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Viral structural proteins as targets for antivirals [PDF]

Current Opinion in Virology, 2020
Viral structural proteins are emerging as effective targets for new antivirals. In a viral lifecycle, the capsid must assemble, disassemble, and respond to host proteins, all at the right time and place. These reactions work within a narrow range of conditions, making them susceptible to small molecule interference.
Adam Zlotnick, Christopher John Schlicksup   +1 more
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Viral capsid proteins are segregated in structural fold space.

PLoS Computational Biology, 2013
Viral capsid proteins assemble into large, symmetrical architectures that are not found in complexes formed by their cellular counterparts. Given the prevalence of the signature jelly-roll topology in viral capsid proteins, we are interested in whether ...
Shanshan Cheng, Charles L Brooks
doaj   +5 more sources

Structural framework for DNA translocation via the viral portal protein [PDF]

The EMBO Journal, 2007
Tailed bacteriophages and herpesviruses load their capsids with DNA through a tunnel formed by the portal protein assembly. Here we describe the X-ray structure of the bacteriophage SPP1 portal protein in its isolated 13-subunit form and the pseudoatomic structure of a 12-subunit assembly.
Andrey A. Lebedev, M. Krause, Anabela Isidro, Alexei A. Vagin, Elena V. Orlova, Joanne Turner, E.J. Dodson, Paulo Tavares, Alfred A. Antson   +8 more
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Modification of viral structural proteins of herpesvirus sylvilagus by glycosylation and phosphorylation [PDF]

Journal of Virology, 1984
The structural proteins of herpesvirus sylvilagus, a lymphotropic gamma herpesvirus, were analyzed by sodium dodecyl sulfate and two-dimensional polyacrylamide gel electrophoreses. Modification of the proteins by glycosylation and phosphorylation was shown by the incorporation of [14C]glucosamine or 32Pi into material which comigrated with [35S ...
H. Rouhandeh, Randall J. Cohrs
openalex   +4 more sources

Insights into the Structure, Replication, and Pathogenesis of the Severe Acute Respiratory Syndrome Coronavirus 2

Re:GEN Open, 2022
Background: The recent coronavirus disease-19 (COVID-19) emergence worldwide associated with pneumonia-like symptoms poses a great threat to human health.
Sania Aamir, Iqra Mir, Muhammad Shahid, Iram Amin, Samia Afzal, Shazia Rafique, Rashid Bhatti, Amjad Nawaz, Fatima Butt, Rakhtasha Munir, Muhammad Idrees, Kausar Malik   +11 more
doaj   +1 more source

Aquareovirus NS80 Initiates Efficient Viral Replication by Retaining Core Proteins within Replication-Associated Viral Inclusion Bodies. [PDF]

PLoS ONE, 2015
Viral inclusion bodies (VIBs) are specific intracellular compartments for reoviruses replication and assembly. Aquareovirus nonstructural protein NS80 has been identified to be the major constituent for forming globular VIBs in our previous study.
Liming Yan, Jie Zhang, Hong Guo, Shicui Yan, Qingxiu Chen, Fuxian Zhang, Qin Fang   +6 more
doaj   +1 more source

Molecular basis of COVID-19 pathogenesis and in silico studies of potential pharmacological treatment

Revista de la Facultad de Medicina Humana, 2021
COVID-19 is a disease caused by SARS-CoV-2, a virus that represents a serious threat to global health. The objective of the article is to deepen into the structure of the structural and non-structural proteins of SARS-CoV-2 and their role during the ...
Eduardo Rubén Lam Cabanillas, Anthony Omar León Risco, Kevyn Bryce León Risco, Gaby Lisbeth Llamo Hoyos, Rosa María López Zavaleta, Estefanía del Rocío Luzuriaga Tirado, Alex Michael Mendoza Blas, Juan Jorge Huamán Saavedra   +7 more
doaj   +1 more source

VPDB: Viral Protein Structural Database [PDF]

Bioinformation, 2011
Viral Protein Database is an interactive database for three dimensional viral proteins. Our aim is to provide a comprehensive resource to the community of structural virology, with an emphasis on the description of derived data from structural biology.
Afzal Hussain, Ankush Jadhav, Om Prakash Sharma, Muthuvel Suresh Kumar   +3 more
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Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins

Membranes, 2022
Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins.
Qingxin Li, Congbao Kang
doaj   +1 more source

Protein–Protein Interfaces in Viral Capsids Are Structurally Unique [PDF]

Journal of Molecular Biology, 2015
Viral capsids exhibit elaborate and symmetrical architectures of defined sizes and remarkable mechanical properties not seen with cellular macromolecular complexes. Given the uniqueness of the higher-order organization of viral capsid proteins in the virosphere, we explored the question of whether the patterns of protein-protein interactions within ...
Charles L. Brooks, Shanshan Cheng
openaire   +2 more sources