deborah, Persaud, Robert F, Siliciano   +2 more
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Viral reservoirs and HIV-specific immunity

Current Opinion in Internal Medicine, 2006
HIV-1 infection is complicated by the presence of latently infected CD4 T cells as well as several anatomical reservoirs that present a barrier to eradication by current antiretroviral therapy. The early establishment of these reservoirs also presents a challenge to the development of preventive vaccines.
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Non-invasive nuclear imaging for localization of viral reservoirs

Nature Methods, 2015
Antibody-targeted positron emission tomography (immunoPET) can visualize sites of HIV replication that are difficult to access by traditional means such as tissue biopsies.
Ekaterina, Dadachova, Joan W, Berman
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Attacking the HIV Reservoir from the Immune and Viral Perspective

Current HIV/AIDS Reports, 2012
Upon HIV infection, a subset of latently infected cells carrying transcriptionally inactive integrated proviral DNA (the HIV-1 reservoir) is rapidly established. These cells are the main force behind HIV persistence under highly active antiretroviral therapy (HAART), which only impacts on actively replicating viruses and it is therefore unable to ...
Massanella, Marta, Martinez-Picado, Javier, Blanco, Julià   +2 more
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HIV reservoirs

AIDS, 2012
Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved.
Tae-Wook, Chun, Anthony S, Fauci
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HIV Persistence and Viral Reservoirs

2010
Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting memory CD4+ T-cells are an important cellular reservoir, and the central nervous system (CNS) an important anatomical reservoir for ...
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Viral pollution of some artificial reservoirs in Romania.

Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale B, Hygiene, 1984
Five reservoirs were investigated for the presence of enteroviruses by using simultaneously two methods for concentration (PE60 and yeast cells) and two techniques for isolation (inoculation into suckling mice and into cell cultures). The average rate of virus positive samples was lower in reservoir water than in the water of the adjoined rivers.
I, Nestor, L, Lazar, D, Sovrea, N, Ionescu   +3 more
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On HIV-1 latency and viral reservoirs

2015
HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and anatomical reservoirs. This thesis concerns several problematic issues of HIV-1 persistence, including ways to measure and monitor both the virus at low viral concentrations and the depletion of the reservoir.
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The role of viral reservoirs in HIV-1 infection

2013
Wainberg, Mark (Supervisor)
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