Results 251 to 260 of about 24,194,770 (306)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Deciphering pervasive domestication and active "dark matter" of proviruses in prokaryotes via precision border mapping. [PDF]

Sci Adv
Zhang M, Hao Y, Yi Y, Wang Y, Zhang T, Xiao X, Jian H.   +6 more
europepmc   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

PhoSARte: identification of SARS-CoV-2 phosphorylation sites using contrastive learning and protein language models. [PDF]

Brief Bioinform
Pham NT, Tran DT, Su Q, Jung Y, Bupi N, Kang D, Lee S, Manavalan B.   +7 more
europepmc   +1 more source

High prevalence of picobirnavirus genogroup I in calves without association with diarrhea in a dairy cattle herd, southeast Brazil. [PDF]

Vet Res Commun
Yoshitani GD, Silva DC, de Brito Vargas FA, de Oliveira MV, Fritzen JTT, Alfieri AF, Alfieri AA, Lorenzetti E.   +7 more
europepmc   +1 more source

Single-Cell Hepatitis B Sequencing Reveals Distinct Viral Infection Events Consistent With Superinfection. [PDF]

J Infect Dis
Mani M, Clipman SJ, Bailey JR, Sterling RK, Sulkowski MS, Anderson M, Olivo A, Belluccini G, Cloherty G, Ribeiro RM, Thio CL, Balagopal A.   +11 more
europepmc   +1 more source

Sequencing the wastewater virome: Current strategies and bioinformatic pitfalls. [PDF]

iScience
De Smedt M, Cuypers WL, Hudda NU, Delputte P.   +3 more
europepmc   +1 more source