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Viral structural proteins as targets for antivirals. [PDF]
Curr Opin Virol, 2020 Viral structural proteins are emerging as effective targets for new antivirals. In a viral lifecycle, the capsid must assemble, disassemble, and respond to host proteins, all at the right time and place. These reactions work within a narrow range of conditions, making them susceptible to small molecule interference.
Schlicksup CJ, Zlotnick A.
europepmc +5 more sources
Roles of African swine fever virus structural proteins in viral infection [PDF]
Journal of Veterinary Research, 2017 African swine fever virus (ASFV) is a large, double-stranded DNA virus and the sole member of the Asfarviridae family. ASFV infects domestic pigs, wild boars, warthogs, and bush pigs, as well as soft ticks (Ornithodoros erraticus), which likely act as a ...
Jia Ning +4 more
doaj +4 more sources
Non-structural proteins of bovine viral diarrhea virus
Virus Genes, 2022 Bovine viral diarrhea virus (BVDV) belongs to the family Flaviviridae genus pestivirus. The viral genome is a single-stranded, positive-sense RNA that encodes four structural proteins (i.e., C, Erns, E1, and E2) and eight non-structural proteins (NSPs ...
S. Chi +5 more
semanticscholar +3 more sources
Illuminating structural proteins in viral “dark matter” with metaproteomics [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Marine viruses are abundant and have substantial ecosystem impacts, yet their study is hampered by the dominance of unannotated viral genes.
Jennifer R. Brum +8 more
semanticscholar +5 more sources
Sindbis viral structural protein cytotoxicity on human neuroblastoma cells [PDF]
Pediatric Surgery International, 2020 Oncolytic viral therapy for neuroblastoma (NB) cells with Sindbis virus (SINV) is a promising strategy for treating high-risk NB. Here, we evaluated the possibility of using SINV structural proteins as therapeutic agents for NB since UV-inactivated SINV ...
E. Saito +9 more
semanticscholar +3 more sources
Viral capsid proteins are segregated in structural fold space.
PLoS Computational Biology, 2013 Viral capsid proteins assemble into large, symmetrical architectures that are not found in complexes formed by their cellular counterparts. Given the prevalence of the signature jelly-roll topology in viral capsid proteins, we are interested in whether ...
Shanshan Cheng, Charles L Brooks
doaj +4 more sources
Viruses, 2023 The porcine reproductive and respiratory syndrome virus (PRRSV) causes economic losses in the swine industry worldwide. However, current vaccines cannot provide effective protection against PRRSV, and PRRSV-specific treatments for infected herds are ...
Zhenbang Zhu +4 more
doaj +3 more sources
Roles of the Non-Structural Proteins of Influenza A Virus
Pathogens, 2020 Influenza A virus (IAV) is a segmented, negative single-stranded RNA virus that causes seasonal epidemics and has a potential for pandemics. Several viral proteins are not packed in the IAV viral particle and only expressed in the infected host cells ...
Wenzhuo Hao, Lingyan Wang, Shitao Li
doaj +2 more sources
Wart-associated antigens. II. Human immunity to viral structural proteins.
Journal of Investigative Dermatology, 1973 The nature and specificity of antibody formation to human papilloma virus was studied with sera from patients with warts. Sera were fractionated by molecular sieve chromatography and the immunoglobulin fractions were tested against purified virions and viral components. Sera from seven of 33 patients contained precipitating antibodies of the IgG class,
F. Pass, J. Maizel
semanticscholar +3 more sources
Structural and Functional Insights into Viral and Fungal Proteins Involved in Chronic Inflammation and Their Biologic Treatments [PDF]
PharmaceuticsChronic inflammation constitutes a significant characteristic of sustained infections caused by viral and fungal pathogens, with a strong correlation to the development of cancer, autoimmune disorders, and tissue fibrosis.
Mohamed Halawa +2 more
doaj +2 more sources